EFFECT OF THE QUASSINOIDS GLAUCARUBOLONE AND SIMALIKALACTONE D ON GROWTH OF CELLS PERMANENTLY INFECTED WITH FELINE AND HUMAN IMMUNODEFICIENCY VIRUSES AND ON VIRAL INFECTIONS
Growth of Crandall feline kidney cells permanently infected with feline immunodeficiency virus was inhibited by the anti-cancer quassinoid glaucarubolone whereas growth of uninfected cells was not inhibited. Similar results were obtained for human MOLT-4 cells infected with HIV-1. The results sugges...
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| Veröffentlicht in: | Life sciences (1973) 1997-12, Vol.62 (3), p.213-219 |
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| container_title | Life sciences (1973) |
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| creator | Morré, D.James Zeichhardt, Heinz Maxeiner, Hans-Günther Grünert, Hans-Peter Sawitzky, Dirk Grieco, Paul |
| description | Growth of Crandall feline kidney cells permanently infected with feline immunodeficiency virus was inhibited by the anti-cancer quassinoid glaucarubolone whereas growth of uninfected cells was not inhibited. Similar results were obtained for human MOLT-4 cells infected with HIV-1. The results suggest that cell lines permanently infected with either the feline or the human lentivirus exhibit growth response characteristics to the quassinoids in common with other cell lines malignantly transformed. In addition the quassinoids may delay viral infection suggesting some commonality between the mechanism responsible for inhibition of the growth of the transformed phenotype and viral infection. |
| doi_str_mv | 10.1016/S0024-3205(97)01089-8 |
| format | Article |
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Similar results were obtained for human MOLT-4 cells infected with HIV-1. The results suggest that cell lines permanently infected with either the feline or the human lentivirus exhibit growth response characteristics to the quassinoids in common with other cell lines malignantly transformed. In addition the quassinoids may delay viral infection suggesting some commonality between the mechanism responsible for inhibition of the growth of the transformed phenotype and viral infection.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/S0024-3205(97)01089-8</identifier><identifier>PMID: 9488099</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>AIDS/HIV ; Animals ; Antineoplastic Agents, Phytogenic - pharmacology ; antiviral ; Cats ; Cell Division - drug effects ; Cell Transformation, Viral - drug effects ; feline immunodeficiency virus ; Glaucarubin - analogs & derivatives ; Glaucarubin - pharmacology ; glaucarubolone ; HIV-1 ; HIV-1 - drug effects ; Humans ; Immunodeficiency Virus, Feline - drug effects ; NADH oxidase ; quassinoids ; Quassins ; simalikalactone D</subject><ispartof>Life sciences (1973), 1997-12, Vol.62 (3), p.213-219</ispartof><rights>1997 Elsevier Science Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-42fa6a45591f4f3cdc5f8c461b21632ef9ae382a1544d9ea4b933923c3a0c9a63</citedby><cites>FETCH-LOGICAL-c391t-42fa6a45591f4f3cdc5f8c461b21632ef9ae382a1544d9ea4b933923c3a0c9a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0024-3205(97)01089-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9488099$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morré, D.James</creatorcontrib><creatorcontrib>Zeichhardt, Heinz</creatorcontrib><creatorcontrib>Maxeiner, Hans-Günther</creatorcontrib><creatorcontrib>Grünert, Hans-Peter</creatorcontrib><creatorcontrib>Sawitzky, Dirk</creatorcontrib><creatorcontrib>Grieco, Paul</creatorcontrib><title>EFFECT OF THE QUASSINOIDS GLAUCARUBOLONE AND SIMALIKALACTONE D ON GROWTH OF CELLS PERMANENTLY INFECTED WITH FELINE AND HUMAN IMMUNODEFICIENCY VIRUSES AND ON VIRAL INFECTIONS</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Growth of Crandall feline kidney cells permanently infected with feline immunodeficiency virus was inhibited by the anti-cancer quassinoid glaucarubolone whereas growth of uninfected cells was not inhibited. Similar results were obtained for human MOLT-4 cells infected with HIV-1. The results suggest that cell lines permanently infected with either the feline or the human lentivirus exhibit growth response characteristics to the quassinoids in common with other cell lines malignantly transformed. In addition the quassinoids may delay viral infection suggesting some commonality between the mechanism responsible for inhibition of the growth of the transformed phenotype and viral infection.