In Vitro Evidence of Tissue Susceptibility Rhythms. I. Temporal Variation in Effect of Potassium Chloride and Phenylephrine on Rat Aorta
In this study, time-dependent variations in the in vitro sensitivity of rat thoracic aorta rings to potassium chloride (KC1) and phenylephrine (Phe) were investigated. Animals were synchronized with a 12h light and 12h darkness (lights on 08:00-20:00) schedule, and thoracic aortas were obtained at s...
Gespeichert in:
| Veröffentlicht in: | Chronobiology international 1998, Vol.15 (1), p.39-48 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 48 |
|---|---|
| container_issue | 1 |
| container_start_page | 39 |
| container_title | Chronobiology international |
| container_volume | 15 |
| creator | Görgün, Cem Z. Keskil, Zuhal Aktuna Hodoglugil, UgUr Ercan, Z. Sevim Abaciog'lu, Nurettin Zengil, Hakan |
| description | In this study, time-dependent variations in the in vitro sensitivity of rat thoracic aorta rings to potassium chloride (KC1) and phenylephrine (Phe) were investigated. Animals were synchronized with a 12h light and 12h darkness (lights on 08:00-20:00) schedule, and thoracic aortas were obtained at six different times of the day (1, 5, 9, 13, 17, and 21 hours after lights on). In order to avoid endothelial influence, all experiments were performed in endothelium-denuded preparations. Responses to KC1 showed time-dependent variations in all the concentrations used. Phe-induced contractions also exhibited time-dependent differences. The rhythmic pattern of Phe responses did not change with the presence of the ar adrenergic antagonist prazosin. In addition, both the ECio values of KC1 and Phe, and also the ATB values of prazosin, displayed rhythmicity. In conclusion, time of obtaining tissues is an important factor for experimental standardization in, at least, vascular smooth muscle preparations. (Chornobio Interna-tional, 15(1)39-48, 1998) |
| doi_str_mv | 10.3109/07420529808998668 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_79713726</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79713726</sourcerecordid><originalsourceid>FETCH-LOGICAL-c430t-d651141c86b9a280c9c93700569414f6cc53bbceb61e512f8f1f922e7d645f3</originalsourceid><addsrcrecordid>eNp9kMtq3DAYhUVpSadJH6CLghalO091sWWLdhOGaTsQSEiGbI0sS1hBllxJbvEb9LGrYaaBEMhKi3P5dT4APmC0phjxL6guCaoIb1DDecNY8wqscEWqgqGavgarg15kQ_MWvIvxASHUIEbPwBkvOa0xXYG_OwfvTQoebn-bXjmpoNdwb2KcFbybo1RTMp2xJi3wdljSMMY13K3hXo2TD8LCexGMSMY7aBzcaq1kOjTc-CRiNPMIN4P1IVdD4Xp4Myi3WDUNwbh8ycFbkeClD0lcgDda2Kjen95zcPd9u9_8LK6uf-w2l1eFLClKRc8qjEssG9ZxQRokucxLEKoYL3GpmZQV7TqpOoZVhYluNNacEFX3rKw0PQefj61T8L9mFVM7mrzRWuGUn2Nb80ylJiwb8dEog48xKN1OwYwiLC1G7YF9-4x9znw8lc_dqPrHxAl21j-ddBGlsDoIJ018tBHMEEGHmm9Hm3Hah1H88cH2bRJL5vg_Q1_6xdcn8UEJmwYpgmof_BxchvvChn_FCbG4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79713726</pqid></control><display><type>article</type><title>In Vitro Evidence of Tissue Susceptibility Rhythms. I. Temporal Variation in Effect of Potassium Chloride and Phenylephrine on Rat Aorta</title><source>MEDLINE</source><source>Taylor & Francis:Master (3349 titles)</source><creator>Görgün, Cem Z. ; Keskil, Zuhal Aktuna ; Hodoglugil, UgUr ; Ercan, Z. Sevim ; Abaciog'lu, Nurettin ; Zengil, Hakan</creator><creatorcontrib>Görgün, Cem Z. ; Keskil, Zuhal Aktuna ; Hodoglugil, UgUr ; Ercan, Z. Sevim ; Abaciog'lu, Nurettin ; Zengil, Hakan</creatorcontrib><description>In this study, time-dependent variations in the in vitro sensitivity of rat thoracic aorta rings to potassium chloride (KC1) and phenylephrine (Phe) were investigated. Animals were synchronized with a 12h light and 12h darkness (lights on 08:00-20:00) schedule, and