Variations in the NRAMP1 Gene and Susceptibility to Tuberculosis in West Africans
Among inbred strains of mice, natural resistance to infection with several intracellular pathogens is controlled by a single dominant gene, designated Bcg (also known as Lsh/Ity ). 1 – 3 Two distinct phenotypes, Bcg s and Bcg r, are associated with susceptibility and resistance, respectively, to the...
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| Veröffentlicht in: | The New England journal of medicine 1998-03, Vol.338 (10), p.640-644 |
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| container_title | The New England journal of medicine |
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| creator | Bellamy, Richard Ruwende, Cyril Corrah, Tumani McAdam, Keith P.W.J Whittle, Hilton C Hill, Adrian V.S |
| description | Among inbred strains of mice, natural resistance to infection with several intracellular pathogens is controlled by a single dominant gene, designated
Bcg
(also known as
Lsh/Ity
).
1
–
3
Two distinct phenotypes, Bcg s and Bcg r,
are associated with susceptibility and resistance, respectively, to the early stage of infection with
Mycobacterium bovis
(bacille Calmette–Guérin),
3
M. avium
complex,
4
M. lepraemurium,
5
Leishmania donovani,
2
,
6
and
Salmonella typhimurium.
1
A candidate gene was isolated by positional cloning and designated the natural-resistance–associated macrophage protein 1 gene (
Nramp1
).
7
Nramp1
is expressed only in reticuloendothelial cells.
7
A single nonconservative amino acid substitution of aspartic acid . . . |
| doi_str_mv | 10.1056/NEJM199803053381002 |
| format | Article |
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Bcg
(also known as
Lsh/Ity
).
1
–
3
Two distinct phenotypes, Bcg s and Bcg r,
are associated with susceptibility and resistance, respectively, to the early stage of infection with
Mycobacterium bovis
(bacille Calmette–Guérin),
3
M. avium
complex,
4
M. lepraemurium,
5
Leishmania donovani,
2
,
6
and
Salmonella typhimurium.
1
A candidate gene was isolated by positional cloning and designated the natural-resistance–associated macrophage protein 1 gene (
Nramp1
).
7
Nramp1
is expressed only in reticuloendothelial cells.
7
A single nonconservative amino acid substitution of aspartic acid . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199803053381002</identifier><identifier>PMID: 9486992</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adult ; AIDS/HIV ; Bacterial diseases ; Biological and medical sciences ; Carrier Proteins - genetics ; Case-Control Studies ; Cation Transport Proteins ; Female ; Gambia ; Genes ; Genetic Predisposition to Disease ; Genetic Variation ; Genotype ; Human bacterial diseases ; Humans ; Infectious diseases ; Male ; Medical research ; Medical sciences ; Membrane Proteins - genetics ; Mutation ; Odds Ratio ; Polymorphism, Genetic ; Population ; Tropical medicine ; Tuberculosis ; Tuberculosis and atypical mycobacterial infections ; Tuberculosis, Pulmonary - ethnology ; Tuberculosis, Pulmonary - genetics</subject><ispartof>The New England journal of medicine, 1998-03, Vol.338 (10), p.640-644</ispartof><rights>Copyright © 1998 Massachusetts Medical Society. All rights reserved.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-455478487432b93b69c7b79acd998f163aaeb4f13bfa4d3a597836f77c1e32e23</citedby><cites>FETCH-LOGICAL-c427t-455478487432b93b69c7b79acd998f163aaeb4f13bfa4d3a597836f77c1e32e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199803053381002$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/223950290?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,2746,2747,26084,27905,27906,52363,54045,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2161670$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9486992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bellamy, Richard</creatorcontrib><creatorcontrib>Ruwende, Cyril</creatorcontrib><creatorcontrib>Corrah, Tumani</creatorcontrib><creatorcontrib>McAdam, Keith P.W.J</creatorcontrib><creatorcontrib>Whittle, Hilton C</creatorcontrib><creatorcontrib>Hill, Adrian V.S</creatorcontrib><title>Variations in the NRAMP1 Gene and Susceptibility to Tuberculosis in West Africans</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Among inbred strains of mice, natural resistance to infection with several intracellular pathogens is controlled by a single dominant gene, designated
Bcg
(also known as
Lsh/Ity
).
1
–
3
Two distinct phenotypes, Bcg s and Bcg r,
are associated with susceptibility and resistance, respectively, to the early stage of infection with
Mycobacterium bovis
(bacille Calmette–Guérin),
3
M. avium
complex,
4
M. lepraemurium,
5
Leishmania donovani,
2
,
6
and
Salmonella typhimurium.
1
A candidate gene was isolated by positional cloning and designated the natural-resistance–associated macrophage protein 1 gene (
Nramp1
).
7
Nramp1
is expressed only in reticuloendothelial cells.
