Motor nerve conduction velocity in very preterm infants in relation to l-thyroxine supplementation
Background: Transient hypothyroxinemia is common in preterm infants and has been associated with neurodevelopmental dysfunction and slow nerve conduction velocity. It is still unknown whether l-thyroxine supplementation is required. During an l-thyroxine supplementation trial, motor nerve conduction...
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| Veröffentlicht in: | The Journal of pediatrics 1998, Vol.132 (1), p.64-69 |
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| container_title | The Journal of pediatrics |
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| creator | Smit, Bert J. Kok, Joke H. de Vries, Linda S. van Wassenaer, Aleid G. Dekker, Friedo W. Ongerboer de Visser, Bram W. |
| description | Background: Transient hypothyroxinemia is common in preterm infants and has been associated with neurodevelopmental dysfunction and slow nerve conduction velocity. It is still unknown whether
l-thyroxine supplementation is required. During an
l-thyroxine supplementation trial, motor nerve conduction velocity was measured to answer the question whether
l-thyroxine supplementation improves motor nerve conduction velocity.
Methods: Two hundred infants < 30 weeks' gestational age were enrolled in a randomized, double-blind, placebo-controlled
l-thyroxine supplementation trial.
l-Thyroxine (8 μg/kg birthweight per day) or a placebo was administered during the first 6 weeks of life. Motor nerve conduction velocity was measured in the ulnar and posterior tibial nerve shortly after birth, at 2 weeks, at 40 weeks, and at 66 weeks postmenstrual age.
Results: At 2 weeks, the ulnar motor nerve conduction velocity had improved in the
l-thyroxine group compared with the placebo group, although the difference was not statistically significant (difference between means: 0.8 msec; 95% CI: −0.13 to 1.80;
p = 0 .06). Later on, no effect of
l-thyroxine supplementation on motor nerve conduction velocity was found.
Conclusion: This study shows that in infants < 30 weeks' gestational age
l-thyroxine supplementation during the first 6 weeks of life does not clearly improve motor nerve conduction velocity. (J Pediatr 1998;132:64-9) |
| doi_str_mv | 10.1016/S0022-3476(98)70486-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79687661</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S002234769870486X</els_id><sourcerecordid>79687661</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-fdb2d45808c6e2a08115c7d66e5ef63e4bd44c191ea6e59c90124e81efd87a5c3</originalsourceid><addsrcrecordid>eNqFkMtOxCAUhonR6Hh5BJMujNFFFVpKYWXMxFuicaEm7ggDpxHTQgU6cd7eziWzdQXn_N85kA-hU4KvCCbs-g3joshLWrMLwS9rTDnLP3fQhGBR54yX5S6abJEDdBjjN8ZYUIz30b6g9VgUEzR78cmHzEGYQ6a9M4NO1rtsDq3XNi0yu7yHRdYHSBC6sW6US3HZD9CqFZx81ubpaxH8r3WQxaHvW-jApVV8jPYa1UY42ZxH6OP-7n36mD-_PjxNb59zXXKR8sbMCkMrjrlmUCjMCal0bRiDChpWAp0ZSjURBNTYElpgUlDgBBrDa1Xp8gidr_f2wf8MEJPsbNTQtsqBH6KsBeM1Y2QEqzWog48xQCP7YDsVFpJguXQrV27lUpwUXK7cys9x7nTzwDDrwGynNjLH_GyTq6hV2wTltI1brCCU4YqP2M0ag1HG3EKQUVtwGowNoJM03v7zkT_Aa5hv</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79687661</pqid></control><display><type>article</type><title>Motor nerve conduction velocity in very preterm infants in relation to l-thyroxine supplementation</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Smit, Bert J. ; Kok, Joke H. ; de Vries, Linda S. ; van Wassenaer, Aleid G. ; Dekker, Friedo W. ; Ongerboer de Visser, Bram W.</creator><creatorcontrib>Smit, Bert J. ; Kok, Joke H. ; de Vries, Linda S. ; van Wassenaer, Aleid G. ; Dekker, Friedo W. ; Ongerboer de Visser, Bram W.</creatorcontrib><description>Background: Transient hypothyroxinemia is common in preterm infants and has been associated with neurodevelopmental dysfunction and slow nerve conduction velocity. It is still unknown whether
l-thyroxine supplementation is required. During an
l-thyroxine supplementation trial, motor nerve conduction velocity was measured to answer the question whether
l-thyroxine supplementation improves motor nerve conduction velocity.