thoracic aortas were obtained at six different times of the day (1, 5, 9, 13, 17, and 21 hours after lights on). In order to avoid endothelial influence, all experiments were performed in endothelium-denuded preparations. Responses to KC1 showed time-dependent variations in all the concentrations used. Phe-induced contractions also exhibited time-dependent differences. The rhythmic pattern of Phe responses did not change with the presence of the ar adrenergic antagonist prazosin. In addition, both the ECio values of KC1 and Phe, and also the ATB values of prazosin, displayed rhythmicity. In conclusion, time of obtaining tissues is an important factor for experimental standardization in, at least, vascular smooth muscle preparations. (Chornobio Interna-tional, 15(1)39-48, 1998)</description><identifier>ISSN: 0742-0528</identifier><identifier>EISSN: 1525-6073</identifier><identifier>DOI: 10.3109/07420529808998668</identifier><identifier>PMID: 9493713</identifier><identifier>CODEN: CHBIE4</identifier><language>eng</language><publisher>Monticello, NY: Informa UK Ltd</publisher><subject>Activity Cycles - drug effects ; Activity Cycles - physiology ; Animals ; Aorta, Thoracic - drug effects ; Aorta, Thoracic - physiology ; Biological and medical sciences ; Blood vessels and receptors ; Fundamental and applied biological sciences. Psychology ; Male ; Muscle Contraction - drug effects ; Phenylephrine - antagonists & inhibitors ; Phenylephrine - pharmacology ; Potassium Chloride - pharmacology ; Prazosin - pharmacology ; Rat aorta ; Rats ; Rats, Wistar ; Ultradian rhythm ; Vasoactive agents ; Vasoconstrictor Agents - pharmacology ; Vertebrates: cardiovascular system</subject><ispartof>Chronobiology international, 1998, Vol.15 (1), p.39-48</ispartof><rights>1998 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1998</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-d651141c86b9a280c9c93700569414f6cc53bbceb61e512f8f1f922e7d645f3</citedby><cites>FETCH-LOGICAL-c430t-d651141c86b9a280c9c93700569414f6cc53bbceb61e512f8f1f922e7d645f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/07420529808998668$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/07420529808998668$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,777,781,4010,27904,27905,27906,59626,60415,61200,61381</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2160208$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9493713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Görgün, Cem Z.</creatorcontrib><creatorcontrib>Keskil, Zuhal Aktuna</creatorcontrib><creatorcontrib>Hodoglugil, UgUr</creatorcontrib><creatorcontrib>Ercan, Z. Sevim</creatorcontrib><creatorcontrib>Abaciog'lu, Nurettin</creatorcontrib><creatorcontrib>Zengil, Hakan</creatorcontrib><title>In Vitro Evidence of Tissue Susceptibility Rhythms. I. Temporal Variation in Effect of Potassium Chloride and Phenylephrine on Rat Aorta</title><title>Chronobiology international</title><addtitle>Chronobiol Int</addtitle><description>In this study, time-dependent variations in the in vitro sensitivity of rat thoracic aorta rings to potassium chloride (KC1) and phenylephrine (Phe) were investigated. Animals were synchronized with a 12h light and 12h darkness (lights on 08:00-20:00) schedule, and thoracic aortas were obtained at six different times of the day (1, 5, 9, 13, 17, and 21 hours after lights on). In order to avoid endothelial influence, all experiments were performed in endothelium-denuded preparations. Responses to KC1 showed time-dependent variations in all the concentrations used. Phe-induced contractions also exhibited time-dependent differences. The rhythmic pattern