Cloning, purification and characterization of DNA polymerase beta from Xenopus laevis--studies on its potential role in DNA-end joining

Double-strand breaks in the DNA of vertebrate cells are joined by mechanisms of non-homologous DNA-end joining (NEJ). In extracts from Xenopus eggs, NEJ is inhibited by dideoxynucleotides, indicating a possible involvement of DNA polymerase beta (Pol beta). Since some types of NEJ products were show...

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Veröffentlicht in:	European journal of biochemistry 1998-01, Vol.251 (1-2), p.81-90
Hauptverfasser:	Reichenberger, S, Pfeiffer, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cloning, Molecular DNA - metabolism DNA Polymerase beta - genetics DNA Polymerase beta - isolation & purification DNA Polymerase beta - metabolism Escherichia coli Freshwater Humans Molecular Sequence Data oligonucleotides Rats Recombinant Proteins - genetics Recombinant Proteins - metabolism Sequence Homology, Amino Acid Xenopus laevis
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