Methods: Two hundred infants < 30 weeks' gestational age were enrolled in a randomized, double-blind, placebo-controlled
l-thyroxine supplementation trial.
l-Thyroxine (8 μg/kg birthweight per day) or a placebo was administered during the first 6 weeks of life. Motor nerve conduction velocity was measured in the ulnar and posterior tibial nerve shortly after birth, at 2 weeks, at 40 weeks, and at 66 weeks postmenstrual age.
Results: At 2 weeks, the ulnar motor nerve conduction velocity had improved in the
l-thyroxine group compared with the placebo group, although the difference was not statistically significant (difference between means: 0.8 msec; 95% CI: −0.13 to 1.80;
p = 0 .06). Later on, no effect of
l-thyroxine supplementation on motor nerve conduction velocity was found.
Conclusion: This study shows that in infants < 30 weeks' gestational age
l-thyroxine supplementation during the first 6 weeks of life does not clearly improve motor nerve conduction velocity. (J Pediatr 1998;132:64-9)</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(98)70486-X</identifier><identifier>PMID: 9470002</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Double-Blind Method ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Female ; Follow-Up Studies ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Intensive care medicine ; Linear Models ; Male ; Medical sciences ; Motor Neurons - drug effects ; Neural Conduction - drug effects ; Thyroxine - administration & dosage ; Thyroxine - blood ; Thyroxine - pharmacology ; Tibial Nerve ; Ulnar Nerve</subject><ispartof>The Journal of pediatrics, 1998, Vol.132 (1), p.64-69</ispartof><rights>1998 Mosby, Inc.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-fdb2d45808c6e2a08115c7d66e5ef63e4bd44c191ea6e59c90124e81efd87a5c3</citedby><cites>FETCH-LOGICAL-c389t-fdb2d45808c6e2a08115c7d66e5ef63e4bd44c191ea6e59c90124e81efd87a5c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S002234769870486X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2146058$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9470002$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smit, Bert J.</creatorcontrib><creatorcontrib>Kok, Joke H.</creatorcontrib><creatorcontrib>de Vries, Linda S.</creatorcontrib><creatorcontrib>van Wassenaer, Aleid G.</creatorcontrib><creatorcontrib>Dekker, Friedo W.</creatorcontrib><creatorcontrib>Ongerboer de Visser, Bram W.</creatorcontrib><title>Motor nerve conduction velocity in very preterm infants in relation to l-thyroxine supplementation</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Background: Transient hypothyroxinemia is common in preterm infants and has been associated with neurodevelopmental dysfunction and slow nerve conduction velocity. It is still unknown whether
l-thyroxine supplementation is required. During an
l-thyroxine supplementation trial, motor nerve conduction velocity was measured to answer the question whether
l-thyroxine supplementation improves motor nerve conduction velocity.
Methods: Two hundred infants < 30 weeks' gestational age were enrolled in a randomized, double-blind, placebo-controlled
l-thyroxine supplementation trial.
l-Thyroxine (8 μg/kg birthweight per day) or a placebo was administered during the first 6 weeks of life. Motor nerve conduction velocity was measured in the ulnar and posterior tibial nerve shortly after birth, at 2 weeks, at 40 weeks, and at 66 weeks postmenstrual age.
Results: At 2 weeks, the ulnar motor nerve conduction velocity had improved in the
l-thyroxine group compared with the placebo group, although the difference was not statistically significant (difference between means: 0.8 msec; 95% CI: −0.13 to 1.80;
p = 0 .06). Later on, no effect of
l-thyroxine supplementation on motor nerve conduction velocity was found.
