Mechanism-based inactivation of human cytochrome P450 3A4 by grapefruit juice and red wine

Grapefruit juice is well documented to cause clinically significant increases in the plasma concentrations of many therapeutic agents. These interactions are believed to be mediated via inhibition of intestinal cytochrome P-450 3A4 (CYP3A4) by flavonoids and/or other chemicals in grapefruit juice, a...

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Veröffentlicht in:	Life sciences (1973) 1998, Vol.62 (10), p.PL135-PL142
Hauptverfasser:	Chan, William K., Nguyen, Loc T., Miller, Vaughn P., harris, Robert Z.
Format:	Artikel
Sprache:	eng
Schlagworte:	Beverages Citrus cytochrome P-450 3A4 Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors - pharmacology grapefruit juice Humans Kinetics mechanism of inhibition Mixed Function Oxygenases - antagonists & inhibitors NADP - pharmacology red wine Wine
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