Cloning and expression of a chimeric antibody directed against the human transferrin receptor

The cloning, construction and expression of chimeric Ig genes, encoding a mAb directed against the human transferrin receptor, is described. From a mouse hybridoma cell line, secreting an antitransferrin receptor antibody, mRNA was prepared and converted into cDNA using Ig-specific oligonucleotides....

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Veröffentlicht in:	The Journal of immunology (1950) 1990-04, Vol.144 (8), p.3211-3217
Hauptverfasser:	Hoogenboom, HR, Raus, JC, Volckaert, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Monoclonal - genetics Antibodies, Monoclonal - immunology Antibody Specificity Base Sequence Biological and medical sciences Biotechnology Blotting, Western Cloning, Molecular DNA - genetics Fundamental and applied biological sciences. Psychology Genes, Immunoglobulin Genetic engineering Genetic technics Humans immunoglobulin G Methods. Procedures. Technologies Mice Molecular cloning Molecular Sequence Data Molecular Weight Precipitin Tests Receptors, Transferrin - immunology Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Transfection transferrin receptors
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