Clomiphene citrate directly impairs endometrial receptivity in the mouse
Clomiphene citrate (CC) has known antifecundity effects in animal models. To help define the site of action of this effect, we studied the direct effect of CC on endometrial receptivity by transferring embryos to hormonally prepared prepubertal mice. Prepubertal mice were begun on one of four blinde...
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| Veröffentlicht in: | Fertility and sterility 1990-04, Vol.53 (4), p.727-731 |
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| container_title | Fertility and sterility |
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| creator | Nelson, Lawrence M. Hershlag, Avner Kurl, Rita S. Hall, Jerry L. Stillman, Robert J. |
| description | Clomiphene citrate (CC) has known antifecundity effects in animal models. To help define the site of action of this effect, we studied the direct effect of CC on endometrial receptivity by transferring embryos to hormonally prepared prepubertal mice. Prepubertal mice were begun on one of four blinded hormonal preparations consisting of two consecutive 3-day periods of daily injections: oil vehicle, oil-progesterone (P), estradiol (E2)-P, or CC-P. Blastocysts, which had not been exposed to CC, were then surgically transferred to these prepubertal recipients. Fourteen days after embryo transfer, implantations and term pregnancies were counted at necropsy. In this model, CC demonstrated no estrogen agonist effect, and had a significant adverse effect on endometrial receptivity. CC appeared to lower fecundity by a direct endometrial effect. |
| doi_str_mv | 10.1016/S0015-0282(16)53472-4 |
| format | Article |
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To help define the site of action of this effect, we studied the direct effect of CC on endometrial receptivity by transferring embryos to hormonally prepared prepubertal mice. Prepubertal mice were begun on one of four blinded hormonal preparations consisting of two consecutive 3-day periods of daily injections: oil vehicle, oil-progesterone (P), estradiol (E2)-P, or CC-P. Blastocysts, which had not been exposed to CC, were then surgically transferred to these prepubertal recipients. Fourteen days after embryo transfer, implantations and term pregnancies were counted at necropsy. In this model, CC demonstrated no estrogen agonist effect, and had a significant adverse effect on endometrial receptivity. CC appeared to lower fecundity by a direct endometrial effect.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(16)53472-4</identifier><identifier>PMID: 2318331</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Blastocyst - physiology ; Clomiphene - pharmacology ; Drug toxicity and drugs side effects treatment ; Embryo Transfer ; Endometrium - drug effects ; Endometrium - physiology ; Female ; Gonadotropins, Equine - pharmacology ; Luteinizing Hormone - pharmacology ; Medical sciences ; Mice ; Mice, Inbred Strains ; Pharmacology. Drug treatments ; Toxicity: urogenital system ; Uterus - drug effects ; Uterus - physiology</subject><ispartof>Fertility and sterility, 1990-04, Vol.53 (4), p.727-731</ispartof><rights>1990 American Society for Reproductive Medicine</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-7c2eb936f0e1ee9d16f1e59e9f87673440c9c2b94c379ad83250adaa4f5172083</citedby><cites>FETCH-LOGICAL-c436t-7c2eb936f0e1ee9d16f1e59e9f87673440c9c2b94c379ad83250adaa4f5172083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028216534724$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5099621$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2318331$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nelson, Lawrence M.</creatorcontrib><creatorcontrib>Hershlag, Avner</creatorcontrib><creatorcontrib>Kurl, Rita S.</creatorcontrib><creatorcontrib>Hall, Jerry L.</creatorcontrib><creatorcontrib>Stillman, Robert J.