Distinct genomic copy number in mitochondria of different mammalian organs
This study shows that mitochondria in liver, kidney, heart, and brain of the mouse have a distinct mitochondrial density. It also demonstrates that the mtDNA copy number per mitochondrion is organ‐specific. A reliable method of determining mitochondrial density per organ is by stereological analysis...
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| Veröffentlicht in: | Journal of cellular physiology 1990-04, Vol.143 (1), p.160-164 |
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| container_end_page | 164 |
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| container_title | Journal of cellular physiology |
| container_volume | 143 |
| creator | Veltri, Karen L. Espiritu, Myrna Singh, Gurmit |
| description | This study shows that mitochondria in liver, kidney, heart, and brain of the mouse have a distinct mitochondrial density. It also demonstrates that the mtDNA copy number per mitochondrion is organ‐specific. A reliable method of determining mitochondrial density per organ is by stereological analysis of tissue sections while mtDNA quantitation is by the use of radiolabelled mtDNA probe. This is the first study in which a comprehensive examination of mitochondrial density and quantitation of mitochondrial genomes in mouse organs have been done. In summary the variability is not only in mitochondrial density but also in genomic copy number in mitochondria of various tissues. |
| doi_str_mv | 10.1002/jcp.1041430122 |
| format | Article |
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Psychology ; Kidney - ultrastructure ; Mice ; Mice, Inbred C57BL ; Microscopy, Electron - methods ; Mitochondria - physiology ; Mitochondria and cell respiration ; Mitochondria, Heart - physiology ; Mitochondria, Liver - physiology ; Molecular and cellular biology</subject><ispartof>Journal of cellular physiology, 1990-04, Vol.143 (1), p.160-164</ispartof><rights>Copyright © 1990 Wiley‐Liss, Inc.</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4742-8c6ac5dbe08f241d060129d7a2f989690d18b4053013a607c8b3f9e995451a553</citedby><cites>FETCH-LOGICAL-c4742-8c6ac5dbe08f241d060129d7a2f989690d18b4053013a607c8b3f9e995451a553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.1041430122$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.1041430122$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19652721$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2318903$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Veltri, Karen L.</creatorcontrib><creatorcontrib>Espiritu, Myrna</creatorcontrib><creatorcontrib>Singh, Gurmit</creatorcontrib><title>Distinct genomic copy number in mitochondria of different mammalian organs</title><title>Journal of cellular physiology</title><addtitle>J. Cell. Physiol</addtitle><description>This study shows that mitochondria in liver, kidney, heart, and brain of the mouse have a distinct mitochondrial density. It also demonstrates that the mtDNA copy number per mitochondrion is organ‐specific. A reliable method of determining mitochondrial density per organ is by stereological analysis of tissue sections while mtDNA quantitation is by the use of radiolabelled mtDNA probe. This is the first study in which a comprehensive examination of mitochondrial density and quantitation of mitochondrial genomes in mouse organs have been done. In summary the variability is not only in mitochondrial density but also in genomic copy number in mitochondria of various tissues.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - ultrastructure</subject><subject>Cell structures and functions</subject><subject>DNA, Mitochondrial - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Kidney - ultrastructure</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microscopy, Electron - methods</subject><subject>Mitochondria - physiology</subject><subject>Mitochondria and cell respiration</subject><subject>Mitochondria, Heart - physiology</subject><subject>Mitochondria, Liver - physiology</subject><subject>Molecular and cellular biology</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUlPHDEQhS2UiAzLlVskX5JbE6_t9hFNwiZEECLhaLndNhja9sTuEcy_x2hGIE45laX63quqZwAOMDrECJEfD2ZRHwwzijAhW2CGkRQNazn5BGYVwI3kDH8BO6U8IISkpHQbbBOKO4noDJz_9GXy0UzwzsYUvIEmLVYwLkNvM_QRBj8lc5_ikL2GycHBO2ezjRMMOgQ9eh1hync6lj3w2emx2P1N3QV_jn_dzE-bi98nZ_Oji8YwwUjTmVYbPvQWdY4wPKC2Li4HoYmTnWwlGnDXM8TrPVS3SJiup05aWc_gWHNOd8H3te8ip39LWyYVfDF2HHW0aVmUkAIxKmgFD9egyamUbJ1aZB90XimM1Gt4qoan3sOrgq8b52Uf7PCGb9Kq_W-bvi5Gjy7raHx5d5U1dUFw5eSae_KjXf1nqjqfX33YoVlr67_Y5zetzo-qFVRwdXt5oujfy2PeXl8pSV8AwGeVwQ</recordid><startdate>199004</startdate><enddate>199004</enddate><creator>Veltri, Karen L.</creator><creator>Espiritu, Myrna</creator><creator>Singh, Gurmit</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199004</creationdate><title>Distinct genomic copy number in mitochondria of different mammalian organs</title><author>Veltri, Karen L. ; Espiritu, Myrna ; Singh, Gurmit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4742-8c6ac5dbe08f241d060129d7a2f989690d18b4053013a607c8b3f9e995451a553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - ultrastructure</topic><topic>Cell structures and functions</topic><topic>DNA, Mitochondrial - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Kidney - ultrastructure</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microscopy, Electron - methods</topic><topic>Mitochondria - physiology</topic><topic>Mitochondria and cell respiration</topic><topic>Mitochondria, Heart - physiology</topic><topic>Mitochondria, Liver - physiology</topic><topic>Molecular and cellular biology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Veltri, Karen L.</creatorcontrib><creatorcontrib>Espiritu, Myrna</creatorcontrib><creatorcontrib>Singh, Gurmit</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Veltri, Karen L.</au><au>Espiritu, Myrna</au><au>Singh, Gurmit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distinct genomic copy number in mitochondria of different mammalian organs</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J. 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| ispartof | Journal of cellular physiology, 1990-04, Vol.143 (1), p.160-164 |
| issn | 0021-9541 1097-4652 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Biological and medical sciences Brain - ultrastructure Cell structures and functions DNA, Mitochondrial - metabolism Fundamental and applied biological sciences. Psychology Kidney - ultrastructure Mice Mice, Inbred C57BL Microscopy, Electron - methods Mitochondria - physiology Mitochondria and cell respiration Mitochondria, Heart - physiology Mitochondria, Liver - physiology Molecular and cellular biology |
| title | Distinct genomic copy number in mitochondria of different mammalian organs |
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