Hepatobiliary alterations in patients with inflammatory bowel disease: a multicenter study. Caprilli & Gruppo Italiano Studio Colon-Retto
Four hundred and eighty-four patients with inflammatory bowel disease underwent clinical examination, ultrasonography, and biochemical liver function tests, to estimate the prevalence of hepatobiliary alterations. The patient group included patients without a history of liver disease. Controls were...
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| Veröffentlicht in: | Scandinavian journal of gastroenterology 1998-01, Vol.33 (1), p.93-98 |
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| container_title | Scandinavian journal of gastroenterology |
| container_volume | 33 |
| creator | Riegler, G D'Incà, R Sturniolo, G C Corrao, G Del Vecchio Blanco, C Di Leo, V Carratù, R Ingrosso, M Pelli, M A Morini, S Valpiani, D Cantarini, D Usai, P Papi, C Caprilli, R |
| description | Four hundred and eighty-four patients with inflammatory bowel disease underwent clinical examination, ultrasonography, and biochemical liver function tests, to estimate the prevalence of hepatobiliary alterations. The patient group included patients without a history of liver disease. Controls were recruited from patients with functional symptoms.
More patients with ulcerative colitis than controls had liver steatosis and increased alkaline phosphatase levels. Factors increasing the probability of liver damage were long-standing disease, the presence of moderate/severe disease activity, and treatment with steroids and mesalazine. A significant association was found between biliary disease and long-standing colitis and also therapy with steroids and mesalazine. Alkaline phosphatase and aminotransferase levels were significantly higher in Crohn's disease patients than in controls. Hepatic and biliary damage was found more commonly in the 1st year after diagnosis.
The monitoring of hepatobiliary function is suggested for patients with inflammatory bowel disease, even in the absence of symptoms and history. |
| format | Article |
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More patients with ulcerative colitis than controls had liver steatosis and increased alkaline phosphatase levels. Factors increasing the probability of liver damage were long-standing disease, the presence of moderate/severe disease activity, and treatment with steroids and mesalazine. A significant association was found between biliary disease and long-standing colitis and also therapy with steroids and mesalazine. Alkaline phosphatase and aminotransferase levels were significantly higher in Crohn's disease patients than in controls. Hepatic and biliary damage was found more commonly in the 1st year after diagnosis.
The monitoring of hepatobiliary function is suggested for patients with inflammatory bowel disease, even in the absence of symptoms and history.</description><identifier>ISSN: 0036-5521</identifier><identifier>PMID: 9489915</identifier><language>eng</language><publisher>England</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biliary Tract Diseases - etiology ; Biliary Tract Diseases - pathology ; Biliary Tract Diseases - physiopathology ; Child ; Colitis, Ulcerative - complications ; Colitis, Ulcerative - pathology ; Colitis, Ulcerative - physiopathology ; Crohn Disease - complications ; Crohn Disease - pathology ; Crohn Disease - physiopathology ; Female ; Humans ; Liver Diseases - etiology ; Liver Diseases - pathology ; Liver Diseases - physiopathology ; Male ; Middle Aged</subject><ispartof>Scandinavian journal of gastroenterology, 1998-01, Vol.33 (1), p.93-98</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9489915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Riegler, G</creatorcontrib><creatorcontrib>D'Incà, R</creatorcontrib><creatorcontrib>Sturniolo, G C</creatorcontrib><creatorcontrib>Corrao, G</creatorcontrib><creatorcontrib>Del Vecchio Blanco, C</creatorcontrib><creatorcontrib>Di Leo, V</creatorcontrib><creatorcontrib>Carratù, R</creatorcontrib><creatorcontrib>Ingrosso, M</creatorcontrib><creatorcontrib>Pelli, M A</creatorcontrib><creatorcontrib>Morini, S</creatorcontrib><creatorcontrib>Valpiani, D</creatorcontrib><creatorcontrib>Cantarini, D</creatorcontrib><creatorcontrib>Usai, P</creatorcontrib><creatorcontrib>Papi, C</creatorcontrib><creatorcontrib>Caprilli, R</creatorcontrib><title>Hepatobiliary alterations in patients with inflammatory bowel disease: a multicenter study. Caprilli & Gruppo Italiano Studio Colon-Retto</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>Four hundred and eighty-four patients with inflammatory bowel disease underwent clinical examination, ultrasonography, and biochemical liver function tests, to estimate the prevalence of hepatobiliary alterations. The patient group included patients without a history of liver disease. Controls were recruited from patients with functional symptoms.
