t(6;8), t(8;9) and t(8;13) translocations associated with stem cell myeloproliferative disorders have close or identical breakpoints in chromosome region 8p11-12

A stem-cell myeloproliferative disorder involving T- and B-cell, and myeloid lineages, is associated with three different translocations with a breakpoint in region p11-12 of chromosome 8: t(6;8)(q27;p11), t(8;9)(p11;q33), and t(8;13)(p12;q12), respectively. Using fluorescence in situ hybridization...

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Veröffentlicht in:	Oncogene 1998-02, Vol.16 (7), p.945-949
Hauptverfasser:	CHAFFANET, M, POPOVICI, C, PEBUSQUE, M.-J, LEROUX, D, JACROT, M, ADELAÏDE, J, DASTUGUE, N, GREGOIRE, M.-J, HAGEMEIJER, A, LAFAGE-POCHITALOFF, M, BIRNBAUM, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Blood cells Breakpoints Chromosome 8 Chromosome Mapping Chromosome translocations Chromosomes Chromosomes, Human, Pair 13 Chromosomes, Human, Pair 6 Chromosomes, Human, Pair 8 Chromosomes, Human, Pair 9 Cosmids Female Fibroblast growth factor receptor 1 Fluorescence in situ hybridization Gel electrophoresis Genes Hematologic and hematopoietic diseases Humans In Situ Hybridization, Fluorescence Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocytes B Male Medical sciences Middle Aged Myeloproliferative diseases Myeloproliferative Disorders - genetics Myeloproliferative Disorders - pathology Pulsed-field gel electrophoresis Receptor Protein-Tyrosine Kinases Receptor, Fibroblast Growth Factor, Type 1 Receptors, Fibroblast Growth Factor - genetics Restriction Mapping Stem cells Translocation, Genetic
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