Hormone-induced changes in nuclear receptor stoichiometry in HL60 cells correlate with induction of monocyte or neutrophil differentiation

HL60 cells differentiate to monocytes or neutrophils in response to 1 alpha,25(OH)2-vitamin D3 (D3) and retinoids respectively. D3 and retinoid actions converge since their receptors (VDR, RAR) heterodimerise with a common partner, RXR, which also interacts with thyroid hormone (T3) receptors (T3R)....

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Veröffentlicht in:	Journal of endocrinology 1998-01, Vol.156 (1), p.135-148
Hauptverfasser:	McTernan, PG, Sheppard, MC, Williams, GR
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blotting, Western Cell Differentiation Cell differentiation, maturation, development, hematopoiesis Cell physiology Cholecalciferol - pharmacology Dimerization Fundamental and applied biological sciences. Psychology HL-60 Cells - cytology HL-60 Cells - drug effects HL-60 Cells - metabolism Humans Leukocytes, Mononuclear - cytology Molecular and cellular biology Neutrophils - cytology Receptors, Calcitriol - metabolism Receptors, Cytoplasmic and Nuclear - drug effects Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Retinoic Acid - metabolism Retinoids - pharmacology
Online-Zugang:	Volltext
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