Conclusion: This study shows that in infants < 30 weeks' gestational age
l-thyroxine supplementation during the first 6 weeks of life does not clearly improve motor nerve conduction velocity. (J Pediatr 1998;132:64-9)</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Double-Blind Method</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Intensive care medicine</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Motor Neurons - drug effects</subject><subject>Neural Conduction - drug effects</subject><subject>Thyroxine - administration & dosage</subject><subject>Thyroxine - blood</subject><subject>Thyroxine - pharmacology</subject><subject>Tibial Nerve</subject><subject>Ulnar Nerve</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOxCAUhonR6Hh5BJMujNFFFVpKYWXMxFuicaEm7ggDpxHTQgU6cd7eziWzdQXn_N85kA-hU4KvCCbs-g3joshLWrMLwS9rTDnLP3fQhGBR54yX5S6abJEDdBjjN8ZYUIz30b6g9VgUEzR78cmHzEGYQ6a9M4NO1rtsDq3XNi0yu7yHRdYHSBC6sW6US3HZD9CqFZx81ubpaxH8r3WQxaHvW-jApVV8jPYa1UY42ZxH6OP-7n36mD-_PjxNb59zXXKR8sbMCkMrjrlmUCjMCal0bRiDChpWAp0ZSjURBNTYElpgUlDgBBrDa1Xp8gidr_f2wf8MEJPsbNTQtsqBH6KsBeM1Y2QEqzWog48xQCP7YDsVFpJguXQrV27lUpwUXK7cys9x7nTzwDDrwGynNjLH_GyTq6hV2wTltI1brCCU4YqP2M0ag1HG3EKQUVtwGowNoJM03v7zkT_Aa5hv</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>Smit, Bert J.</creator><creator>Kok, Joke H.</creator><creator>de Vries, Linda S.</creator><creator>van Wassenaer, Aleid G.</creator><creator>Dekker, Friedo W.</creator><creator>Ongerboer de Visser, Bram W.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1998</creationdate><title>Motor nerve conduction velocity in very preterm infants in relation to l-thyroxine supplementation</title><author>Smit, Bert J. ; Kok, Joke H. ; de Vries, Linda S. ; van Wassenaer, Aleid G. ; Dekker, Friedo W. ; Ongerboer de Visser, Bram W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-fdb2d45808c6e2a08115c7d66e5ef63e4bd44c191ea6e59c90124e81efd87a5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Double-Blind Method</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Intensive care medicine</topic><topic>Linear Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Motor Neurons - drug effects</topic><topic>Neural Conduction - drug effects</topic><topic>Thyroxine - administration & dosage</topic><topic>Thyroxine - blood</topic><topic>Thyroxine - pharmacology</topic><topic>Tibial Nerve</topic><topic>Ulnar Nerve</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smit, Bert J.</creatorcontrib><creatorcontrib>Kok, Joke H.</creatorcontrib><creatorcontrib>de Vries, Linda S.</creatorcontrib><creatorcontrib>van Wassenaer, Aleid G.</creatorcontrib><creatorcontrib>Dekker, Friedo W.</creatorcontrib><creatorcontrib>Ongerboer de Visser, Bram W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smit, Bert J.</au><au>Kok, Joke H.</au><au>de Vries, Linda S.</au><au>van Wassenaer, Aleid G.</au><au>Dekker, Friedo W.</au><au>Ongerboer de Visser, Bram W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Motor nerve conduction velocity in very preterm infants in relation to l-thyroxine supplementation</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1998</date><risdate>1998</risdate><volume>132</volume><issue>1</issue><spage>64</spage><epage>69</epage><pages>64-69</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>Background: Transient hypothyroxinemia is common in preterm infants and has been associated with neurodevelopmental dysfunction and slow nerve conduction velocity. It is still unknown whether
l-thyroxine supplementation is required. During an
l-thyroxine supplementation trial, motor nerve conduction velocity was measured to answer the question whether
l-thyroxine supplementation improves motor nerve conduction velocity.
Methods: Two hundred infants < 30 weeks' gestational age were enrolled in a randomized, double-blind, placebo-controlled
l-thyroxine supplementation trial.
l-Thyroxine (8 μg/kg birthweight per day) or a placebo was administered during the first 6 weeks of life. Motor nerve conduction velocity was measured in the ulnar and posterior tibial nerve shortly after birth, at 2 weeks, at 40 weeks, and at 66 weeks postmenstrual age.
Results: At 2 weeks, the ulnar motor nerve conduction velocity had improved in the
l-thyroxine group compared with the placebo group, although the difference was not statistically significant (difference between means: 0.8 msec; 95% CI: −0.13 to 1.80;
p = 0 .06). Later on, no effect of
l-thyroxine supplementation on motor nerve conduction velocity was found.
Conclusion: This study shows that in infants < 30 weeks' gestational age
l-thyroxine supplementation during the first 6 weeks of life does not clearly improve motor nerve conduction velocity. (J Pediatr 1998;132:64-9)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>9470002</pmid><doi>10.1016/S0022-3476(98)70486-X</doi><tpages>6</tpages></addata></record> |
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| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Double-Blind Method Emergency and intensive care: neonates and children. Prematurity. Sudden death Female Follow-Up Studies Humans Infant Infant, Newborn Infant, Premature Intensive care medicine Linear Models Male Medical sciences Motor Neurons - drug effects Neural Conduction - drug effects Thyroxine - administration & dosage Thyroxine - blood Thyroxine - pharmacology Tibial Nerve Ulnar Nerve |
| title | Motor nerve conduction velocity in very preterm infants in relation to l-thyroxine supplementation |
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