Exposure to inescapable but not escapable shock increases extracellular levels of 5-HT in the dorsal raphe nucleus of the rat
The effects of escapable and yoked inescapable electric tailshocks on extracellular levels of serotonin (5-HT) in the dorsal raphe nucleus were measured by in vivo microdialysis. In comparison to either control rats or to their own preshock baseline, rats exposed to inescapable shock showed an incre...
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| Veröffentlicht in: | Brain research 1998-02, Vol.783 (1), p.115-120 |
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| creator | Maswood, Sharmin Barter, Julie E Watkins, Linda R Maier, Steven F |
| description | The effects of escapable and yoked inescapable electric tailshocks on extracellular levels of serotonin (5-HT) in the dorsal raphe nucleus were measured by in vivo microdialysis. In comparison to either control rats or to their own preshock baseline, rats exposed to inescapable shock showed an increase in extracellular 5-HT within 25 min of shock initiation, and 5-HT levels continued to rise during the remainder of the shock session. Rats that were exposed to comparable shock treatment, but that were given the opportunity to escape, did not show an increase in 5-HT. Rats that were restrained but not shocked also did not show an increase in 5-HT. These results add further support to suggestions that serotonergic changes occur in the dorsal raphe nucleus during inescapable shock and that such changes may contribute to the behavioral effects of inescapable shock. |
| doi_str_mv | 10.1016/S0006-8993(97)01313-9 |
| format | Article |
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In comparison to either control rats or to their own preshock baseline, rats exposed to inescapable shock showed an increase in extracellular 5-HT within 25 min of shock initiation, and 5-HT levels continued to rise during the remainder of the shock session. Rats that were exposed to comparable shock treatment, but that were given the opportunity to escape, did not show an increase in 5-HT. Rats that were restrained but not shocked also did not show an increase in 5-HT. These results add further support to suggestions that serotonergic changes occur in the dorsal raphe nucleus during inescapable shock and that such changes may contribute to the behavioral effects of inescapable shock.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(97)01313-9</identifier><identifier>PMID: 9479059</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>5-HIAA ; 5-HT ; Animals ; Avoidance Learning - physiology ; Behavioral psychophysiology ; Biological and medical sciences ; Dorsal raphe nucleus ; Electroshock ; Fundamental and applied biological sciences. Psychology ; Hydroxyindoleacetic Acid - metabolism ; In vivo microdialysis ; Inescapable shock ; Learned helplessness ; Male ; Microdialysis ; Neurotransmission and behavior ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Raphe Nuclei - metabolism ; Rats ; Rats, Sprague-Dawley ; Serotonin - metabolism</subject><ispartof>Brain research, 1998-02, Vol.783 (1), p.115-120</ispartof><rights>1998 Elsevier Science B.V.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-22c06d70c204cbbc1aa19012da44f2c1faf4c590ef1afe0893207d5d0d2ba6f33</citedby><cites>FETCH-LOGICAL-c472t-22c06d70c204cbbc1aa19012da44f2c1faf4c590ef1afe0893207d5d0d2ba6f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006899397013139$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2176254$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9479059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maswood, Sharmin</creatorcontrib><creatorcontrib>Barter, Julie E</creatorcontrib><creatorcontrib>Watkins, Linda R</creatorcontrib><creatorcontrib>Maier, Steven F</creatorcontrib><title>Exposure to inescapable but not escapable shock increases extracellular levels of 5-HT in the dorsal raphe nucleus of the rat</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The effects of escapable and yoked inescapable electric tailshocks on extracellular levels of serotonin (5-HT) in the dorsal raphe nucleus were measured by in vivo microdialysis. In comparison to either control rats or to their own preshock baseline, rats exposed to inescapable shock showed an increase in extracellular 5-HT within 25 min of shock initiation, and 5-HT levels continued to rise during the remainder of the shock session. Rats that were exposed to comparable shock treatment, but that were given the opportunity to escape, did not show an increase in 5-HT. Rats that were restrained but not shocked also did not show an increase in 5-HT. These results add further support to suggestions that serotonergic changes occur in the dorsal raphe nucleus during inescapable shock and that such changes may contribute to the behavioral effects of inescapable shock.