Expression of activin A is increased in cirrhotic and fibrotic rat livers

Background & Aims: Activin A, a member of the transforming growth factor (TGF)-β superfamily, recently has been reported to suppress DNA synthesis and to induce apoptosis of hepatocytes. These biological functions are similar to those of TGF-β1, which is overexpressed in liver cirrhosis. The aim...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1998-03, Vol.114 (3), p.550-558
Hauptverfasser:	Sugiyama, Motoya, Ichida, Takafumi, Sato, Tomomi, Ishikawa, Toru, Matsuda, Yasunobu, Asakura, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Activins Adipocytes - metabolism Animals Biological and medical sciences Cells, Cultured Collagen - genetics DNA - biosynthesis Fibroblasts - metabolism Gastroenterology. Liver. Pancreas. Abdomen Inhibins - biosynthesis Inhibins - genetics Liver - metabolism Liver Cirrhosis, Experimental - metabolism Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Other diseases. Semiology Rats Rats, Sprague-Dawley RNA, Messenger - analysis Transforming Growth Factor beta - pharmacology
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