Pedigree analysis of French Canadian families with T14484C Leber's hereditary optic neuropathy

We analyzed the clinical phenotype and determined the recurrence risks to relatives of patients with T14484C Leber's hereditary optic neuropathy (LHON). LHON is a maternally inherited optic neuropathy that primarily affects adolescent males. It is usually associated with one of three mtDNA muta...

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Veröffentlicht in:	Neurology 1998-02, Vol.50 (2), p.417-422
Hauptverfasser:	MACMILLAN, C, KIRKHAM, T, ZACKON, D, SHOUBRIDGE, E. A, FU, K, ALLISON, V, ANDERMANN, E, CHITAYAT, D, FORTIER, D, GANS, M, HARE, H, QUERCIA, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age of Onset Biological and medical sciences Canada Child Diseases of visual field, optic nerve, optic chiasma and optic tracts Female France - ethnology Humans Male Medical sciences Middle Aged Ophthalmology Optic Atrophies, Hereditary - epidemiology Optic Atrophies, Hereditary - genetics Optic Atrophies, Hereditary - physiopathology Pedigree Phenotype Point Mutation Recurrence Risk Factors Sex Characteristics
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