</description><subject>5-HIAA</subject><subject>5-HT</subject><subject>Animals</subject><subject>Avoidance Learning - physiology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Dorsal raphe nucleus</subject><subject>Electroshock</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hydroxyindoleacetic Acid - metabolism</subject><subject>In vivo microdialysis</subject><subject>Inescapable shock</subject><subject>Learned helplessness</subject><subject>Male</subject><subject>Microdialysis</subject><subject>Neurotransmission and behavior</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Raphe Nuclei - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Serotonin - metabolism</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAUhS0EKkPhJ1TyAiFYBK6dh8crhKpCkSqxoKytG_taDXjiYCdVWfDfcWZGw7Ir6_p896FzGLsQ8F6A6D58B4Cu2mpdv9XqHYha1JV-wjZiq2TVyQaess0Jec5e5PyzlHWt4Yyd6UZpaPWG_b16mGJeEvE58mGkbHHCPhDvl5mPceb_f_JdtL8KYxNhpszpYU5oKYQlYOKB7ilkHj1vq-vbgvH5jriLKWPgCadSjIsNtOyZVUs4v2TPPIZMr47vOfvx-er28rq6-fbl6-Wnm8o2Ss6VlBY6p8BKaGzfW4EoNAjpsGm8tMKjb2yrgbxAT7DVtQTlWgdO9tj5uj5nbw5zpxR_L5RnsxvyejqOFJdslFZCSN0-CopOluntOrE9gDbFnBN5M6Vhh-mPEWDWfMw-H7Oab7Qy-3yMLn0XxwVLvyN36joGUvTXRx2L8cEnHO2QT5gUqpNtU7CPB6x4TvcDJZPtQKMlNySys3FxeOSQf81Ercw</recordid><startdate>19980202</startdate><enddate>19980202</enddate><creator>Maswood, Sharmin</creator><creator>Barter, Julie E</creator><creator>Watkins, Linda R</creator><creator>Maier, Steven F</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19980202</creationdate><title>Exposure to inescapable but not escapable shock increases extracellular levels of 5-HT in the dorsal raphe nucleus of the rat</title><author>Maswood, Sharmin ; Barter, Julie E ; Watkins, Linda R ; Maier, Steven F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-22c06d70c204cbbc1aa19012da44f2c1faf4c590ef1afe0893207d5d0d2ba6f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>5-HIAA</topic><topic>5-HT</topic><topic>Animals</topic><topic>Avoidance Learning - physiology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Dorsal raphe nucleus</topic><topic>Electroshock</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hydroxyindoleacetic Acid - metabolism</topic><topic>In vivo microdialysis</topic><topic>Inescapable shock</topic><topic>Learned helplessness</topic><topic>Male</topic><topic>Microdialysis</topic><topic>Neurotransmission and behavior</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Raphe Nuclei - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Serotonin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maswood, Sharmin</creatorcontrib><creatorcontrib>Barter, Julie E</creatorcontrib><creatorcontrib>Watkins, Linda R</creatorcontrib><creatorcontrib>Maier, Steven F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maswood, Sharmin</au><au>Barter, Julie E</au><au>Watkins, Linda R</au><au>Maier, Steven F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exposure to inescapable but not escapable shock increases extracellular levels of 5-HT in the dorsal raphe nucleus of the rat</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1998-02-02</date><risdate>1998</risdate><volume>783</volume><issue>1</issue><spage>115</spage><epage>120</epage><pages>115-120</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The effects of escapable and yoked inescapable electric tailshocks on extracellular levels of serotonin (5-HT) in the dorsal raphe nucleus were measured by in vivo microdialysis. In comparison to either control rats or to their own preshock baseline, rats exposed to inescapable shock showed an increase in extracellular 5-HT within 25 min of shock initiation, and 5-HT levels continued to rise during the remainder of the shock session. Rats that were exposed to comparable shock treatment, but that were given the opportunity to escape, did not show an increase in 5-HT. Rats that were restrained but not shocked also did not show an increase in 5-HT. These results add further support to suggestions that serotonergic changes occur in the dorsal raphe nucleus during inescapable shock and that such changes may contribute to the behavioral effects of inescapable shock.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>9479059</pmid><doi>10.1016/S0006-8993(97)01313-9</doi><tpages>6</tpages></addata></record> |
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| ispartof | Brain research, 1998-02, Vol.783 (1), p.115-120 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 5-HIAA 5-HT Animals Avoidance Learning - physiology Behavioral psychophysiology Biological and medical sciences Dorsal raphe nucleus Electroshock Fundamental and applied biological sciences. Psychology Hydroxyindoleacetic Acid - metabolism In vivo microdialysis Inescapable shock Learned helplessness Male Microdialysis Neurotransmission and behavior Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Raphe Nuclei - metabolism Rats Rats, Sprague-Dawley Serotonin - metabolism |
| title | Exposure to inescapable but not escapable shock increases extracellular levels of 5-HT in the dorsal raphe nucleus of the rat |
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