Pharmacological characterization of melatonin binding sites in Syrian hamster hypothalamus

The radioligand [ 125I] iodomelatonin was used to study melatonin binding sites in Syrian hamster hypothalamus and hippocampus. Scatchard analysis revealed a single binding site with nanomolar affinity in hypothalamus (K d = 1.8 ± 0.3 nM, B max=75 ± 7 mol/mg protein; n = 4) and hippocampus (K d = 2....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 1990-01, Vol.175 (1), p.71-77
Hauptverfasser:	Pickering, Darryl S., Niles, Lennard P.
Format:	Artikel
Sprache:	eng
Schlagworte:	[ 125I]Iodomelatonin binding sites Animals Binding Sites Binding, Competitive Biological and medical sciences Brain Chemistry - drug effects Cricetinae Fundamental and applied biological sciences. Psychology Hormones and neuropeptides. Regulation Hydrogen-Ion Concentration Hypothalamus Hypothalamus - drug effects Hypothalamus - metabolism Hypothalamus. Hypophysis. Epiphysis. Urophysis Iodine Radioisotopes Kinetics Male Melatonin - analogs & derivatives Melatonin receptors Mesocricetus Prazosin affinity Receptors, Melatonin Receptors, Neurotransmitter - metabolism Syrian hamster Vertebrates: endocrinology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!