Metronidazole prophylaxis to prevent infections after total abdominal hysterectomy
Methods. In a randomized double-blind study, 134 patients were given 500 mg metronidazole as an intravenous infusion immediately before operation for abdominal total hysterectomy and again 8 hours later and 124 patients received placebo. Results. There was more wound infection, postoperative hospita...
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| Veröffentlicht in: | Acta obstetricia et gynecologica Scandinavica 1998, Vol.77 (1), p.116-119 |
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| container_title | Acta obstetricia et gynecologica Scandinavica |
| container_volume | 77 |
| creator | Henriksson, Lars Colling-Saltin, Ann-Sofie Frick, Göran Kullander, Stig Sandholm, Lars-Erik Ursing, Jan Cederberg, Åke |
| description | Methods. In a randomized double-blind study, 134 patients were given 500 mg metronidazole as an intravenous infusion immediately before operation for abdominal total hysterectomy and again 8 hours later and 124 patients received placebo.
Results. There was more wound infection, postoperative hospitalization was longer and the sedimentation rate on the sixth postoperative day was significantly higher in the placebo group. There was no difference in postoperative temperature. Postoperative wound infections occurred in 12% in the placebo group and 6% in the metronidazole group. Eight percent in the total material had urinary tract infections, the diagnosis was based on urine cultures.
Conclusions. Prophylaxis with intravenous infusion of metronidazole is recommended in total hysterectomies. |
| doi_str_mv | 10.1080/00016349808565824 |
| format | Article |
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Results. There was more wound infection, postoperative hospitalization was longer and the sedimentation rate on the sixth postoperative day was significantly higher in the placebo group. There was no difference in postoperative temperature. Postoperative wound infections occurred in 12% in the placebo group and 6% in the metronidazole group. Eight percent in the total material had urinary tract infections, the diagnosis was based on urine cultures.
Conclusions. Prophylaxis with intravenous infusion of metronidazole is recommended in total hysterectomies.</description><identifier>ISSN: 0001-6349</identifier><identifier>EISSN: 1600-0412</identifier><identifier>DOI: 10.1080/00016349808565824</identifier><identifier>PMID: 9492731</identifier><identifier>CODEN: AOGSAE</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject><![CDATA[Anti-Infective Agents - administration & dosage ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacterial Infections - prevention & control ; Biological and medical sciences ; Double-Blind Method ; Female ; Humans ; Hysterectomy ; Infusions, Intravenous ; Medical sciences ; Metronidazole - administration & dosage ; Pharmacology. Drug treatments ; Postoperative Complications - prevention & control ; Premedication ; Surgical Wound Infection - prevention & control ; Urinary Tract Infections - etiology ; Urinary Tract Infections - prevention & control]]></subject><ispartof>Acta obstetricia et gynecologica Scandinavica, 1998, Vol.77 (1), p.116-119</ispartof><rights>1998 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1998</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-3cd06b99d557318a46c3fc3662901120ee43c2d5aea021b46506cbbb19ac4db03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2134377$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9492731$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Henriksson, Lars</creatorcontrib><creatorcontrib>Colling-Saltin, Ann-Sofie</creatorcontrib><creatorcontrib>Frick, Göran</creatorcontrib><creatorcontrib>Kullander, Stig</creatorcontrib><creatorcontrib>Sandholm, Lars-Erik</creatorcontrib><creatorcontrib>Ursing, Jan</creatorcontrib><creatorcontrib>Cederberg, Åke</creatorcontrib><title>Metronidazole prophylaxis to prevent infections after total abdominal hysterectomy</title><title>Acta obstetricia et gynecologica Scandinavica</title><addtitle>Acta Obstet Gynecol Scand</addtitle><description>Methods. In a randomized double-blind study, 134 patients were given 500 mg metronidazole as an intravenous infusion immediately before operation for abdominal total hysterectomy and again 8 hours later and 124 patients received placebo.
Results. There was more wound infection, postoperative hospitalization was longer and the sedimentation rate on the sixth postoperative day was significantly higher in the placebo group. There was no difference in postoperative temperature. Postoperative wound infections occurred in 12% in the placebo group and 6% in the metronidazole group. Eight percent in the total material had urinary tract infections, the diagnosis was based on urine cultures.
