DBI-1, a Novel Gene Related to the Notch Family, Modulates Mitogenic Response to Insulin-like Growth Factor 1

The insulin-like growth factor 1 (IGF-1) receptor has been found to transform fibroblast cells when overexpressed. The removal of 108 aa from the C-terminus of the IGF-1 receptor abolishes the transforming ability of the receptor without affecting its ability to induce cell growth. The availability...

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Veröffentlicht in:	Experimental cell research 1998-02, Vol.238 (2), p.359-370
Hauptverfasser:	Hoff, Henry B., Tresini, Maria, Li, Shu, Sell, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Amino Acid Sequence Animals Base Sequence Cell Line Cell Nucleus - chemistry Cloning, Molecular DEAD-box RNA Helicases DNA - biosynthesis DNA, Complementary - genetics Gene Expression Genes - genetics insulin like growth factor 1 Insulin-Like Growth Factor I - pharmacology Mice Mitogens - pharmacology Molecular Sequence Data Notch Organ Specificity Rats Receptor, IGF Type 1 - genetics Receptor, Notch2 Receptors, Cell Surface - analysis Receptors, Cell Surface - genetics RNA, Messenger - analysis Sequence Analysis, DNA Sequence Homology, Nucleic Acid transformation
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