Evidence for a Cholesterol Transport Pathway from Lysosomes to Endoplasmic Reticulum That Is Independent of the Plasma Membrane

We have studied the movement of low density lipoprotein (LDL)-derived cholesterol in cultured Chinese hamster ovary cells. Our hypothesis is that when LDL cholesterol is effluxed from lysosomes, the bulk of LDL cholesterol is mobilized to the plasma membrane, while another pathway delivers LDL chole...

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Veröffentlicht in:	The Journal of biological chemistry 1998-02, Vol.273 (7), p.4266-4274
Hauptverfasser:	Underwood, K W, Jacobs, N L, Howley, A, Liscum, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphotericin B - pharmacology Androstenes - pharmacology Animals Biological Transport - drug effects Biological Transport - physiology Brefeldin A Cell Membrane - physiology CHO Cells Cholesterol Esters - metabolism Cholesterol Oxidase - metabolism Cholesterol, LDL - metabolism Cricetinae Cyclopentanes - pharmacology Endoplasmic Reticulum - enzymology Enzyme Inhibitors - pharmacology Imipramine - pharmacology Lipoproteins, LDL - metabolism Lysosomes - physiology Microscopy, Fluorescence Oleic Acid - metabolism Sphingomyelin Phosphodiesterase - antagonists & inhibitors Sphingomyelin Phosphodiesterase - metabolism Sterol O-Acyltransferase - metabolism
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