Targeted gene deletion of Leishmania major genes encoding developmental stage‐specific leishmanolysin (GP63)

The major surface glycoprotein of Leishmania major is a zinc metalloproteinase of 63 kDa referred to as leishmanolysin or GP63, which is encoded by a family of seven genes. Targeted gene replacement was used to delete gp63 genes 1–6 encoding the highly expressed promastigote and constitutively expre...

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