Leptin and body composition of Nigerians, Jamaicans, and US blacks
The role of leptin in humans remains controversial. Leptin concentrations are highly correlated with body fat stores. We tested whether or not this relation was consistent across the range of body composition encompassing the lean as well as the obese. Individuals participating in community-based co...
Gespeichert in:
| Veröffentlicht in: | The American journal of clinical nutrition 1998-03, Vol.67 (3), p.391-396 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 396 |
|---|---|
| container_issue | 3 |
| container_start_page | 391 |
| container_title | The American journal of clinical nutrition |
| container_volume | 67 |
| creator | Luke, AH Rotimi, CN Cooper, RS Long, AE Forrester, TE Wilks, R Bennett, FI Ogunbiyi, O Compton, JA Bowsher, RR |
| description | The role of leptin in humans remains controversial. Leptin concentrations are highly correlated with body fat stores. We tested whether or not this relation was consistent across the range of body composition encompassing the lean as well as the obese. Individuals participating in community-based comparative research in Nigeria (n = 363), Jamaica (n = 372), and the United States (Maywood, IL; n = 699) had their plasma leptin concentrations and body compositions (with bioelectrical impedance analysis) measured. All participants identified themselves as being black. Body mass index (in kg/m2) ranged from 14 to 62. Large differences in mean plasma leptin were noted across populations for both men and women in Nigeria, Jamaica, and the United States, respectively (men: 2.8, 3.9, and 6.8 microg/L; women: 10.3, 18.6, and 27.7 microg/L). An exponential function fit the relation between percentage body fat or total fat mass and leptin for men and women at each site. For women and men the exponential function with either percentage body fat or total fat mass was of the same shape, but increased by a constant in women, yielding higher leptin concentrations than in men at every level of body fat. On the basis of this broad distribution of body composition, the data suggest an exponential response of leptin to increases in body fat stores, consistent with the development of leptin resistance in individuals developing obesity. These findings likewise confirm that men and women exhibit different set points in terms of leptin production. |
| doi_str_mv | 10.1093/ajcn/67.3.391 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79715580</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002916523182153</els_id><sourcerecordid>79715580</sourcerecordid><originalsourceid>FETCH-LOGICAL-c519t-267c8f6884e86a6908725f606f90310a34d8f412948742dc043aa43c45c20eff3</originalsourceid><addsrcrecordid>eNp1kE1rGzEQhkVpSNy0xx4LSyk9ZR19rT6ObWiTFNMeUp_FWCsFObuSI60L-feRa5NAIKcZeB9eZh6EPhI8J1izc1jbeC7knM2ZJm_QjGimWkaxfItmGGPaaiK6E_SulDXGhHIljtGx5loSRWbo-8JtphAbiH2zSv1DY9O4SSVMIcUm-eZ3uHU5QCxnzS8YIdj_645e3jSrAexdeY-OPAzFfTjMU7T8-ePvxVW7-HN5ffFt0dqO6KmlQlrlhVLcKQFCYyVp5wUWXmNGMDDeK88J1VxJTnuLOQPgzPLOUuy8Z6fo6753k9P91pXJjKFYNwwQXdoWI-tLXadwBT-_ANdpm2O9zVBW9UjdkQq1e8jmVEp23mxyGCE_GILNTqzZiTVCGmaq2Mp_OpRuV6Prn-iDyZp_OeRQLAw-Q7ShPGGUKKVk91zjIRm4zRVZ3hCtJVaMa1Zzuc9dNfkvuGyKDS5a14fs7GT6FF458BEMEJl1</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>231937951</pqid></control><display><type>article</type><title>Leptin and body composition of Nigerians, Jamaicans, and US blacks</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Luke, AH ; Rotimi, CN ; Cooper, RS ; Long, AE ; Forrester, TE ; Wilks, R ; Bennett, FI ; Ogunbiyi, O ; Compton, JA ; Bowsher, RR</creator><creatorcontrib>Luke, AH ; Rotimi, CN ; Cooper, RS ; Long, AE ; Forrester, TE ; Wilks, R ; Bennett, FI ; Ogunbiyi, O ; Compton, JA ; Bowsher, RR</creatorcontrib><description>The role of leptin in humans remains controversial. Leptin concentrations are highly correlated with body fat stores. We tested whether or not this relation was consistent across the range of body composition encompassing the lean as well as the obese. Individuals participating in community-based comparative research in Nigeria (n = 