Adenosine inhibits lipopolysaccharide-induced secretion of tumor necrosis factor-α in the failing human heart

The proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) has been implicated in the pathogenesis of congestive heart failure. Recent studies have shown that adenosine inhibits lipopolysaccharide (LPS)-induced expression of TNF-alpha in macrophages and rat cardiomyocytes. The aim of this...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1998-02, Vol.97 (6), p.521-524
Hauptverfasser:	WAGNER, D. R, MCTIERNAN, C, SANDERS, V. J, FELDMAN, A. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - pharmacology Adult Analysis of Variance Biological and medical sciences Cardiology. Vascular system Cardiovascular Agents - pharmacology Enzyme-Linked Immunosorbent Assay Escherichia coli Heart Heart Failure - drug therapy Heart Failure - metabolism Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans In Vitro Techniques Lipopolysaccharides - pharmacology Male Medical sciences Middle Aged Tubercidin - analogs & derivatives Tubercidin - pharmacology Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism
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