Variations in the NRAMP1 Gene and Susceptibility to Tuberculosis in West Africans

Among inbred strains of mice, natural resistance to infection with several intracellular pathogens is controlled by a single dominant gene, designated Bcg (also known as Lsh/Ity ). 1 – 3 Two distinct phenotypes, Bcg s and Bcg r, are associated with susceptibility and resistance, respectively, to the...

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Veröffentlicht in:	The New England journal of medicine 1998-03, Vol.338 (10), p.640-644
Hauptverfasser:	Bellamy, Richard, Ruwende, Cyril, Corrah, Tumani, McAdam, Keith P.W.J, Whittle, Hilton C, Hill, Adrian V.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS/HIV Bacterial diseases Biological and medical sciences Carrier Proteins - genetics Case-Control Studies Cation Transport Proteins Female Gambia Genes Genetic Predisposition to Disease Genetic Variation Genotype Human bacterial diseases Humans Infectious diseases Male Medical research Medical sciences Membrane Proteins - genetics Mutation Odds Ratio Polymorphism, Genetic Population Tropical medicine Tuberculosis Tuberculosis and atypical mycobacterial infections Tuberculosis, Pulmonary - ethnology Tuberculosis, Pulmonary - genetics
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