7
A single nonconservative amino acid substitution of aspartic acid . . .</description><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins - genetics</subject><subject>Case-Control Studies</subject><subject>Cation Transport Proteins</subject><subject>Female</subject><subject>Gambia</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic Variation</subject><subject>Genotype</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Membrane Proteins - genetics</subject><subject>Mutation</subject><subject>Odds Ratio</subject><subject>Polymorphism, Genetic</subject><subject>Population</subject><subject>Tropical medicine</subject><subject>Tuberculosis</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Tuberculosis, Pulmonary - ethnology</subject><subject>Tuberculosis, Pulmonary - genetics</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkUlLxDAUx4MoOi6fQIQg4kWq2ZrlOAyuuK_HkmZSzNCmY9Ie5tubcQYPIvoueeT9_m_hD8AuRscY5fzk9vTqBislEUU5pRIjRFbAAKc8YwzxVTBIPzJjQtENsBnjBKXATK2DdcUkV4oMwMOrDk53rvUROg-7dwtvH4c39xieW2-h9mP41Edjp50rXe26Gexa-NyXNpi-bqP7Ur3Z2MFhFZzRPm6DtUrX0e4s3y3wcnb6PLrIru_OL0fD68wwIrqM5TkTkknBKCkVLbkyohRKm3G6qMKcam1LVmFaVpqNqc6VkJRXQhhsKbGEboHDRd9paD_6tEHRuLRoXWtv2z4WQnHFGVb_gpgTiRiTCdz_AU7aPvh0REEIVTkiCiWILiAT2hiDrYppcI0OswKjYm5L8YstSbW3bN2XjR1_a5Y-pPrBsq6j0XUVtDcufmMEc8zFfPjRAmuaWHg7af4c-gliC55l</recordid><startdate>19980305</startdate><enddate>19980305</enddate><creator>Bellamy, Richard</creator><creator>Ruwende, Cyril</creator><creator>Corrah, Tumani</creator><creator>McAdam, Keith P.W.J</creator><creator>Whittle, Hilton C</creator><creator>Hill, Adrian V.S</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7QL</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19980305</creationdate><title>Variations in the NRAMP1 Gene and Susceptibility to Tuberculosis in West Africans</title><author>Bellamy, Richard ; Ruwende, Cyril ; Corrah, Tumani ; McAdam, Keith P.W.J ; Whittle, Hilton C ; Hill, Adrian V.S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-455478487432b93b69c7b79acd998f163aaeb4f13bfa4d3a597836f77c1e32e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins - genetics</topic><topic>Case-Control Studies</topic><topic>Cation Transport Proteins</topic><topic>Female</topic><topic>Gambia</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic Variation</topic><topic>Genotype</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Membrane Proteins - genetics</topic><topic>Mutation</topic><topic>Odds Ratio</topic><topic>Polymorphism, Genetic</topic><topic>Population</topic><topic>Tropical medicine</topic><topic>Tuberculosis</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><topic>Tuberculosis, Pulmonary - ethnology</topic><topic>Tuberculosis, Pulmonary - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bellamy, Richard</creatorcontrib><creatorcontrib>Ruwende, Cyril</creatorcontrib><creatorcontrib>Corrah, Tumani</creatorcontrib><creatorcontrib>McAdam, Keith P.W.J</creatorcontrib><creatorcontrib>Whittle, Hilton C</creatorcontrib><creatorcontrib>Hill, Adrian V.S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bellamy, Richard</au><au>Ruwende, Cyril</au><au>Corrah, Tumani</au><au>McAdam, Keith P.W.J</au><au>Whittle, Hilton C</au><au>Hill, Adrian V.S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variations in the NRAMP1 Gene and Susceptibility to Tuberculosis in West Africans</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1998-03-05</date><risdate>1998</risdate><volume>338</volume><issue>10</issue><spage>640</spage><epage>644</epage><pages>640-644</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Among inbred strains of mice, natural resistance to infection with several intracellular pathogens is controlled by a single dominant gene, designated
Bcg
(also known as
Lsh/Ity
).
1
–
3
Two distinct phenotypes, Bcg s and Bcg r,
are associated with susceptibility and resistance, respectively, to the early stage of infection with
Mycobacterium bovis
(bacille Calmette–Guérin),
3
M. avium
complex,
4
M. lepraemurium,
5
Leishmania donovani,
2
,
6
and
Salmonella typhimurium.
1
A candidate gene was isolated by positional cloning and designated the natural-resistance–associated macrophage protein 1 gene (
Nramp1
).
7
Nramp1
is expressed only in reticuloendothelial cells.
7
A single nonconservative amino acid substitution of aspartic acid . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>9486992</pmid><doi>10.1056/NEJM199803053381002</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1998-03, Vol.338 (10), p.640-644 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79696419 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Adult AIDS/HIV Bacterial diseases Biological and medical sciences Carrier Proteins - genetics Case-Control Studies Cation Transport Proteins Female Gambia Genes Genetic Predisposition to Disease Genetic Variation Genotype Human bacterial diseases Humans Infectious diseases Male Medical research Medical sciences Membrane Proteins - genetics Mutation Odds Ratio Polymorphism, Genetic Population Tropical medicine Tuberculosis Tuberculosis and atypical mycobacterial infections Tuberculosis, Pulmonary - ethnology Tuberculosis, Pulmonary - genetics |
| title | Variations in the NRAMP1 Gene and Susceptibility to Tuberculosis in West Africans |
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