Evidence for Chlamydia pneumoniae Infection in Steroid-Dependent Asthma
Chlamydia pneumoniae is an obligate intracellular respiratory pathogen capable of persistent infection. Seroepidemic studies and the results of open-label antimicrobial treatment of patients with non-steroid-dependent asthma have suggested a potential role for C. pneumoniae in asthma. To evaluate th...
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| Veröffentlicht in: | Annals of allergy, asthma, & immunology asthma, & immunology, 1998, Vol.80 (1), p.45-49 |
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| container_title | Annals of allergy, asthma, & immunology |
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| creator | Hahn, David L Bukstein, Don Luskin, Allan Zeitz, Howard |
| description | Chlamydia pneumoniae is an obligate intracellular respiratory pathogen capable of persistent infection. Seroepidemic studies and the results of open-label antimicrobial treatment of patients with non-steroid-dependent asthma have suggested a potential role for
C. pneumoniae in asthma.
To evaluate the results of antimicrobial treatment in patients with uncontrolled steroid-dependent asthma and serologic evidence suggesting
C. pneumoniae infection.
Three nonsmoking asthmatic patients (aged 13 to 65 years) whose symptoms remained poorly controlled despite daily administration of inhaled and oral steroid (10 to 40 mg/d). All met serologic criteria for current or recent
C. pneumoniae infection
After prolonged treatment (6 to 16 weeks) with clarithromycin or azithromycin all three patients were able to discontinue oral steroids. All three patients have remained well controlled with inhaled antiasthma therapy only during 3 to 24 months of postantibiotic therapy observation.
In adolescent and adult asthmatic patients,
Chlamydia pneumoniae infection may contribute to symptoms of asthma that are poorly controlled by steroids. Serologic evidence for
C. pneumoniae infection should be sought in such patients. A trial of appropriate antibiotic therapy may be helpful in those patients with high titers of anti-
C. pneumoniae IgG antibodies. |
| doi_str_mv | 10.1016/S1081-1206(10)62938-9 |
| format | Article |
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C. pneumoniae in asthma.
To evaluate the results of antimicrobial treatment in patients with uncontrolled steroid-dependent asthma and serologic evidence suggesting
C. pneumoniae infection.
Three nonsmoking asthmatic patients (aged 13 to 65 years) whose symptoms remained poorly controlled despite daily administration of inhaled and oral steroid (10 to 40 mg/d). All met serologic criteria for current or recent
C. pneumoniae infection
After prolonged treatment (6 to 16 weeks) with clarithromycin or azithromycin all three patients were able to discontinue oral steroids. All three patients have remained well controlled with inhaled antiasthma therapy only during 3 to 24 months of postantibiotic therapy observation.
In adolescent and adult asthmatic patients,
Chlamydia pneumoniae infection may contribute to symptoms of asthma that are poorly controlled by steroids. Serologic evidence for
C. pneumoniae infection should be sought in such patients. A trial of appropriate antibiotic therapy may be helpful in those patients with high titers of anti-
C. pneumoniae IgG antibodies.</description><identifier>ISSN: 1081-1206</identifier><identifier>EISSN: 1534-4436</identifier><identifier>DOI: 10.1016/S1081-1206(10)62938-9</identifier><identifier>PMID: 9475566</identifier><identifier>CODEN: ANAEA3</identifier><language>eng</language><publisher>McLean, VA: Elsevier Inc</publisher><subject>Administration, Inhalation ; Adolescent ; Aged ; Anti-Bacterial Agents - therapeutic use ; Antibodies, Bacterial - analysis ; Asthma - drug therapy ; Asthma - microbiology ; Azithromycin - therapeutic use ; Biological and medical sciences ; Chlamydia Infections - complications ; Chlamydia Infections - diagnosis ; Chlamydia Infections - drug therapy ; Chlamydophila pneumoniae - immunology ; Chronic obstructive pulmonary disease, asthma ; Clarithromycin - therapeutic use ; Female ; Glucocorticoids - administration & dosage ; Glucocorticoids - therapeutic use ; Humans ; Immunoglobulins - analysis ; Male ; Medical sciences ; Middle Aged ; Nebulizers and Vaporizers ; Pneumology</subject><ispartof>Annals of allergy, asthma, & immunology, 1998, Vol.80 (1), p.45-49</ispartof><rights>1998 American College of Allergy, Asthma & Immunology</rights><rights>1998 INIST-CNRS</rights><rights>Copyright American College of Allergy and Immunology Jan 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-4668442be8cd06cef00ce5f368b2c33f34c56d247680485f862a7754b6b134933</citedby><cites>FETCH-LOGICAL-c447t-4668442be8cd06cef00ce5f368b2c33f34c56d247680485f862a7754b6b134933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1081-1206(10)62938-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,778,782,787,788,3539,4012,4038,4039,23913,23914,25123,27906,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2149870$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9475566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hahn, David L</creatorcontrib><creatorcontrib>Bukstein, Don</creatorcontrib><creatorcontrib>Luskin, Allan</creatorcontrib><creatorcontrib>Zeitz, Howard</creatorcontrib><title>Evidence for Chlamydia pneumoniae Infection in Steroid-Dependent Asthma</title><title>Annals of allergy, asthma, & immunology</title><addtitle>Ann Allergy Asthma Immunol</addtitle><description>Chlamydia pneumoniae is an obligate intracellular respiratory pathogen capable of persistent infection. Seroepidemic studies and the results of open-label antimicrobial treatment of patients with non-steroid-dependent asthma have suggested a potential role for
