Effects of lowering [Na +] o and [K +] o and of ouabain on quisqualate-induced ionic changes in area CA1 of rat hippocampal slices
Changes in extracellular ([Na +] o) and calcium ([Ca 2+] o) concentration evoked by quisqualate (Quis), applied iontophoretically, were measured in rat hippocampal slices. Following an initial decrease in [Ca 2+] o, Quis causes a post-application overshoot, which may reflect Ca 2+ extrusion from cel...
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| Veröffentlicht in: | Neuroscience letters 1990-03, Vol.110 (1), p.60-65 |
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| creator | Stabel, Jasmine Arens, Jürgen Lambert, John D.C. Heinemann, Uwe |
| description | Changes in extracellular ([Na
+]
o) and calcium ([Ca
2+]
o) concentration evoked by quisqualate (Quis), applied iontophoretically, were measured in rat hippocampal slices. Following an initial decrease in [Ca
2+]
o, Quis causes a post-application overshoot, which may reflect Ca
2+ extrusion from cells by the
Na
+
Ca
2+
exchanger. To test this hypothesis, the effects of directly and indirectly reduced transmembrane Na
+ gradients on these Quis-induced Ca
2+ overshoots were investigated. In all cases the post-application overshoots were reduced. This suggests that the
Na
+
Ca
2+
exchanger is involved in the production of these Quis-induced Ca
2+ overshoots which may have important implications for understanding how various types of glutamate receptors differ in their capability to trigger Ca
2+-activated processes. |
| doi_str_mv | 10.1016/0304-3940(90)90787-A |
| format | Article |
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+]
o) and calcium ([Ca
2+]
o) concentration evoked by quisqualate (Quis), applied iontophoretically, were measured in rat hippocampal slices. Following an initial decrease in [Ca
2+]
o, Quis causes a post-application overshoot, which may reflect Ca
2+ extrusion from cells by the
Na
+
Ca
2+
exchanger. To test this hypothesis, the effects of directly and indirectly reduced transmembrane Na
+ gradients on these Quis-induced Ca
2+ overshoots were investigated. In all cases the post-application overshoots were reduced. This suggests that the
Na
+
Ca
2+
exchanger is involved in the production of these Quis-induced Ca
2+ overshoots which may have important implications for understanding how various types of glutamate receptors differ in their capability to trigger Ca
2+-activated processes.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(90)90787-A</identifier><identifier>PMID: 2183088</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>[formula omitted] exchanger ; Animals ; Extracellular Ca 2 ; Extracellular Na ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - physiology ; In Vitro Techniques ; Membrane Potentials - drug effects ; Ouabain ; Ouabain - pharmacology ; Oxadiazoles - pharmacology ; Potassium - physiology ; Quisqualate ; Quisqualic Acid ; Rats ; Rats, Inbred Strains ; Sodium - physiology ; Transmembrane Na + gradient</subject><ispartof>Neuroscience letters, 1990-03, Vol.110 (1), p.60-65</ispartof><rights>1990</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c272t-40e54d9f6d8976e110e15ad9b5e9f01c6fc6d7af5a60a797c7915e6a75bcf9e83</citedby><cites>FETCH-LOGICAL-c272t-40e54d9f6d8976e110e15ad9b5e9f01c6fc6d7af5a60a797c7915e6a75bcf9e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0304-3940(90)90787-A$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2183088$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stabel, Jasmine</creatorcontrib><creatorcontrib>Arens, Jürgen</creatorcontrib><creatorcontrib>Lambert, John D.C.</creatorcontrib><creatorcontrib>Heinemann, Uwe</creatorcontrib><title>Effects of lowering [Na +] o and [K +] o and of ouabain on quisqualate-induced ionic changes in area CA1 of rat hippocampal slices</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Changes in extracellular ([Na
+]
o) and calcium ([Ca
2+]
o) concentration evoked by quisqualate (Quis), applied iontophoretically, were measured in rat hippocampal slices. Following an initial decrease in [Ca
2+]
o, Quis causes a post-application overshoot, which may reflect Ca
2+ extrusion from cells by the
Na
+
Ca
2+
exchanger. To test this hypothesis, the effects of directly and indirectly reduced transmembrane Na
+ gradients on these Quis-induced Ca
2+ overshoots were investigated. In all cases the post-application overshoots were reduced. This suggests that the
Na
+
Ca
2+
exchanger is involved in the production of these Quis-induced Ca
2+ overshoots which may have important implications for understanding how various types of glutamate receptors differ in their capability to trigger Ca