More patients with ulcerative colitis than controls had liver steatosis and increased alkaline phosphatase levels. Factors increasing the probability of liver damage were long-standing disease, the presence of moderate/severe disease activity, and treatment with steroids and mesalazine. A significant association was found between biliary disease and long-standing colitis and also therapy with steroids and mesalazine. Alkaline phosphatase and aminotransferase levels were significantly higher in Crohn's disease patients than in controls. Hepatic and biliary damage was found more commonly in the 1st year after diagnosis.
The monitoring of hepatobiliary function is suggested for patients with inflammatory bowel disease, even in the absence of symptoms and history.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biliary Tract Diseases - etiology</subject><subject>Biliary Tract Diseases - pathology</subject><subject>Biliary Tract Diseases - physiopathology</subject><subject>Child</subject><subject>Colitis, Ulcerative - complications</subject><subject>Colitis, Ulcerative - pathology</subject><subject>Colitis, Ulcerative - physiopathology</subject><subject>Crohn Disease - complications</subject><subject>Crohn Disease - pathology</subject><subject>Crohn Disease - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Liver Diseases - etiology</subject><subject>Liver Diseases - pathology</subject><subject>Liver Diseases - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><issn>0036-5521</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNot0MFqwzAMBuAcNrqu2yMMdOotw0nsOt5thK0tFAZb70FOFObhxFnsUPoIe-sZ2pNA-pDQf5MsGSs2qRB5dpfce__DGBOSq0WyULxUKhPL5G9HIwanjTU4nQFtoAmDcYMHM0AcGRqCh5MJ37HRWez7yKPU7kQWWuMJPb0AQj_bYJqoaQIf5vb8DBWOk7HWwBq20zyODvYB46HBwVcUxkHlrBvSTwrBPSS3HVpPj9e6So7vb8dqlx4-tvvq9ZCOohApZ4JjqbGTnDUNKi1k2xW8UZnMeY66ISk3BS_z-GoXXbvJS1bmupPElEZdrJL1Ze04ud-ZfKh74xuyFgdys6-lkhmTvIzw6Qpn3VNbx1f6GFF9ja74B7NibIk</recordid><startdate>199801</startdate><enddate>199801</enddate><creator>Riegler, G</creator><creator>D'Incà, R</creator><creator>Sturniolo, G C</creator><creator>Corrao, G</creator><creator>Del Vecchio Blanco, C</creator><creator>Di Leo, V</creator><creator>Carratù, R</creator><creator>Ingrosso, M</creator><creator>Pelli, M A</creator><creator>Morini, S</creator><creator>Valpiani, D</creator><creator>Cantarini, D</creator><creator>Usai, P</creator><creator>Papi, C</creator><creator>Caprilli, R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199801</creationdate><title>Hepatobiliary alterations in patients with inflammatory bowel disease: a multicenter study. Caprilli & Gruppo Italiano Studio Colon-Retto</title><author>Riegler, G ; D'Incà, R ; Sturniolo, G C ; Corrao, G ; Del Vecchio Blanco, C ; Di Leo, V ; Carratù, R ; Ingrosso, M ; Pelli, M A ; Morini, S ; Valpiani, D ; Cantarini, D ; Usai, P ; Papi, C ; Caprilli, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p535-4054a8baf740cca9b57df34c917242abce7763482005f8bad628082bf7e09bab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biliary Tract Diseases - etiology</topic><topic>Biliary Tract Diseases - pathology</topic><topic>Biliary Tract Diseases - physiopathology</topic><topic>Child</topic><topic>Colitis, Ulcerative - complications</topic><topic>Colitis, Ulcerative - pathology</topic><topic>Colitis, Ulcerative - physiopathology</topic><topic>Crohn Disease - complications</topic><topic>Crohn Disease - pathology</topic><topic>Crohn Disease - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Liver Diseases - etiology</topic><topic>Liver Diseases - pathology</topic><topic>Liver Diseases - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Riegler, G</creatorcontrib><creatorcontrib>D'Incà, R</creatorcontrib><creatorcontrib>Sturniolo, G C</creatorcontrib><creatorcontrib>Corrao, G</creatorcontrib><creatorcontrib>Del Vecchio Blanco, C</creatorcontrib><creatorcontrib>Di Leo, V</creatorcontrib><creatorcontrib>Carratù, R</creatorcontrib><creatorcontrib>Ingrosso, M</creatorcontrib><creatorcontrib>Pelli, M A</creatorcontrib><creatorcontrib>Morini, S</creatorcontrib><creatorcontrib>Valpiani, D</creatorcontrib><creatorcontrib>Cantarini, D</creatorcontrib><creatorcontrib>Usai, P</creatorcontrib><creatorcontrib>Papi, C</creatorcontrib><creatorcontrib>Caprilli, R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Riegler, G</au><au>D'Incà, R</au><au>Sturniolo, G C</au><au>Corrao, G</au><au>Del Vecchio Blanco, C</au><au>Di Leo, V</au><au>Carratù, R</au><au>Ingrosso, M</au><au>Pelli, M A</au><au>Morini, S</au><au>Valpiani, D</au><au>Cantarini, D</au><au>Usai, P</au><au>Papi, C</au><au>Caprilli, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatobiliary alterations in patients with inflammatory bowel disease: a multicenter study. Caprilli & Gruppo Italiano Studio Colon-Retto</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>1998-01</date><risdate>1998</risdate><volume>33</volume><issue>1</issue><spage>93</spage><epage>98</epage><pages>93-98</pages><issn>0036-5521</issn><abstract>Four hundred and eighty-four patients with inflammatory bowel disease underwent clinical examination, ultrasonography, and biochemical liver function tests, to estimate the prevalence of hepatobiliary alterations. The patient group included patients without a history of liver disease. Controls were recruited from patients with functional symptoms.
More patients with ulcerative colitis than controls had liver steatosis and increased alkaline phosphatase levels. Factors increasing the probability of liver damage were long-standing disease, the presence of moderate/severe disease activity, and treatment with steroids and mesalazine. A significant association was found between biliary disease and long-standing colitis and also therapy with steroids and mesalazine. Alkaline phosphatase and aminotransferase levels were significantly higher in Crohn's disease patients than in controls. Hepatic and biliary damage was found more commonly in the 1st year after diagnosis.
The monitoring of hepatobiliary function is suggested for patients with inflammatory bowel disease, even in the absence of symptoms and history.</abstract><cop>England</cop><pmid>9489915</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Scandinavian journal of gastroenterology, 1998-01, Vol.33 (1), p.93-98 |
| issn | 0036-5521 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adolescent Adult Aged Aged, 80 and over Biliary Tract Diseases - etiology Biliary Tract Diseases - pathology Biliary Tract Diseases - physiopathology Child Colitis, Ulcerative - complications Colitis, Ulcerative - pathology Colitis, Ulcerative - physiopathology Crohn Disease - complications Crohn Disease - pathology Crohn Disease - physiopathology Female Humans Liver Diseases - etiology Liver Diseases - pathology Liver Diseases - physiopathology Male Middle Aged |
| title | Hepatobiliary alterations in patients with inflammatory bowel disease: a multicenter study. Caprilli & Gruppo Italiano Studio Colon-Retto |
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