C. pneumoniae in asthma.
To evaluate the results of antimicrobial treatment in patients with uncontrolled steroid-dependent asthma and serologic evidence suggesting
C. pneumoniae infection.
Three nonsmoking asthmatic patients (aged 13 to 65 years) whose symptoms remained poorly controlled despite daily administration of inhaled and oral steroid (10 to 40 mg/d). All met serologic criteria for current or recent
C. pneumoniae infection
After prolonged treatment (6 to 16 weeks) with clarithromycin or azithromycin all three patients were able to discontinue oral steroids. All three patients have remained well controlled with inhaled antiasthma therapy only during 3 to 24 months of postantibiotic therapy observation.
In adolescent and adult asthmatic patients,
Chlamydia pneumoniae infection may contribute to symptoms of asthma that are poorly controlled by steroids. Serologic evidence for
C. pneumoniae infection should be sought in such patients. A trial of appropriate antibiotic therapy may be helpful in those patients with high titers of anti-
C. pneumoniae IgG antibodies.</description><subject>Administration, Inhalation</subject><subject>Adolescent</subject><subject>Aged</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibodies, Bacterial - analysis</subject><subject>Asthma - drug therapy</subject><subject>Asthma - microbiology</subject><subject>Azithromycin - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Chlamydia Infections - complications</subject><subject>Chlamydia Infections - diagnosis</subject><subject>Chlamydia Infections - drug therapy</subject><subject>Chlamydophila pneumoniae - immunology</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Clarithromycin - therapeutic use</subject><subject>Female</subject><subject>Glucocorticoids - administration & dosage</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Humans</subject><subject>Immunoglobulins - analysis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nebulizers and Vaporizers</subject><subject>Pneumology</subject><issn>1081-1206</issn><issn>1534-4436</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS0EKm3hI1SKEEJwCPhfxs6pqpa2VKrEoXC2HGesukrsxU4q9duT7C49cOnJI89vnj3vEXLG6FdGGXy7Y1SzmnEKnxn9ArwVum5fkWPWCFlLKeD1Uv9D3pKTUh4opUyDOCJHrVRNA3BMri8fQ4_RYeVTrjb3gx2f-mCrbcR5TDFYrG6iRzeFFKsQq7sJcwp9_R23GJfBqboo0_1o35E33g4F3x_OU_L76vLX5kd9-_P6ZnNxWzsp1VRLAC0l71C7noJDT6nDxgvQHXdCeCFdAz2XCjSVuvEauFWqkR10TMhWiFPyaa-7zenPjGUyYygOh8FGTHMxqoWWa61eBBlIqphuF_DDf-BDmnNcljCccqU53z3b7CGXUykZvdnmMNr8ZBg1axxmF4dZvV6vdnGYVfzsID53I_bPUwf_l_7HQ98WZwefbXShPGOcyVYrumDnewwXax8DZlNcWFPrQ16yMX0KL3zkL_4do_s</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>Hahn, David L</creator><creator>Bukstein, Don</creator><creator>Luskin, Allan</creator><creator>Zeitz, Howard</creator><general>Elsevier Inc</general><general>American College of Allergy, Asthma, & Immunology</general><general>American College of Allergy and Immunology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1998</creationdate><title>Evidence for Chlamydia pneumoniae Infection in Steroid-Dependent Asthma</title><author>Hahn, David L ; Bukstein, Don ; Luskin, Allan ; Zeitz, Howard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-4668442be8cd06cef00ce5f368b2c33f34c56d247680485f862a7754b6b134933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Administration, Inhalation</topic><topic>Adolescent</topic><topic>Aged</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibodies, Bacterial - analysis</topic><topic>Asthma - drug therapy</topic><topic>Asthma - microbiology</topic><topic>Azithromycin - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Chlamydia Infections - complications</topic><topic>Chlamydia Infections - diagnosis</topic><topic>Chlamydia Infections - drug