Conclusions. Prophylaxis with intravenous infusion of metronidazole is recommended in total hysterectomies.</description><subject>Anti-Infective Agents - administration & dosage</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacterial Infections - prevention & control</subject><subject>Biological and medical sciences</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Hysterectomy</subject><subject>Infusions, Intravenous</subject><subject>Medical sciences</subject><subject>Metronidazole - administration & dosage</subject><subject>Pharmacology. Drug treatments</subject><subject>Postoperative Complications - prevention & control</subject><subject>Premedication</subject><subject>Surgical Wound Infection - prevention & control</subject><subject>Urinary Tract Infections - etiology</subject><subject>Urinary Tract Infections - prevention & control</subject><issn>0001-6349</issn><issn>1600-0412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMoun78AA9CD-KtOvlo2uJJxC9QBNFzmaZTtkvbrElWXH-9WXbZi-BpZvI-M7x5GTvlcMmhgCsA4FqqsoAi01kh1A6bcA2QguJil01WeroCDtih97M4iVwV-2y_VKXIJZ-wtxcKzo5dgz-2p2Tu7Hy67PG780mwcaQvGkPSjS2Z0NnRJ9gGclEL2CdYN3boxthNlz4-R8YOy2O212Lv6WRTj9jH_d377WP6_PrwdHvznBqZ5yGVpgFdl2WTZdFJgUob2RqptSiBcwFEShrRZEgIgtdKZ6BNXde8RKOaGuQRu1jfjaY_F-RDNXTeUN_jSHbhq7zMecZBRZCvQeOs947aau66Ad2y4lCtcqz-5Bh3zjbHF_VAzXZjE1zUzzc6eoN963A0nd9igksVfxmx6zUWE7RuwClhH6YGHVUzu3AxOv-PiV_iQY29</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>Henriksson, Lars</creator><creator>Colling-Saltin, Ann-Sofie</creator><creator>Frick, Göran</creator><creator>Kullander, Stig</creator><creator>Sandholm, Lars-Erik</creator><creator>Ursing, Jan</creator><creator>Cederberg, Åke</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1998</creationdate><title>Metronidazole prophylaxis to prevent infections after total abdominal hysterectomy</title><author>Henriksson, Lars ; Colling-Saltin, Ann-Sofie ; Frick, Göran ; Kullander, Stig ; Sandholm, Lars-Erik ; Ursing, Jan ; Cederberg, Åke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-3cd06b99d557318a46c3fc3662901120ee43c2d5aea021b46506cbbb19ac4db03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Anti-Infective Agents - administration & dosage</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Bacterial Infections - prevention & control</topic><topic>Biological and medical sciences</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Hysterectomy</topic><topic>Infusions, Intravenous</topic><topic>Medical sciences</topic><topic>Metronidazole - administration & dosage</topic><topic>Pharmacology. Drug treatments</topic><topic>Postoperative Complications - prevention & control</topic><topic>Premedication</topic><topic>Surgical Wound Infection - prevention & control</topic><topic>Urinary Tract Infections - etiology</topic><topic>Urinary Tract Infections - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Henriksson, Lars</creatorcontrib><creatorcontrib>Colling-Saltin, Ann-Sofie</creatorcontrib><creatorcontrib>Frick, Göran</creatorcontrib><creatorcontrib>Kullander, Stig</creatorcontrib><creatorcontrib>Sandholm, Lars-Erik</creatorcontrib><creatorcontrib>Ursing, Jan</creatorcontrib><creatorcontrib>Cederberg, Åke</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Henriksson, Lars</au><au>Colling-Saltin, Ann-Sofie</au><au>Frick, Göran</au><au>Kullander, Stig</au><au>Sandholm, Lars-Erik</au><au>Ursing, Jan</au><au>Cederberg, Åke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metronidazole prophylaxis to prevent infections after total abdominal hysterectomy</atitle><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle><addtitle>Acta Obstet Gynecol Scand</addtitle><date>1998</date><risdate>1998</risdate><volume>77</volume><issue>1</issue><spage>116</spage><epage>119</epage><pages>116-119</pages><issn>0001-6349</issn><eissn>1600-0412</eissn><coden>AOGSAE</coden><abstract>Methods. In a randomized double-blind study, 134 patients were given 500 mg metronidazole as an intravenous infusion immediately before operation for abdominal total hysterectomy and again 8 hours later and 124 patients received placebo.
Results. There was more wound infection, postoperative hospitalization was longer and the sedimentation rate on the sixth postoperative day was significantly higher in the placebo group. There was no difference in postoperative temperature. Postoperative wound infections occurred in 12% in the placebo group and 6% in the metronidazole group. Eight percent in the total material had urinary tract infections, the diagnosis was based on urine cultures.
Conclusions. Prophylaxis with intravenous infusion of metronidazole is recommended in total hysterectomies.</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><pmid>9492731</pmid><doi>10.1080/00016349808565824</doi><tpages>4</tpages></addata></record> |
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| ispartof | Acta obstetricia et gynecologica Scandinavica, 1998, Vol.77 (1), p.116-119 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Anti-Infective Agents - administration & dosage Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial Infections - prevention & control Biological and medical sciences Double-Blind Method Female Humans Hysterectomy Infusions, Intravenous Medical sciences Metronidazole - administration & dosage Pharmacology. Drug treatments Postoperative Complications - prevention & control Premedication Surgical Wound Infection - prevention & control Urinary Tract Infections - etiology Urinary Tract Infections - prevention & control |
| title | Metronidazole prophylaxis to prevent infections after total abdominal hysterectomy |
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