2+-activated processes.</description><subject>[formula omitted] exchanger</subject><subject>Animals</subject><subject>Extracellular Ca 2</subject><subject>Extracellular Na</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - physiology</subject><subject>In Vitro Techniques</subject><subject>Membrane Potentials - drug effects</subject><subject>Ouabain</subject><subject>Ouabain - pharmacology</subject><subject>Oxadiazoles - pharmacology</subject><subject>Potassium - physiology</subject><subject>Quisqualate</subject><subject>Quisqualic Acid</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Sodium - physiology</subject><subject>Transmembrane Na + gradient</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV1LHDEUhoNU7Gr7DyzkSpQybTJfmdwIy2Jbqdib9kpKOJucaGQ2mU1mKr31lzfDLnpXCCRwnvcczhNCTjn7xBlvP7OK1UUla3Yu2YVkohPF8oAseCfKQkhRviGLF-QtOU7pkTHW8KY-Ikcl7yrWdQvyfGUt6jHRYGkfnjA6f0_vboF-_E0DBW_o3ffXd4bCBGtwngZPt5NL2wl6GLFw3kwaDXXBO031A_h7TDRzEBHoasnnbISRPrhhCBo2A_Q09U5jekcOLfQJ3-_vE_Lry9XP1bfi5sfX69XyptClKMeiZtjURtrWdFK0yDlD3oCR6walZVy3VrdGgG2gZZD310LyBlsQzVpbiV11Qs52fYcYthOmUW1c0tj34DFMSeUMF3UlM1jvQB1DShGtGqLbQPyrOFOzejV7VbNXJeeT1atljn3Y95_WGzQvob3rXL_c1TEv-cdhVEk79Nmai_kLlAnu_wP-AU6Hkmk</recordid><startdate>19900302</startdate><enddate>19900302</enddate><creator>Stabel, Jasmine</creator><creator>Arens, Jürgen</creator><creator>Lambert, John D.C.</creator><creator>Heinemann, Uwe</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900302</creationdate><title>Effects of lowering [Na +] o and [K +] o and of ouabain on quisqualate-induced ionic changes in area CA1 of rat hippocampal slices</title><author>Stabel, Jasmine ; Arens, Jürgen ; Lambert, John D.C. ; Heinemann, Uwe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-40e54d9f6d8976e110e15ad9b5e9f01c6fc6d7af5a60a797c7915e6a75bcf9e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>[formula omitted] exchanger</topic><topic>Animals</topic><topic>Extracellular Ca 2</topic><topic>Extracellular Na</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - physiology</topic><topic>In Vitro Techniques</topic><topic>Membrane Potentials - drug effects</topic><topic>Ouabain</topic><topic>Ouabain - pharmacology</topic><topic>Oxadiazoles - pharmacology</topic><topic>Potassium - physiology</topic><topic>Quisqualate</topic><topic>Quisqualic Acid</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Sodium - physiology</topic><topic>Transmembrane Na + gradient</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stabel, Jasmine</creatorcontrib><creatorcontrib>Arens, Jürgen</creatorcontrib><creatorcontrib>Lambert, John D.C.</creatorcontrib><creatorcontrib>Heinemann, Uwe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stabel, Jasmine</au><au>Arens, Jürgen</au><au>Lambert, John D.C.</au><au>Heinemann, Uwe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of lowering [Na +] o and [K +] o and of ouabain on quisqualate-induced ionic changes in area CA1 of rat hippocampal slices</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1990-03-02</date><risdate>1990</risdate><volume>110</volume><issue>1</issue><spage>60</spage><epage>65</epage><pages>60-65</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><abstract>Changes in extracellular ([Na
+]
o) and calcium ([Ca
2+]
o) concentration evoked by quisqualate (Quis), applied iontophoretically, were measured in rat hippocampal slices. Following an initial decrease in [Ca
2+]
o, Quis causes a post-application overshoot, which may reflect Ca
2+ extrusion from cells by the
Na
+
Ca
2+
exchanger. To test this hypothesis, the effects of directly and indirectly reduced transmembrane Na
+ gradients on these Quis-induced Ca
2+ overshoots were investigated. In all cases the post-application overshoots were reduced. This suggests that the
Na
+
Ca
2+
exchanger is involved in the production of these Quis-induced Ca
2+ overshoots which may have important implications for understanding how various types of glutamate receptors differ in their capability to trigger Ca
2+-activated processes.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>2183088</pmid><doi>10.1016/0304-3940(90)90787-A</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1990-03, Vol.110 (1), p.60-65 |
| issn | 0304-3940 1872-7972 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79717439 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | [formula omitted] exchanger Animals Extracellular Ca 2 Extracellular Na Hippocampus Hippocampus - drug effects Hippocampus - physiology In Vitro Techniques Membrane Potentials - drug effects Ouabain Ouabain - pharmacology Oxadiazoles - pharmacology Potassium - physiology Quisqualate Quisqualic Acid Rats Rats, Inbred Strains Sodium - physiology Transmembrane Na + gradient |
| title | Effects of lowering [Na +] o and [K +] o and of ouabain on quisqualate-induced ionic changes in area CA1 of rat hippocampal slices |
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