of Phe responses did not change with the presence of the ar adrenergic antagonist prazosin. In addition, both the ECio values of KC1 and Phe, and also the ATB values of prazosin, displayed rhythmicity. In conclusion, time of obtaining tissues is an important factor for experimental standardization in, at least, vascular smooth muscle preparations. (Chornobio Interna-tional, 15(1)39-48, 1998)</description><subject>Activity Cycles - drug effects</subject><subject>Activity Cycles - physiology</subject><subject>Animals</subject><subject>Aorta, Thoracic - drug effects</subject><subject>Aorta, Thoracic - physiology</subject><subject>Biological and medical sciences</subject><subject>Blood vessels and receptors</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Muscle Contraction - drug effects</subject><subject>Phenylephrine - antagonists & inhibitors</subject><subject>Phenylephrine - pharmacology</subject><subject>Potassium Chloride - pharmacology</subject><subject>Prazosin - pharmacology</subject><subject>Rat aorta</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Ultradian rhythm</subject><subject>Vasoactive agents</subject><subject>Vasoconstrictor Agents - pharmacology</subject><subject>Vertebrates: cardiovascular system</subject><issn>0742-0528</issn><issn>1525-6073</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtq3DAYhUVpSadJH6CLghalO091sWWLdhOGaTsQSEiGbI0sS1hBllxJbvEb9LGrYaaBEMhKi3P5dT4APmC0phjxL6guCaoIb1DDecNY8wqscEWqgqGavgarg15kQ_MWvIvxASHUIEbPwBkvOa0xXYG_OwfvTQoebn-bXjmpoNdwb2KcFbybo1RTMp2xJi3wdljSMMY13K3hXo2TD8LCexGMSMY7aBzcaq1kOjTc-CRiNPMIN4P1IVdD4Xp4Myi3WDUNwbh8ycFbkeClD0lcgDda2Kjen95zcPd9u9_8LK6uf-w2l1eFLClKRc8qjEssG9ZxQRokucxLEKoYL3GpmZQV7TqpOoZVhYluNNacEFX3rKw0PQefj61T8L9mFVM7mrzRWuGUn2Nb80ylJiwb8dEog48xKN1OwYwiLC1G7YF9-4x9znw8lc_dqPrHxAl21j-ddBGlsDoIJ018tBHMEEGHmm9Hm3Hah1H88cH2bRJL5vg_Q1_6xdcn8UEJmwYpgmof_BxchvvChn_FCbG4</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>Görgün, Cem Z.</creator><creator>Keskil, Zuhal Aktuna</creator><creator>Hodoglugil, UgUr</creator><creator>Ercan, Z. Sevim</creator><creator>Abaciog'lu, Nurettin</creator><creator>Zengil, Hakan</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Dekker</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1998</creationdate><title>In Vitro Evidence of Tissue Susceptibility Rhythms. I. Temporal Variation in Effect of Potassium Chloride and Phenylephrine on Rat Aorta</title><author>Görgün, Cem Z. ; Keskil, Zuhal Aktuna ; Hodoglugil, UgUr ; Ercan, Z. Sevim ; Abaciog'lu, Nurettin ; Zengil, Hakan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-d651141c86b9a280c9c93700569414f6cc53bbceb61e512f8f1f922e7d645f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Activity Cycles - drug effects</topic><topic>Activity Cycles - physiology</topic><topic>Animals</topic><topic>Aorta, Thoracic - drug effects</topic><topic>Aorta, Thoracic - physiology</topic><topic>Biological and medical sciences</topic><topic>Blood vessels and receptors</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Muscle Contraction - drug effects</topic><topic>Phenylephrine - antagonists & inhibitors</topic><topic>Phenylephrine - pharmacology</topic><topic>Potassium Chloride - pharmacology</topic><topic>Prazosin - pharmacology</topic><topic>Rat aorta</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Ultradian rhythm</topic><topic>Vasoactive agents</topic><topic>Vasoconstrictor Agents - pharmacology</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Görgün, Cem Z.