Shear Stress Activates p60src-Ras-MAPK Signaling Pathways in Vascular Endothelial Cells

The aim of this study was to elucidate the upstream signaling mechanism that mediates the fluid shear stress activation of mitogen-activated protein kinases (MAPKs), including c-Jun NH2-terminal kinase (JNK) and extracellular signal-regulated kinases (ERKs), in vascular endothelial cells (ECs). Our...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 1998-02, Vol.18 (2), p.227-234
Hauptverfasser:	Jalali, Shila, Li, Yi-Shuan, Sotoudeh, Mohammad, Yuan, Suli, Li, Song, Chien, Shu, Shyy, John Y-J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood vessels and receptors Calcium-Calmodulin-Dependent Protein Kinases - metabolism Calcium-Calmodulin-Dependent Protein Kinases - physiology Cattle Cells, Cultured DNA-Binding Proteins Endothelium, Vascular - cytology Endothelium, Vascular - physiology ets-Domain Protein Elk-1 Fundamental and applied biological sciences. Psychology JNK Mitogen-Activated Protein Kinases Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinases Mutation Oncogene Protein pp60(v-src) - genetics Oncogene Protein pp60(v-src) - physiology Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-jun - metabolism Proto-Oncogene Proteins pp60(c-src) - genetics Proto-Oncogene Proteins pp60(c-src) - physiology ras Proteins - physiology Signal Transduction - physiology Space life sciences Stress, Mechanical Transcription Factors Vertebrates: cardiovascular system
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