Role of PML in Cell Growth and the Retinoic Acid Pathway

The PML gene is fused to the retinoic acid receptor α (RARα) gene in chromosomal translocations associated with acute promyelocytic leukemia (APL). Ablation of murine PML protein by homologous recombination revealed that PML regulates hemopoietic differentiation and controls cell growth and tumorige...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1998-03, Vol.279 (5356), p.1547-1551
Hauptverfasser:	Wang, Zhu Gang, Delva, Laurent, Gaboli, Mirella, Rivi, Roberta, Giorgio, Marco, Cordon-Cardo, Carlos, Grosveld, Frank, Pandolfi, Pier Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Acute leukemia, Promyelocytic Acute myelocytic leukemia Animals Apoptosis B lymphocytes Biological and medical sciences Carcinogenesis Cell Differentiation - drug effects Cell Division Cell growth Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic Cells, Cultured Cellular biology Cultured cells Cyclin-Dependent Kinase Inhibitor p21 Cyclins - genetics Female Fibroblasts - cytology Fundamental and applied biological sciences. Psychology Gene Targeting Genes Genetic aspects Granulocytes - cytology Hematopoiesis Hematopoietic Stem Cells - cytology Individualized Instruction Leukemia, Promyelocytic, Acute - pathology Logical Thinking Lymphoma Male Mice Molecular and cellular biology Monocytes - cytology Myeloid cells Neoplasm Proteins - genetics Neoplasm Proteins - physiology Neoplasms, Experimental - etiology Nuclear Proteins Oncogene Proteins, Fusion - physiology Papilloma Pathology Promyelocytic Leukemia Protein Stem cells T lymphocytes Transcription Factors - genetics Transcription Factors - physiology Transcriptional Activation Tretinoin - pharmacology Tretinoin - physiology Tumor Suppressor Proteins Tumors
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