therapy</topic><topic>Chlamydophila pneumoniae - immunology</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Clarithromycin - therapeutic use</topic><topic>Female</topic><topic>Glucocorticoids - administration & dosage</topic><topic>Glucocorticoids - therapeutic use</topic><topic>Humans</topic><topic>Immunoglobulins - analysis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nebulizers and Vaporizers</topic><topic>Pneumology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hahn, David L</creatorcontrib><creatorcontrib>Bukstein, Don</creatorcontrib><creatorcontrib>Luskin, Allan</creatorcontrib><creatorcontrib>Zeitz, Howard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of allergy, asthma, & immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hahn, David L</au><au>Bukstein, Don</au><au>Luskin, Allan</au><au>Zeitz, Howard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for Chlamydia pneumoniae Infection in Steroid-Dependent Asthma</atitle><jtitle>Annals of allergy, asthma, & immunology</jtitle><addtitle>Ann Allergy Asthma Immunol</addtitle><date>1998</date><risdate>1998</risdate><volume>80</volume><issue>1</issue><spage>45</spage><epage>49</epage><pages>45-49</pages><issn>1081-1206</issn><eissn>1534-4436</eissn><coden>ANAEA3</coden><abstract>Chlamydia pneumoniae is an obligate intracellular respiratory pathogen capable of persistent infection. Seroepidemic studies and the results of open-label antimicrobial treatment of patients with non-steroid-dependent asthma have suggested a potential role for
C. pneumoniae in asthma.
To evaluate the results of antimicrobial treatment in patients with uncontrolled steroid-dependent asthma and serologic evidence suggesting
C. pneumoniae infection.
Three nonsmoking asthmatic patients (aged 13 to 65 years) whose symptoms remained poorly controlled despite daily administration of inhaled and oral steroid (10 to 40 mg/d). All met serologic criteria for current or recent
C. pneumoniae infection
After prolonged treatment (6 to 16 weeks) with clarithromycin or azithromycin all three patients were able to discontinue oral steroids. All three patients have remained well controlled with inhaled antiasthma therapy only during 3 to 24 months of postantibiotic therapy observation.
In adolescent and adult asthmatic patients,
Chlamydia pneumoniae infection may contribute to symptoms of asthma that are poorly controlled by steroids. Serologic evidence for
C. pneumoniae infection should be sought in such patients. A trial of appropriate antibiotic therapy may be helpful in those patients with high titers of anti-
C. pneumoniae IgG antibodies.</abstract><cop>McLean, VA</cop><pub>Elsevier Inc</pub><pmid>9475566</pmid><doi>10.1016/S1081-1206(10)62938-9</doi><tpages>5</tpages></addata></record> |
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| ispartof | Annals of allergy, asthma, & immunology, 1998, Vol.80 (1), p.45-49 |
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| subjects | Administration, Inhalation Adolescent Aged Anti-Bacterial Agents - therapeutic use Antibodies, Bacterial - analysis Asthma - drug therapy Asthma - microbiology Azithromycin - therapeutic use Biological and medical sciences Chlamydia Infections - complications Chlamydia Infections - diagnosis Chlamydia Infections - drug therapy Chlamydophila pneumoniae - immunology Chronic obstructive pulmonary disease, asthma Clarithromycin - therapeutic use Female Glucocorticoids - administration & dosage Glucocorticoids - therapeutic use Humans Immunoglobulins - analysis Male Medical sciences Middle Aged Nebulizers and Vaporizers Pneumology |
| title | Evidence for Chlamydia pneumoniae Infection in Steroid-Dependent Asthma |
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