CHEMICAL MODIFICATION OF ERYTHROMYCINS: III. IN VITRO AND IN VIVO ANTIBACTERIAL ACTIVITIES OF NEW SEMISYNTHETIC 6-O-METHYLERYTHROMYCINS A, TE-031 (CLARITHROMYCIN) AND TE-032

The in vitro and in vivo antibacterial activities of 6-O-methylerythromycin A (TE-031, A-56268, or clarithromycin) and 6, 11-di-O-methylerythromycin A (TE-032) have been compared with those of erythromycin A (EM) and josamycin (JM). TE-031 and TE-032, having the same antibacterial spectra as EM, are...

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Veröffentlicht in:	Journal of antibiotics 1990/03/25, Vol.43(3), pp.295-305
Hauptverfasser:	MORIMOTO, SHIGEO, NAGATE, TAKATOSHI, SUGITA, KAZUHIKO, ONO, TAKEO, NUMATA, KAZUO, MIYACHI, JUNKO, MISAWA, YOKO, YAMADA, KENJI, OMURA, SADAFUMI
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria - drug effects Biological and medical sciences Clarithromycin Dogs Erythromycin - analogs & derivatives Erythromycin - pharmacokinetics Erythromycin - pharmacology Erythromycin - therapeutic use Hydrogen-Ion Concentration Josamycin - pharmacokinetics Josamycin - pharmacology Josamycin - therapeutic use Male Medical sciences Mice Mice, Inbred ICR Pharmacology. Drug treatments Rabbits Rats Rats, Inbred Strains Staphylococcal Infections - drug therapy Streptococcal Infections - drug therapy
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