363), Jamaica (n = 372), and the United States (Maywood, IL; n = 699) had their plasma leptin concentrations and body compositions (with bioelectrical impedance analysis) measured. All participants identified themselves as being black. Body mass index (in kg/m2) ranged from 14 to 62. Large differences in mean plasma leptin were noted across populations for both men and women in Nigeria, Jamaica, and the United States, respectively (men: 2.8, 3.9, and 6.8 microg/L; women: 10.3, 18.6, and 27.7 microg/L). An exponential function fit the relation between percentage body fat or total fat mass and leptin for men and women at each site. For women and men the exponential function with either percentage body fat or total fat mass was of the same shape, but increased by a constant in women, yielding higher leptin concentrations than in men at every level of body fat. On the basis of this broad distribution of body composition, the data suggest an exponential response of leptin to increases in body fat stores, consistent with the development of leptin resistance in individuals developing obesity. These findings likewise confirm that men and women exhibit different set points in terms of leptin production.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/67.3.391</identifier><identifier>PMID: 9497181</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Adipose Tissue ; ADIPOSE TISSUES ; Adult ; ANIMAL PROTEINS ; Biological and medical sciences ; BIOLOGICAL DIFFERENCES ; Black or African American ; Black People ; BLOOD PLASMA ; BLOOD PROTEINS ; Body Composition ; BODY FAT ; BODY LEAN MASS ; BODY MASS INDEX ; BODY WEIGHT ; ETHNIC GROUPS ; Female ; HEIGHT ; Humans ; JAMAICA ; Jamaica - ethnology ; Leptin ; Male ; Medical sciences ; MEN ; Metabolic diseases ; Middle Aged ; NIGERIA ; Nigeria - ethnology ; Obesity ; Oils & fats ; Proteins ; Proteins - metabolism ; SEX ; SURVEYS ; United States - ethnology ; USA ; WOMEN</subject><ispartof>The American journal of clinical nutrition, 1998-03, Vol.67 (3), p.391-396</ispartof><rights>1998 American Society for Nutrition.</rights><rights>1998 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Mar 1998</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-267c8f6884e86a6908725f606f90310a34d8f412948742dc043aa43c45c20eff3</citedby><cites>FETCH-LOGICAL-c519t-267c8f6884e86a6908725f606f90310a34d8f412948742dc043aa43c45c20eff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2188875$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9497181$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luke, AH</creatorcontrib><creatorcontrib>Rotimi, CN</creatorcontrib><creatorcontrib>Cooper, RS</creatorcontrib><creatorcontrib>Long, AE</creatorcontrib><creatorcontrib>Forrester, TE</creatorcontrib><creatorcontrib>Wilks, R</creatorcontrib><creatorcontrib>Bennett, FI</creatorcontrib><creatorcontrib>Ogunbiyi, O</creatorcontrib><creatorcontrib>Compton, JA</creatorcontrib><creatorcontrib>Bowsher, RR</creatorcontrib><title>Leptin and body composition of Nigerians, Jamaicans, and US blacks</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>The role of leptin in humans remains controversial. Leptin concentrations are highly correlated with body fat stores. We tested whether or not this relation was consistent across the range of body composition encompassing the lean as well as the obese. Individuals participating in community-based comparative research in Nigeria (n = 363), Jamaica (n = 372), and the United States (Maywood, IL; n = 699) had their plasma leptin concentrations and body compositions (with bioelectrical impedance analysis) measured. All participants identified themselves as being black. Body mass index (in kg/m2) ranged from 14 to 62. Large differences in mean plasma leptin were noted across populations for both men and women in Nigeria, Jamaica, and the United States, respectively (men: 2.8, 3.9, and 6.8 microg/L; women: 10.3, 18.6, and 27.7 microg/L). An exponential function fit the relation between percentage body fat or total fat mass and leptin for men and women at each site. For women and men the exponential function with either percentage body fat or total fat mass was of the same shape, but increased by a constant in women, yielding higher leptin concentrations than in men at every level of body fat. On the basis of this broad distribution of body composition, the data suggest an exponential response of leptin to increases in body fat stores, consistent with the development of leptin resistance in individuals developing obesity. These findings likewise confirm that men and women exhibit different set points in terms of leptin production.