The Effective Free Fraction of Estradiol and Xenoestrogens in Human Serum Measured by Whole Cell Uptake Assays: Physiology of Delivery Modifies Estrogenic Activity

Abstract The biological activity of natural estrogens is influenced by the degree to which they bind to serum proteins. To determine directly how serum affected the uptake of estradiol, we compared the whole cell uptake of [3H]estradiol in intact MCF-7 human breast cancer cells from serum-free mediu...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 1998-03, Vol.217 (3), p.300-309
Hauptverfasser:	Nagel, Susan C., Vom Saal, Frederick S., Welshons, Wade V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzhydryl Compounds Chromatography, High Pressure Liquid Estradiol - blood Estradiol - metabolism Estrogens, Non-Steroidal - blood Humans Isoflavones Male Phenols - blood Phytoestrogens Plant Preparations Receptors, Estrogen - metabolism Tumor Cells, Cultured
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