Structural Dynamics of HIV-1 Rev and Its Complexes with RRE and 5S RNA

The Rev protein of the human immunodeficiency virus type 1 (HIV-1) has been studied by time-resolved fluorescence spectroscopy. The single tryptophan residue of Rev, Trp45, located within the arginine-rich RNA-binding domain of the protein, was utilized as an intrinsic spectroscopic probe. In additi...

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Veröffentlicht in:	Biochemistry (Easton) 1998-02, Vol.37 (7), p.1800-1809
Hauptverfasser:	Lam, Wai-Chung, Seifert, Jan M, Amberger, Franz, Graf, Christine, Auer, Manfred, Millar, David P
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Base Sequence Binding Sites Fluorescence Polarization Gene Products, rev - chemistry Gene Products, rev - genetics Gene Products, rev - metabolism HIV-1 - chemistry Macromolecular Substances Molecular Sequence Data Nuclear Proteins - chemistry Nuclear Proteins - metabolism Peptides - chemistry Peptides - genetics rev Gene Products, Human Immunodeficiency Virus RNA, Ribosomal, 5S - chemistry RNA, Ribosomal, 5S - metabolism Sequence Deletion Spectrometry, Fluorescence Tryptophan
Online-Zugang:	Volltext
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