</description><subject>Adipose Tissue</subject><subject>ADIPOSE TISSUES</subject><subject>Adult</subject><subject>ANIMAL PROTEINS</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL DIFFERENCES</subject><subject>Black or African American</subject><subject>Black People</subject><subject>BLOOD PLASMA</subject><subject>BLOOD PROTEINS</subject><subject>Body Composition</subject><subject>BODY FAT</subject><subject>BODY LEAN MASS</subject><subject>BODY MASS INDEX</subject><subject>BODY WEIGHT</subject><subject>ETHNIC GROUPS</subject><subject>Female</subject><subject>HEIGHT</subject><subject>Humans</subject><subject>JAMAICA</subject><subject>Jamaica - ethnology</subject><subject>Leptin</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MEN</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>NIGERIA</subject><subject>Nigeria - ethnology</subject><subject>Obesity</subject><subject>Oils & fats</subject><subject>Proteins</subject><subject>Proteins - metabolism</subject><subject>SEX</subject><subject>SURVEYS</subject><subject>United States - ethnology</subject><subject>USA</subject><subject>WOMEN</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1rGzEQhkVpSNy0xx4LSyk9ZR19rT6ObWiTFNMeUp_FWCsFObuSI60L-feRa5NAIKcZeB9eZh6EPhI8J1izc1jbeC7knM2ZJm_QjGimWkaxfItmGGPaaiK6E_SulDXGhHIljtGx5loSRWbo-8JtphAbiH2zSv1DY9O4SSVMIcUm-eZ3uHU5QCxnzS8YIdj_645e3jSrAexdeY-OPAzFfTjMU7T8-ePvxVW7-HN5ffFt0dqO6KmlQlrlhVLcKQFCYyVp5wUWXmNGMDDeK88J1VxJTnuLOQPgzPLOUuy8Z6fo6753k9P91pXJjKFYNwwQXdoWI-tLXadwBT-_ANdpm2O9zVBW9UjdkQq1e8jmVEp23mxyGCE_GILNTqzZiTVCGmaq2Mp_OpRuV6Prn-iDyZp_OeRQLAw-Q7ShPGGUKKVk91zjIRm4zRVZ3hCtJVaMa1Zzuc9dNfkvuGyKDS5a14fs7GT6FF458BEMEJl1</recordid><startdate>19980301</startdate><enddate>19980301</enddate><creator>Luke, AH</creator><creator>Rotimi, CN</creator><creator>Cooper, RS</creator><creator>Long, AE</creator><creator>Forrester, TE</creator><creator>Wilks, R</creator><creator>Bennett, FI</creator><creator>Ogunbiyi, O</creator><creator>Compton, JA</creator><creator>Bowsher, RR</creator><general>Elsevier Inc</general><general>American Society for Clinical Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19980301</creationdate><title>Leptin and body composition of Nigerians, Jamaicans, and US blacks</title><author>Luke, AH ; Rotimi, CN ; Cooper, RS ; Long, AE ; Forrester, TE ; Wilks, R ; Bennett, FI ; Ogunbiyi, O ; Compton, JA ; Bowsher, RR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-267c8f6884e86a6908725f606f90310a34d8f412948742dc043aa43c45c20eff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adipose Tissue</topic><topic>ADIPOSE TISSUES</topic><topic>Adult</topic><topic>ANIMAL PROTEINS</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL DIFFERENCES</topic><topic>Black or African American</topic><topic>Black People</topic><topic>BLOOD PLASMA</topic><topic>BLOOD PROTEINS</topic><topic>Body Composition</topic><topic>BODY FAT</topic><topic>BODY LEAN MASS</topic><topic>BODY MASS INDEX</topic><topic>BODY WEIGHT</topic><topic>ETHNIC GROUPS</topic><topic>Female</topic><topic>HEIGHT</topic><topic>Humans</topic><topic>JAMAICA</topic><topic>Jamaica - ethnology</topic><topic>Leptin</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MEN</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>NIGERIA</topic><topic>Nigeria - ethnology</topic><topic>Obesity</topic><topic>Oils & fats</topic><topic>Proteins</topic><topic>Proteins - metabolism</topic><topic>SEX</topic><topic>SURVEYS</topic><topic>United States - ethnology</topic><topic>USA</topic><topic>WOMEN</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luke, AH</creatorcontrib><creatorcontrib>Rotimi, CN</creatorcontrib><creatorcontrib>Cooper, RS</creatorcontrib><creatorcontrib>Long, AE</creatorcontrib><creatorcontrib>Forrester, TE</creatorcontrib><creatorcontrib>Wilks, R</creatorcontrib><creatorcontrib>Bennett, FI</creatorcontrib><creatorcontrib>Ogunbiyi, O</creatorcontrib><creatorcontrib>Compton, JA</creatorcontrib><creatorcontrib>Bowsher, RR</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luke, AH</au><au>Rotimi, CN</au><au>Cooper, RS</au><au>Long, AE</au><au>Forrester, TE</au><au>Wilks, R</au><au>Bennett, FI</au><au>Ogunbiyi, O</au><au>Compton, JA</au><au>Bowsher, RR</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leptin and body composition of Nigerians, Jamaicans, and US blacks</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1998-03-01</date><risdate>1998</risdate><volume>67</volume><issue>3</issue><spage>391</spage><epage>396</epage><pages>391-396</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>The role of leptin in humans remains controversial. Leptin concentrations are highly correlated with body fat stores. We tested whether or not this relation was consistent across the range of body composition encompassing the lean as well as the obese. Individuals participating in community-based comparative research in Nigeria (n = 363), Jamaica (n = 372), and the United States (Maywood, IL; n = 699) had their plasma leptin concentrations and body compositions (with bioelectrical impedance analysis) measured. All participants identified themselves as being black. Body mass index (in kg/m2) ranged from 14 to 62. Large differences in mean plasma leptin were noted across populations for both men and women in Nigeria, Jamaica, and the United States, respectively (men: 2.8, 3.9, and 6.8 microg/L; women: 10.3, 18.6, and 27.7 microg/L). An exponential function fit the relation between percentage body fat or total fat mass and leptin for men and women at each site. For women and men the exponential function with either percentage body fat or total fat mass was of the same shape, but increased by a constant in women, yielding higher leptin concentrations than in men at every level of body fat. On the basis of this broad distribution of body composition, the data suggest an exponential response of leptin to increases in body fat stores, consistent with the development of leptin resistance in individuals developing obesity. These findings likewise confirm that men and women exhibit different set points in terms of leptin production.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>9497181</pmid><doi>10.1093/ajcn/67.3.391</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9165 |
| ispartof | The American journal of clinical nutrition, 1998-03, Vol.67 (3), p.391-396 |
| issn | 0002-9165 1938-3207 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79715580 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adipose Tissue ADIPOSE TISSUES Adult ANIMAL PROTEINS Biological and medical sciences BIOLOGICAL DIFFERENCES Black or African American Black People BLOOD PLASMA BLOOD PROTEINS Body Composition BODY FAT BODY LEAN MASS BODY MASS INDEX BODY WEIGHT ETHNIC GROUPS Female HEIGHT Humans JAMAICA Jamaica - ethnology Leptin Male Medical sciences MEN Metabolic diseases Middle Aged NIGERIA Nigeria - ethnology Obesity Oils & fats Proteins Proteins - metabolism SEX SURVEYS United States - ethnology USA WOMEN |
| title | Leptin and body composition of Nigerians, Jamaicans, and US blacks |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T00%3A51%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Leptin%20and%20body%20composition%20of%20Nigerians,%20Jamaicans,%20and%20US%20blacks&rft.jtitle=The%20American%20journal%20of%20clinical%20nutrition&rft.au=Luke,%20AH&rft.date=1998-03-01&rft.volume=67&rft.issue=3&rft.spage=391&rft.epage=396&rft.pages=391-396&rft.issn=0002-9165&rft.eissn=1938-3207&rft.coden=AJCNAC&rft_id=info:doi/10.1093/ajcn/67.3.391&rft_dat=%3Cproquest_cross%3E79715580%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=231937951&rft_id=info:pmid/9497181&rft_els_id=S0002916523182153&rfr_iscdi=true |