Evidence for a cholinergic mechanism of “learned” changes in the responses of barrel field neurons of the awake and undrugged rat
Due to its functional importance and its large and highly differentiated central projections, the vibrissal system of rodents is a prime object for the study of sensory plasticity, especially at the cortical level: the representation of vibrissae in the “barrel field”, a part of the somatic cortex,...
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| Veröffentlicht in: | Neuroscience 1990, Vol.34 (1), p.1-8 |
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| creator | Delacour, J. Houcine, O. Costa, J.C. |
| description | Due to its functional importance and its large and highly differentiated central projections, the vibrissal system of rodents is a prime object for the study of sensory plasticity, especially at the cortical level: the representation of vibrissae in the “barrel field”, a part of the somatic cortex, is exceptionally precise and is susceptible to experience-induced changes. In a previous series of experiments, we found that a sensory-sensory conditioning procedure, pairing two vibrissal stimulations, produces significant changes in responses of single neurons of the barrel field in the chronic awake and undrugged rat:
(1) the appearance of an excitatory response to a stimulus that was ineffective before pairing (“conditioned response”).
(2) the modifications of pre-existing responses consisting of the suppression of afferent inhibition and the appearance of long-latency excitatory components.
We report here that the micro-iontophoretic application of atropine abolishes “conditioned responses” and restores afferent inhibition. Acetylcholine facilitates an enlargement of the receptive field and induces a sustained mode of discharge to stimuli. These data provide a new and direct support to the hypothesis that cholinergic mechanisms are involved in the sensory cortex plasticity. |
| doi_str_mv | 10.1016/0306-4522(90)90299-J |
| format | Article |
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(1) the appearance of an excitatory response to a stimulus that was ineffective before pairing (“conditioned response”).
(2) the modifications of pre-existing responses consisting of the suppression of afferent inhibition and the appearance of long-latency excitatory components.
We report here that the micro-iontophoretic application of atropine abolishes “conditioned responses” and restores afferent inhibition. Acetylcholine facilitates an enlargement of the receptive field and induces a sustained mode of discharge to stimuli. These data provide a new and direct support to the hypothesis that cholinergic mechanisms are involved in the sensory cortex plasticity.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/0306-4522(90)90299-J</identifier><identifier>PMID: 2325845</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>acetylcholine ; Acetylcholine - pharmacology ; ACh ; afferent inhibition ; Animals ; Atropine - pharmacology ; autocorrelogram ; Biological and medical sciences ; ChAT ; choline acetyltransferase ; Cholinergic Fibers - drug effects ; Cholinergic Fibers - physiology ; EEG ; electroencephalogram ; EPSP ; Evoked Potentials, Somatosensory - drug effects ; excitatory postsynaptic potential ; Fast Fourier Transform ; FFT ; first stimulus ; Fundamental and applied biological sciences. Psychology ; IIH ; inhibitory postsynaptic potential ; interspike interval histogram ; IPSP ; peristimulus time histogram ; PSTH ; Rats ; second stimulus ; Somatosensory Cortex - physiology ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Vertebrates: nervous system and sense organs ; Vibrissae</subject><ispartof>Neuroscience, 1990, Vol.34 (1), p.1-8</ispartof><rights>1990 IBRO</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-d5d9941875e5485c8b9564358637ffe700a243e40e649e5ea9adacc6ecf0c7c73</citedby><cites>FETCH-LOGICAL-c418t-d5d9941875e5485c8b9564358637ffe700a243e40e649e5ea9adacc6ecf0c7c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0306-4522(90)90299-J$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,4022,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19248527$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2325845$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Delacour, J.</creatorcontrib><creatorcontrib>Houcine, O.</creatorcontrib><creatorcontrib>Costa, J.C.</creatorcontrib><title>Evidence for a cholinergic mechanism of “learned” changes in the responses of barrel field neurons of the awake and undrugged rat</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Due to its functional importance and its large and highly differentiated central projections, the vibrissal system of rodents is a prime object for the study of sensory plasticity, especially at the cortical level: the representation of vibrissae in the “barrel field”, a part of the somatic cortex, is exceptionally precise and is susceptible to experience-induced changes. In a previous series of experiments, we found that a sensory-sensory conditioning procedure, pairing two vibrissal stimulations, produces significant changes in responses of single neurons of the barrel field in the chronic awake and undrugged rat:
(1) the appearance of an excitatory response to a stimulus that was ineffective before pairing (“conditioned response”).
(2) the modifications of pre-existing responses consisting of the suppression of afferent inhibition and the appearance of long-latency excitatory components.
