Cytotoxicity and intracellular biotransformation of N-benzyladriamycin-14-valerate (AD 198) are modulated by changes in 14-O-acyl chain length

N-benzyladriamycin-14-valerate (AD 198) is pharmacologically superior to Adriamycin (ADR) based upon comparable cytotoxicity, decreased cardiotoxicity and the ability of AD 198 to circumvent multidrug resistance conferred by either P-glycoprotein overexpression or reduced topoisomerase II activity....

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Veröffentlicht in:	Anti-cancer drugs 1998-01, Vol.9 (1), p.58-66
Hauptverfasser:	Lothstein, L, Rodrigues, P J, Sweatman, T W, Israel, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - metabolism Antibiotics, Antineoplastic - pharmacology Cell Line - drug effects Doxorubicin - analogs & derivatives Doxorubicin - metabolism Doxorubicin - pharmacology Macrophages - drug effects Macrophages - metabolism Mice Structure-Activity Relationship
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