Acute alterations of cyclo(His-Pro) levels after oral ingestion of glucose
We analyzed the response of plasma cyclo(His-Pro) (CHP) (N = 14), insulin (N = 8), and glucose (N = 8) to oral ingestion of 75 grams of glucose in normal volunteers. Mean Fasting CHP levels prior to glucose were 614 ± 112 pg/ml (±SE). After glucose ingestion there occurred an acute rise of plasma CH...
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| Veröffentlicht in: | Neuropeptides (Edinburgh) 1990, Vol.15 (1), p.55-59 |
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| creator | Hilton, C.W. Prasad, C. Wilber, J.F. |
| description | We analyzed the response of plasma cyclo(His-Pro) (CHP) (N = 14), insulin (N = 8), and glucose (N = 8) to oral ingestion of 75 grams of glucose in normal volunteers. Mean Fasting CHP levels prior to glucose were 614 ± 112 pg/ml (±SE). After glucose ingestion there occurred an acute rise of plasma CHP within 15 minutes (
12
14
) followed by a fall in plasma concentrations to below baseline values (11 of 14). The mean of highest levels within the first 15 minutes after glucose ingestion was 1035 ± 300 pg/ml (±SE), significantly above baseline (p = 0.002). The mean of lowest values below baseline was 490 ± 94 pg/ml (±SE), p < 0.001. We conclude that levels of CHP are acutely and reversibly altered by the ingestion of glucose. The possible significance of these perturbations in CHP concentrations is discussed. |
| doi_str_mv | 10.1016/0143-4179(90)90161-Q |
| format | Article |
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12
14
) followed by a fall in plasma concentrations to below baseline values (11 of 14). The mean of highest levels within the first 15 minutes after glucose ingestion was 1035 ± 300 pg/ml (±SE), significantly above baseline (p = 0.002). The mean of lowest values below baseline was 490 ± 94 pg/ml (±SE), p < 0.001. We conclude that levels of CHP are acutely and reversibly altered by the ingestion of glucose. The possible significance of these perturbations in CHP concentrations is discussed.</description><identifier>ISSN: 0143-4179</identifier><identifier>EISSN: 1532-2785</identifier><identifier>DOI: 10.1016/0143-4179(90)90161-Q</identifier><identifier>PMID: 2183084</identifier><identifier>CODEN: NRPPDD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Apud cells. Peptide and protein hormones. Growth factors ; Biological and medical sciences ; Blood Glucose - metabolism ; Diet ; Fasting ; Female ; Fundamental and applied biological sciences. Psychology ; Glucose - metabolism ; Humans ; Insulin - blood ; Male ; Middle Aged ; Peptides, Cyclic - blood ; Peptides, Cyclic - metabolism ; Piperazines - blood ; Piperazines - metabolism ; Vertebrates: endocrinology</subject><ispartof>Neuropeptides (Edinburgh), 1990, Vol.15 (1), p.55-59</ispartof><rights>1990</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-f2a377f4a9ee447b821f8dfded8c40ff5c8ce3b698b59647b61acdd38b4b4d0f3</citedby><cites>FETCH-LOGICAL-c386t-f2a377f4a9ee447b821f8dfded8c40ff5c8ce3b698b59647b61acdd38b4b4d0f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0143-4179(90)90161-Q$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,4023,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6725760$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2183084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hilton, C.W.</creatorcontrib><creatorcontrib>Prasad, C.</creatorcontrib><creatorcontrib>Wilber, J.F.</creatorcontrib><title>Acute alterations of cyclo(His-Pro) levels after oral ingestion of glucose</title><title>Neuropeptides (Edinburgh)</title><addtitle>Neuropeptides</addtitle><description>We analyzed the response of plasma cyclo(His-Pro) (CHP) (N = 14), insulin (N = 8), and glucose (N = 8) to oral ingestion of 75 grams of glucose in normal volunteers. Mean Fasting CHP levels prior to glucose were 614 ± 112 pg/ml (±SE). After glucose ingestion there occurred an acute rise of plasma CHP within 15 minutes (
12
14