We report here that the micro-iontophoretic application of atropine abolishes “conditioned responses” and restores afferent inhibition. Acetylcholine facilitates an enlargement of the receptive field and induces a sustained mode of discharge to stimuli. These data provide a new and direct support to the hypothesis that cholinergic mechanisms are involved in the sensory cortex plasticity.</description><subject>acetylcholine</subject><subject>Acetylcholine - pharmacology</subject><subject>ACh</subject><subject>afferent inhibition</subject><subject>Animals</subject><subject>Atropine - pharmacology</subject><subject>autocorrelogram</subject><subject>Biological and medical sciences</subject><subject>ChAT</subject><subject>choline acetyltransferase</subject><subject>Cholinergic Fibers - drug effects</subject><subject>Cholinergic Fibers - physiology</subject><subject>EEG</subject><subject>electroencephalogram</subject><subject>EPSP</subject><subject>Evoked Potentials, Somatosensory - drug effects</subject><subject>excitatory postsynaptic potential</subject><subject>Fast Fourier Transform</subject><subject>FFT</subject><subject>first stimulus</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>IIH</subject><subject>inhibitory postsynaptic potential</subject><subject>interspike interval histogram</subject><subject>IPSP</subject><subject>peristimulus time histogram</subject><subject>PSTH</subject><subject>Rats</subject><subject>second stimulus</subject><subject>Somatosensory Cortex - physiology</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Vibrissae</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u3CAUhVHVKpmkfYNEYtMqXbjFBozZRKqi9CeK1E27RgxcZkhtPAU7UXbZ5C3Sl8uTFDqjdNeyAHTPdw8_B6GjmryrSd2-J5S0FeNNcyLJW0kaKauLZ2hRd4JWgjP2HC2ekH10kNIVyYMzuof2GtrwjvEFuj-_9haCAezGiDU267H3AeLKGzyAWevg04BHhx_vHnrQMYB9vPuFi7CChH3A0xpwhLQZQ8qFTC51jNBj56G3OMAcs1LqBdQ3-keeg8VzsHFercDiqKeX6IXTfYJXu_UQff94_u3sc3X59dOXsw-XlWF1N1WWWynzTnDgrOOmW0reMsq7lgrnQBCiG0aBEWiZBA5aaquNacE4YoQR9BC92fpu4vhzhjSpwScDfa8DjHNSQoqacUr-C9aci66TxZFtQRPHlCI4tYl-0PFW1USVmFTJQJUMlCTqT0zqIrcd7_zn5QD2qWmXS9Zf73SdjO5d1MH49NdbNvn9TTn-dMtB_rVrD1El40uc1kcwk7Kj__dFfgMuXLGC</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Delacour, J.</creator><creator>Houcine, O.</creator><creator>Costa, J.C.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>Evidence for a cholinergic mechanism of “learned” changes in the responses of barrel field neurons of the awake and undrugged rat</title><author>Delacour, J. ; Houcine, O. ; Costa, J.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-d5d9941875e5485c8b9564358637ffe700a243e40e649e5ea9adacc6ecf0c7c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>acetylcholine</topic><topic>Acetylcholine - pharmacology</topic><topic>ACh</topic><topic>afferent inhibition</topic><topic>Animals</topic><topic>Atropine - pharmacology</topic><topic>autocorrelogram</topic><topic>Biological and medical sciences</topic><topic>ChAT</topic><topic>choline acetyltransferase</topic><topic>Cholinergic Fibers - drug effects</topic><topic>Cholinergic Fibers - physiology</topic><topic>EEG</topic><topic>electroencephalogram</topic><topic>EPSP</topic><topic>Evoked Potentials, Somatosensory - drug effects</topic><topic>excitatory postsynaptic potential</topic><topic>Fast Fourier Transform</topic><topic>FFT</topic><topic>first stimulus</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>IIH</topic><topic>inhibitory postsynaptic potential</topic><topic>interspike interval histogram</topic><topic>IPSP</topic><topic>peristimulus time histogram</topic><topic>PSTH</topic><topic>Rats</topic><topic>second stimulus</topic><topic>Somatosensory Cortex - physiology</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Vibrissae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Delacour, J.</creatorcontrib><creatorcontrib>Houcine, O.</creatorcontrib><creatorcontrib>Costa, J.C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Delacour, J.</au><au>Houcine, O.</au><au>Costa, J.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for a cholinergic mechanism of “learned” changes in the responses of barrel field neurons of the awake and undrugged rat</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>1990</date><risdate>1990</risdate><volume>34</volume><issue>1</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Due to its functional importance and its large and highly differentiated central projections, the vibrissal system of rodents is a prime object for the study of sensory plasticity, especially at the cortical level: the representation of vibrissae in the “barrel field”, a part of the somatic cortex, is exceptionally precise and is susceptible to experience-induced changes. In a previous series of experiments, we found that a sensory-sensory conditioning procedure, pairing two vibrissal stimulations, produces significant changes in responses of single neurons of the barrel field in the chronic awake and undrugged rat:
(1) the appearance of an excitatory response to a stimulus that was ineffective before pairing (“conditioned response”).
(2) the modifications of pre-existing responses consisting of the suppression of afferent inhibition and the appearance of long-latency excitatory components.
We report here that the micro-iontophoretic application of atropine abolishes “conditioned responses” and restores afferent inhibition. Acetylcholine facilitates an enlargement of the receptive field and induces a sustained mode of discharge to stimuli. These data provide a new and direct support to the hypothesis that cholinergic mechanisms are involved in the sensory cortex plasticity.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>2325845</pmid><doi>10.1016/0306-4522(90)90299-J</doi><tpages>8</tpages></addata></record> |
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| subjects | acetylcholine Acetylcholine - pharmacology ACh afferent inhibition Animals Atropine - pharmacology autocorrelogram Biological and medical sciences ChAT choline acetyltransferase Cholinergic Fibers - drug effects Cholinergic Fibers - physiology EEG electroencephalogram EPSP Evoked Potentials, Somatosensory - drug effects excitatory postsynaptic potential Fast Fourier Transform FFT first stimulus Fundamental and applied biological sciences. Psychology IIH inhibitory postsynaptic potential interspike interval histogram IPSP peristimulus time histogram PSTH Rats second stimulus Somatosensory Cortex - physiology Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Vertebrates: nervous system and sense organs Vibrissae |
| title | Evidence for a cholinergic mechanism of “learned” changes in the responses of barrel field neurons of the awake and undrugged rat |
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