</creatorcontrib><title>Clomiphene citrate directly impairs endometrial receptivity in the mouse</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Clomiphene citrate (CC) has known antifecundity effects in animal models. To help define the site of action of this effect, we studied the direct effect of CC on endometrial receptivity by transferring embryos to hormonally prepared prepubertal mice. Prepubertal mice were begun on one of four blinded hormonal preparations consisting of two consecutive 3-day periods of daily injections: oil vehicle, oil-progesterone (P), estradiol (E2)-P, or CC-P. Blastocysts, which had not been exposed to CC, were then surgically transferred to these prepubertal recipients. Fourteen days after embryo transfer, implantations and term pregnancies were counted at necropsy. In this model, CC demonstrated no estrogen agonist effect, and had a significant adverse effect on endometrial receptivity. CC appeared to lower fecundity by a direct endometrial effect.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blastocyst - physiology</subject><subject>Clomiphene - pharmacology</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Embryo Transfer</subject><subject>Endometrium - drug effects</subject><subject>Endometrium - physiology</subject><subject>Female</subject><subject>Gonadotropins, Equine - pharmacology</subject><subject>Luteinizing Hormone - pharmacology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Pharmacology. Drug treatments</subject><subject>Toxicity: urogenital system</subject><subject>Uterus - drug effects</subject><subject>Uterus - physiology</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEURYMotVZ_gjALEV2M5mOSTFYiRa1QcKGuQ5p5QyPzZZIW-u-d6ZRuXYXHPe_lchC6JviBYCIePzEmPMU0p3dE3HOWSZpmJ2hKOBcpF5ydoukROUcXIfxgjAWRdIImlJGcMTJFi3nV1q5bQwOJddGbCEnhPNhY7RJXd8b5kEBTtDVE70yV9BF00W1d7PMmiWtI6nYT4BKdlaYKcHV4Z-j79eVrvkiXH2_v8-dlajMmYiothZViosRAAFRBREmAK1BlLoVkWYatsnSlMsukMkXOKMemMCYred8c52yGbse7nW9_NxCirl2wUFWmgb6HlkrkUuKsB_kIWt-G4KHUnXe18TtNsB4M6r1BPejR_bQ3qIe968MHm1UNxXHroKzPbw65CdZUpTeNdeGIcayUoAP2NGLQy9g68DpYB42F0a4uWvdPkT9ybY0I</recordid><startdate>19900401</startdate><enddate>19900401</enddate><creator>Nelson, Lawrence M.</creator><creator>Hershlag, Avner</creator><creator>Kurl, Rita S.</creator><creator>Hall, Jerry L.</creator><creator>Stillman, Robert J.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900401</creationdate><title>Clomiphene citrate directly impairs endometrial receptivity in the mouse</title><author>Nelson, Lawrence M. ; Hershlag, Avner ; Kurl, Rita S. ; Hall, Jerry L. ; Stillman, Robert J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-7c2eb936f0e1ee9d16f1e59e9f87673440c9c2b94c379ad83250adaa4f5172083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blastocyst - physiology</topic><topic>Clomiphene - pharmacology</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Embryo Transfer</topic><topic>Endometrium - drug effects</topic><topic>Endometrium - physiology</topic><topic>Female</topic><topic>Gonadotropins, Equine - pharmacology</topic><topic>Luteinizing Hormone - pharmacology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Pharmacology. Drug treatments</topic><topic>Toxicity: urogenital system</topic><topic>Uterus - drug effects</topic><topic>Uterus - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nelson, Lawrence M.</creatorcontrib><creatorcontrib>Hershlag, Avner</creatorcontrib><creatorcontrib>Kurl, Rita S.</creatorcontrib><creatorcontrib>Hall, Jerry L.</creatorcontrib><creatorcontrib>Stillman, Robert J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nelson, Lawrence M.</au><au>Hershlag, Avner</au><au>Kurl, Rita S.</au><au>Hall, Jerry L.</au><au>Stillman, Robert J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clomiphene citrate directly impairs endometrial receptivity in the mouse</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1990-04-01</date><risdate>1990</risdate><volume>53</volume><issue>4</issue><spage>727</spage><epage>731</epage><pages>727-731</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Clomiphene citrate (CC) has known antifecundity effects in animal models. 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| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Blastocyst - physiology Clomiphene - pharmacology Drug toxicity and drugs side effects treatment Embryo Transfer Endometrium - drug effects Endometrium - physiology Female Gonadotropins, Equine - pharmacology Luteinizing Hormone - pharmacology Medical sciences Mice Mice, Inbred Strains Pharmacology. Drug treatments Toxicity: urogenital system Uterus - drug effects Uterus - physiology |
| title | Clomiphene citrate directly impairs endometrial receptivity in the mouse |
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