Brainstem auditory evoked potentials in Wilson's disease
Twelve patients with Wilson's disease, aged 11–25 years, underwent brainstem auditory evoked potential (BAEP) study. The results were correlated to clinical, neuroradiological and laboratory data. Ten had prominent to severe neurological manifestations, suggestive of involvement of one or sever...
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| Veröffentlicht in: | Journal of the neurological sciences 1990-02, Vol.95 (2), p.163-169 |
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| container_title | Journal of the neurological sciences |
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| creator | Butinar, Dušan Trontelj, Jože V. Khuraibet, Adnan J. Khan, Riyad A. Hussein, Jassim M. Shakir, Ra'ad A. |
| description | Twelve patients with Wilson's disease, aged 11–25 years, underwent brainstem auditory evoked potential (BAEP) study. The results were correlated to clinical, neuroradiological and laboratory data. Ten had prominent to severe neurological manifestations, suggestive of involvement of one or several CNS structures, and 2 were neurologically free. All had evidence of abnormal copper metabolism, and 8 had CT scan evidence of brain atrophy, or hypodense areas in basal ganglia, or both. The 2 patients without neurological manifestations as well as one with neurological signs had normal BAEP. One patient with neurological signs had increased N1 latency due to cochlear hearing loss, but normal interpeak intervals, while 8 of 10 patients with prominent neurological symptoms and signs had abnormal BAEPs (prolongation of NIII-NV interpeak interval). The value of NIII-NV interpeak interval correlated with the number of different neurological signs (neurological score) attributable to involvement of different CNS structures (
r = 0.64 at
P = 0.001). Abnormal BAEPs do not seem to be an early finding in Wilson's disease. |
| doi_str_mv | 10.1016/0022-510X(90)90239-J |
| format | Article |
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r = 0.64 at
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r = 0.64 at
P = 0.001). Abnormal BAEPs do not seem to be an early finding in Wilson's disease.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Brain Stem - physiopathology</subject><subject>Brainstem auditory evoked potentials</subject><subject>Child</subject><subject>CT findings</subject><subject>Electrodiagnosis. Electric activity recording</subject><subject>Evoked Potentials, Auditory</subject><subject>Female</subject><subject>Hepatolenticular Degeneration - physiopathology</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurological manifestations</subject><subject>Reaction Time</subject><subject>Silent CNS lesions</subject><subject>Wilson's disease</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKw0AUhgdRar28gUIW4mURnUuSmWwELd5KwY2iu2EuJzCaZupMUujbm9rQpasD5__-w-FD6ITga4JJcYMxpWlO8Odlia9KTFmZTnfQmAgu0lwItovGW2QfHcT4hTEuhChHaEQZzXjBx0jcB-Wa2MI8UZ11rQ-rBJb-G2yy8C00rVN1TFyTfLg6-uYiJtZFUBGO0F7VR3A8zEP0_vjwNnlOZ69PL5O7WWoYJm3KKq4xtUxpAtZqA5znvH9Cl0WmBLOMAu0XuRWaEEMqbjSjnFqtBGYFWHaIzjd3F8H_dBBbOXfRQF2rBnwXJS85EZjzHsw2oAk-xgCVXAQ3V2ElCZZrYXJtQ65tyBLLP2Fy2tdOh_udnoPdlgZDfX425CoaVVdBNcbFLZYVlPI867HbDQa9i6WDIKNx0BiwLoBppfXu_z9-ASEyhvY</recordid><startdate>199002</startdate><enddate>199002</enddate><creator>Butinar, Dušan</creator><creator>Trontelj, Jože V.</creator><creator>Khuraibet, Adnan J.</creator><creator>Khan, Riyad A.</creator><creator>Hussein, Jassim M.</creator><creator>Shakir, Ra'ad A.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199002</creationdate><title>Brainstem auditory evoked potentials in Wilson's disease</title><author>Butinar, Dušan ; Trontelj, Jože V. ; Khuraibet, Adnan J. ; Khan, Riyad A. ; Hussein, Jassim M. ; Shakir, Ra'ad A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-3f7b02d3ab1eddbce7757688b964a83d32e25765d8b11c1f7cb3272dba8036ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Brain Stem - physiopathology</topic><topic>Brainstem auditory evoked potentials</topic><topic>Child</topic><topic>CT findings</topic><topic>Electrodiagnosis. Electric activity recording</topic><topic>Evoked Potentials, Auditory</topic><topic>Female</topic><topic>Hepatolenticular Degeneration - physiopathology</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurological manifestations</topic><topic>Reaction Time</topic><topic>Silent CNS lesions</topic><topic>Wilson's disease</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Butinar, Dušan</creatorcontrib><creatorcontrib>Trontelj, Jože V.</creatorcontrib><creatorcontrib>Khuraibet, Adnan J.</creatorcontrib><creatorcontrib>Khan, Riyad A.</creatorcontrib><creatorcontrib>Hussein, Jassim M.</creatorcontrib><creatorcontrib>Shakir, Ra'ad A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Butinar, Dušan</au><au>Trontelj, Jože V.</au><au>Khuraibet, Adnan J.</au><au>Khan, Riyad A.</au><au>Hussein, Jassim M.</au><au>Shakir, Ra'ad A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brainstem auditory evoked potentials in Wilson's disease</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1990-02</date><risdate>1990</risdate><volume>95</volume><issue>2</issue><spage>163</spage><epage>169</epage><pages>163-169</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>Twelve patients with Wilson's disease, aged 11–25 years, underwent brainstem auditory evoked potential (BAEP) study. The results were correlated to clinical, neuroradiological and laboratory data. Ten had prominent to severe neurological manifestations, suggestive of involvement of one or several CNS structures, and 2 were neurologically free. All had evidence of abnormal copper metabolism, and 8 had CT scan evidence of brain atrophy, or hypodense areas in basal ganglia, or both. The 2 patients without neurological manifestations as well as one with neurological signs had normal BAEP. One patient with neurological signs had increased N1 latency due to cochlear hearing loss, but normal interpeak intervals, while 8 of 10 patients with prominent neurological symptoms and signs had abnormal BAEPs (prolongation of NIII-NV interpeak interval). The value of NIII-NV interpeak interval correlated with the number of different neurological signs (neurological score) attributable to involvement of different CNS structures (
r = 0.64 at
P = 0.001). Abnormal BAEPs do not seem to be an early finding in Wilson's disease.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>2324767</pmid><doi>10.1016/0022-510X(90)90239-J</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Biological and medical sciences Brain Stem - physiopathology Brainstem auditory evoked potentials Child CT findings Electrodiagnosis. Electric activity recording Evoked Potentials, Auditory Female Hepatolenticular Degeneration - physiopathology Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Neurological manifestations Reaction Time Silent CNS lesions Wilson's disease |
| title | Brainstem auditory evoked potentials in Wilson's disease |
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