</description><subject>AIDS/HIV</subject><subject>Animals</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>antiviral</subject><subject>Cats</subject><subject>Cell Division - drug effects</subject><subject>Cell Transformation, Viral - drug effects</subject><subject>feline immunodeficiency virus</subject><subject>Glaucarubin - analogs & derivatives</subject><subject>Glaucarubin - pharmacology</subject><subject>glaucarubolone</subject><subject>HIV-1</subject><subject>HIV-1 - drug effects</subject><subject>Humans</subject><subject>Immunodeficiency Virus, Feline - drug effects</subject><subject>NADH oxidase</subject><subject>quassinoids</subject><subject>Quassins</subject><subject>simalikalactone D</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd1u0zAYhiMEGmVwCZN8hOAgYMf5sY-QSZzWwnWgSZh2ZLmOIwW160jaSbso7pGkjXa6I8v-nu95Jb-ed4PgFwRR_LWEMAh9HMDoE00-QwQJ9ckrb4FIQn0YY_TaWzwjb713w_AHQhhFCb7yrmhICKR04f3jec7TChQ5qFYc_KpZWQpViKwES8nqlG3q74UsFAdMZaAUaybFDyZZWk1vGSgUWG6K22o1GVIuZQl-8s2aKa4qeQeEmuw8A7diRHIuxWxa1SMDxHpdqyLjuUgFV-kd-C02dcnLMzKqxyuTs0QUqnzvvWnNbnAf5vPaq3NepStfFkuRMulbTNHRD4PWxCaMIorasMW2sVFLbBijbYBiHLiWGodJYFAUhg11JtxSjGmALTbQUhPja-_jxfvQH_6e3HDU-26wbrcz9-5wGnRCE4QheRmc4kJMyAhGF9D2h2HoXasf-m5v-ieNoJ761Oc-9VSWpok-96mnvZs54LTdu-Z5ay5wnH-7zN34HY-d6_VgO3dvXdP1zh51c-heSPgP78ShnA</recordid><startdate>19971212</startdate><enddate>19971212</enddate><creator>Morré, D.James</creator><creator>Zeichhardt, Heinz</creator><creator>Maxeiner, Hans-Günther</creator><creator>Grünert, Hans-Peter</creator><creator>Sawitzky, Dirk</creator><creator>Grieco, Paul</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19971212</creationdate><title>EFFECT OF THE QUASSINOIDS GLAUCARUBOLONE AND SIMALIKALACTONE D ON GROWTH OF CELLS PERMANENTLY INFECTED WITH FELINE AND HUMAN IMMUNODEFICIENCY VIRUSES AND ON VIRAL INFECTIONS</title><author>Morré, D.James ; Zeichhardt, Heinz ; Maxeiner, Hans-Günther ; Grünert, Hans-Peter ; Sawitzky, Dirk ; Grieco, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-42fa6a45591f4f3cdc5f8c461b21632ef9ae382a1544d9ea4b933923c3a0c9a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>AIDS/HIV</topic><topic>Animals</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>antiviral</topic><topic>Cats</topic><topic>Cell Division - drug effects</topic><topic>Cell Transformation, Viral - drug effects</topic><topic>feline immunodeficiency virus</topic><topic>Glaucarubin - analogs & derivatives</topic><topic>Glaucarubin - pharmacology</topic><topic>glaucarubolone</topic><topic>HIV-1</topic><topic>HIV-1 - drug effects</topic><topic>Humans</topic><topic>Immunodeficiency Virus, Feline - drug effects</topic><topic>NADH oxidase</topic><topic>quassinoids</topic><topic>Quassins</topic><topic>simalikalactone D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morré, D.James</creatorcontrib><creatorcontrib>Zeichhardt, Heinz</creatorcontrib><creatorcontrib>Maxeiner, Hans-Günther</creatorcontrib><creatorcontrib>Grünert, Hans-Peter</creatorcontrib><creatorcontrib>Sawitzky, Dirk</creatorcontrib><creatorcontrib>Grieco, Paul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morré, D.James</au><au>Zeichhardt, Heinz</au><au>Maxeiner, Hans-Günther</au><au>Grünert, Hans-Peter</au><au>Sawitzky, Dirk</au><au>Grieco, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECT OF THE QUASSINOIDS GLAUCARUBOLONE AND SIMALIKALACTONE D ON GROWTH OF CELLS PERMANENTLY INFECTED WITH FELINE AND HUMAN IMMUNODEFICIENCY VIRUSES AND ON VIRAL INFECTIONS</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1997-12-12</date><risdate>1997</risdate><volume>62</volume><issue>3</issue><spage>213</spage><epage>219</epage><pages>213-219</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Growth of Crandall feline kidney cells permanently infected with feline immunodeficiency virus was inhibited by the anti-cancer quassinoid glaucarubolone whereas growth of uninfected cells was not inhibited. Similar results were obtained for human MOLT-4 cells infected with HIV-1. The results suggest that cell lines permanently infected with either the feline or the human lentivirus exhibit growth response characteristics to the quassinoids in common with other cell lines malignantly transformed. In addition the quassinoids may delay viral infection suggesting some commonality between the mechanism responsible for inhibition of the growth of the transformed phenotype and viral infection.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>9488099</pmid><doi>10.1016/S0024-3205(97)01089-8</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 1997-12, Vol.62 (3), p.213-219 |
| issn | 0024-3205 1879-0631 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | AIDS/HIV Animals Antineoplastic Agents, Phytogenic - pharmacology antiviral Cats Cell Division - drug effects Cell Transformation, Viral - drug effects feline immunodeficiency virus Glaucarubin - analogs & derivatives Glaucarubin - pharmacology glaucarubolone HIV-1 HIV-1 - drug effects Humans Immunodeficiency Virus, Feline - drug effects NADH oxidase quassinoids Quassins simalikalactone D |
| title | EFFECT OF THE QUASSINOIDS GLAUCARUBOLONE AND SIMALIKALACTONE D ON GROWTH OF CELLS PERMANENTLY INFECTED WITH FELINE AND HUMAN IMMUNODEFICIENCY VIRUSES AND ON VIRAL INFECTIONS |
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