EGF Receptor and erbB-2 Tyrosine Kinase Domains Confer Cell Specificity for Mitogenic Signaling

The epidermal growth factor (EGF) receptor (EGFR) can efficiently couple with mitogenic signaling pathways when it is transfected into interleukin-3 (IL-3)-dependent 32D hematopoietic cells. When expression vectors for $erb$B-2, which is structurally related to EGFR, or its truncated counterpart, Δ...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1990-04, Vol.248 (4951), p.79-83
Hauptverfasser:	Di Fiore, Pier Paolo, Segatto, Oreste, Taylor, William G., Aaronson, Stuart A., Pierce, Jacalyn H.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 cells Amino acids Animals Antibodies Base Sequence Biological and medical sciences Cell Division Cell growth Cell Line Cell lines Cell physiology Cells Cells (Biology) Complementary DNA DNA - genetics DNA, Recombinant Epidermal growth factor Epidermal growth factors ErbB Receptors - genetics ErbB Receptors - physiology Fibroblasts - cytology Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Genetic aspects Genetic Vectors Genetics Growth Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Immunoblotting Interleukin-3 Medical research Mice Mitogens Molecular and cellular biology Molecular Sequence Data Molecules NIH 3T3 cells Physiological aspects Plasmids Protein tyrosine kinase Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - physiology Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - physiology Receptors Responses to growth factors, tumor promotors, other factors Sequence Homology, Nucleic Acid Signal Transduction Transduction Transduction (Genetics) Transfection
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