Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat : a candidate for schizophrenia and bipolar disorder?

Many human hereditary neurodegenerative diseases are caused by expanded CAG repeats, and anonymous CAG expansions have also been described in schizophrenia and bipolar disorder. We have isolated and sequenced a novel human cDNA encoding a neuronal, small conductance calcium-activated potassium chann...

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Veröffentlicht in:	Molecular psychiatry 1998, Vol.3 (1), p.32-37
Hauptverfasser:	CHANDY, K. G, FANTINO, E, MORRIS-ROSENDAHL, D. J, GARGUS, J. J, WITTEKINDT, O, KALMAN, K, TONG, L.-L, HO, T.-H, GUTMAN, G. A, CROCQ, M.-A, GANGULI, R, NIMGAONKAR, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Alleles Amino Acid Sequence Biological and medical sciences Bipolar disorder Bipolar Disorder - genetics Brain - metabolism Calcium channels Calcium conductance Environmental effects Excitability Firing pattern Gene frequency Humans Medical sciences Mental disorders Molecular Sequence Data Neurodegenerative diseases Neurons - metabolism Neuropeptides - biosynthesis Neuropeptides - chemistry Neuropeptides - genetics Polyglutamine Polymorphism, Genetic Potassium Potassium channels (calcium-gated) Potassium Channels - biosynthesis Potassium Channels - chemistry Potassium Channels - genetics Potassium conductance Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - genetics Sequence Alignment Sequence Homology, Amino Acid Small-Conductance Calcium-Activated Potassium Channels Trinucleotide repeat diseases Trinucleotide Repeats
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