EGL-17(FGF) expression coordinates the attraction of the migrating sex myoblasts with vulval induction in C. elegans
During the development of the egg-laying system in Caenorhabditis elegans hermaphrodites, central gonadal cells organize the alignment of the vulva with the sex myoblasts, the progenitors of the egg-laying muscles. A fibroblast growth factor [EGL-17(FGF)] and an FGF receptor [EGL-15(FGFR)] are invol...
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| Veröffentlicht in: | Development (Cambridge) 1998-03, Vol.125 (6), p.1083-1093 |
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| container_title | Development (Cambridge) |
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| creator | Burdine, R D Branda, C S Stern, M J |
| description | During the development of the egg-laying system in Caenorhabditis elegans hermaphrodites, central gonadal cells organize the alignment of the vulva with the sex myoblasts, the progenitors of the egg-laying muscles. A fibroblast growth factor [EGL-17(FGF)] and an FGF receptor [EGL-15(FGFR)] are involved in the gonadal signals that guide the migrations of the sex myoblasts. Here we show that EGL-17(FGF) can act as an instructive guidance cue to direct the sex myoblasts to their final destinations. We find that egl-17 reporter constructs are expressed in the primary vulval cell and that EGL-17(FGF) expression in this cell correlates with the precise positioning of the sex myoblasts. We postulate that EGL-17(FGF) helps to coordinate the development of a functional egg-laying system, linking vulval induction with proper sex myoblast migration. |
| doi_str_mv | 10.1242/dev.125.6.1083 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0950-1991 |
| ispartof | Development (Cambridge), 1998-03, Vol.125 (6), p.1083-1093 |
| issn | 0950-1991 1477-9129 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79690922 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Animals Caenorhabditis elegans - cytology Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Caenorhabditis elegans Proteins Cell Movement - genetics Female Gene Expression Regulation, Developmental Genes, Helminth Genes, Reporter Genitalia, Female - cytology Genitalia, Female - growth & development Green Fluorescent Proteins Growth Substances - genetics Helminth Proteins - genetics Intercellular Signaling Peptides and Proteins Luminescent Proteins - genetics Male Models, Biological Muscle Development Muscles - cytology Mutation Stem Cells - cytology Vulva - cytology Vulva - growth & development |
| title | EGL-17(FGF) expression coordinates the attraction of the migrating sex myoblasts with vulval induction in C. elegans |
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