Differential coupling between muscarinic receptors and G-proteins in regions of the rat brain

The coupling of muscarinic receptors to G-proteins in varius regions of the rat brain was assessed by measuring carbachol-stimulated, low- K m GTPase. The inhibition of carbachol-stimulated GTPase by the M 1-selective antagonist pirenzepine was compared to the affinity of pirenzepine for various nuc...

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Veröffentlicht in:	Biochemical pharmacology 1990-04, Vol.39 (8), p.1385-1391
Hauptverfasser:	Ghodsi-Hovsepian, Shahnaz, Messer, William S., Hoss, Wayne
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Binding and carrier proteins Biological and medical sciences Brain - metabolism Carbachol - antagonists & inhibitors Carbachol - pharmacology Cerebral Cortex - metabolism Corpus Striatum - metabolism Fundamental and applied biological sciences. Psychology GTP Phosphohydrolases - antagonists & inhibitors GTP Phosphohydrolases - metabolism GTP-Binding Proteins - metabolism Hippocampus - metabolism Kinetics Male Pirenzepine - metabolism Pirenzepine - pharmacology Proteins Rats Receptors, Muscarinic - metabolism Rhombencephalon - metabolism
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