) followed by a fall in plasma concentrations to below baseline values (11 of 14). The mean of highest levels within the first 15 minutes after glucose ingestion was 1035 ± 300 pg/ml (±SE), significantly above baseline (p = 0.002). The mean of lowest values below baseline was 490 ± 94 pg/ml (±SE), p < 0.001. We conclude that levels of CHP are acutely and reversibly altered by the ingestion of glucose. The possible significance of these perturbations in CHP concentrations is discussed.</description><subject>Apud cells. Peptide and protein hormones. Growth factors</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Diet</subject><subject>Fasting</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Peptides, Cyclic - blood</subject><subject>Peptides, Cyclic - metabolism</subject><subject>Piperazines - blood</subject><subject>Piperazines - metabolism</subject><subject>Vertebrates: endocrinology</subject><issn>0143-4179</issn><issn>1532-2785</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMoun78A4UeRPRQTZq0SS_CIn4iqKDnkCYTiWQbTVrBf2_qLnv0NDDvM8PLg9AhwecEk-YCE0ZLRnh72uKzNm9I-bKBZqSmVVlxUW-i2RrZQbspfWCMWSXENtquiKBYsBl6mOtxgEL5AaIaXOhTEWyhf7QPp3culc8xnBUevsGnQtkMFSEqX7j-HdKET_S7H3VIsI-2rPIJDlZzD73dXL9e3ZWPT7f3V_PHUlPRDKWtFOXcMtUCMMY7URErjDVghGbY2loLDbRrWtHVbZOBhihtDBUd65jBlu6hk-Xfzxi-xlxDLlzS4L3qIYxJ8paTBhOaQbYEdQwpRbDyM7qFij-SYDkplJMfOfmRLZZ_CuVLPjta_R-7BZj10cpZzo9XuUpaeRtVr11aYw2vat7gjF0usawOvh1EmbSDXoNxEfQgTXD_9_gFBFuNbw</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Hilton, C.W.</creator><creator>Prasad, C.</creator><creator>Wilber, J.F.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>Acute alterations of cyclo(His-Pro) levels after oral ingestion of glucose</title><author>Hilton, C.W. ; Prasad, C. ; Wilber, J.F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-f2a377f4a9ee447b821f8dfded8c40ff5c8ce3b698b59647b61acdd38b4b4d0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Apud cells. Peptide and protein hormones. Growth factors</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Diet</topic><topic>Fasting</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Peptides, Cyclic - blood</topic><topic>Peptides, Cyclic - metabolism</topic><topic>Piperazines - blood</topic><topic>Piperazines - metabolism</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hilton, C.W.</creatorcontrib><creatorcontrib>Prasad, C.</creatorcontrib><creatorcontrib>Wilber, J.F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropeptides (Edinburgh)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hilton, C.W.</au><au>Prasad, C.</au><au>Wilber, J.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute alterations of cyclo(His-Pro) levels after oral ingestion of glucose</atitle><jtitle>Neuropeptides (Edinburgh)</jtitle><addtitle>Neuropeptides</addtitle><date>1990</date><risdate>1990</risdate><volume>15</volume><issue>1</issue><spage>55</spage><epage>59</epage><pages>55-59</pages><issn>0143-4179</issn><eissn>1532-2785</eissn><coden>NRPPDD</coden><abstract>We analyzed the response of plasma cyclo(His-Pro) (CHP) (N = 14), insulin (N = 8), and glucose (N = 8) to oral ingestion of 75 grams of glucose in normal volunteers. Mean Fasting CHP levels prior to glucose were 614 ± 112 pg/ml (±SE). After glucose ingestion there occurred an acute rise of plasma CHP within 15 minutes (
12
14
) followed by a fall in plasma concentrations to below baseline values (11 of 14). The mean of highest levels within the first 15 minutes after glucose ingestion was 1035 ± 300 pg/ml (±SE), significantly above baseline (p = 0.002). The mean of lowest values below baseline was 490 ± 94 pg/ml (±SE), p < 0.001. We conclude that levels of CHP are acutely and reversibly altered by the ingestion of glucose. The possible significance of these perturbations in CHP concentrations is discussed.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>2183084</pmid><doi>10.1016/0143-4179(90)90161-Q</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Apud cells. Peptide and protein hormones. Growth factors Biological and medical sciences Blood Glucose - metabolism Diet Fasting Female Fundamental and applied biological sciences. Psychology Glucose - metabolism Humans Insulin - blood Male Middle Aged Peptides, Cyclic - blood Peptides, Cyclic - metabolism Piperazines - blood Piperazines - metabolism Vertebrates: endocrinology |
| title | Acute alterations of cyclo(His-Pro) levels after oral ingestion of glucose |
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