</creatorcontrib><creatorcontrib>Keskil, Zuhal Aktuna</creatorcontrib><creatorcontrib>Hodoglugil, UgUr</creatorcontrib><creatorcontrib>Ercan, Z. Sevim</creatorcontrib><creatorcontrib>Abaciog'lu, Nurettin</creatorcontrib><creatorcontrib>Zengil, Hakan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chronobiology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Görgün, Cem Z.</au><au>Keskil, Zuhal Aktuna</au><au>Hodoglugil, UgUr</au><au>Ercan, Z. Sevim</au><au>Abaciog'lu, Nurettin</au><au>Zengil, Hakan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vitro Evidence of Tissue Susceptibility Rhythms. I. Temporal Variation in Effect of Potassium Chloride and Phenylephrine on Rat Aorta</atitle><jtitle>Chronobiology international</jtitle><addtitle>Chronobiol Int</addtitle><date>1998</date><risdate>1998</risdate><volume>15</volume><issue>1</issue><spage>39</spage><epage>48</epage><pages>39-48</pages><issn>0742-0528</issn><eissn>1525-6073</eissn><coden>CHBIE4</coden><abstract>In this study, time-dependent variations in the in vitro sensitivity of rat thoracic aorta rings to potassium chloride (KC1) and phenylephrine (Phe) were investigated. Animals were synchronized with a 12h light and 12h darkness (lights on 08:00-20:00) schedule, and thoracic aortas were obtained at six different times of the day (1, 5, 9, 13, 17, and 21 hours after lights on). In order to avoid endothelial influence, all experiments were performed in endothelium-denuded preparations. Responses to KC1 showed time-dependent variations in all the concentrations used. Phe-induced contractions also exhibited time-dependent differences. The rhythmic pattern of Phe responses did not change with the presence of the ar adrenergic antagonist prazosin. In addition, both the ECio values of KC1 and Phe, and also the ATB values of prazosin, displayed rhythmicity. In conclusion, time of obtaining tissues is an important factor for experimental standardization in, at least, vascular smooth muscle preparations. (Chornobio Interna-tional, 15(1)39-48, 1998)</abstract><cop>Monticello, NY</cop><pub>Informa UK Ltd</pub><pmid>9493713</pmid><doi>10.3109/07420529808998668</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0742-0528 |
| ispartof | Chronobiology international, 1998, Vol.15 (1), p.39-48 |
| issn | 0742-0528 1525-6073 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79713726 |
| source | MEDLINE; Taylor & Francis:Master (3349 titles) |
| subjects | Activity Cycles - drug effects Activity Cycles - physiology Animals Aorta, Thoracic - drug effects Aorta, Thoracic - physiology Biological and medical sciences Blood vessels and receptors Fundamental and applied biological sciences. Psychology Male Muscle Contraction - drug effects Phenylephrine - antagonists & inhibitors Phenylephrine - pharmacology Potassium Chloride - pharmacology Prazosin - pharmacology Rat aorta Rats Rats, Wistar Ultradian rhythm Vasoactive agents Vasoconstrictor Agents - pharmacology Vertebrates: cardiovascular system |
| title | In Vitro Evidence of Tissue Susceptibility Rhythms. I. Temporal Variation in Effect of Potassium Chloride and Phenylephrine on Rat Aorta |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T18%3A02%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20Vitro%20Evidence%20of%20Tissue%20Susceptibility%20Rhythms.%20I.%20Temporal%20Variation%20in%20Effect%20of%20Potassium%20Chloride%20and%20Phenylephrine%20on%20Rat%20Aorta&rft.jtitle=Chronobiology%20international&rft.au=G%C3%B6rg%C3%BCn,%20Cem%20Z.&rft.date=1998&rft.volume=15&rft.issue=1&rft.spage=39&rft.epage=48&rft.pages=39-48&rft.issn=0742-0528&rft.eissn=1525-6073&rft.coden=CHBIE4&rft_id=info:doi/10.3109/07420529808998668&rft_dat=%3Cproquest_pubme%3E79713726%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79713726&rft_id=info:pmid/9493713&rfr_iscdi=true |