Phenytoin sodium and magnesium sulphate in the management of eclampsia
Twenty‐two patients with eclampsia were randomly allocated to receive either intravenous phenytoin sodium or intravenous magnesium sulphate. The groups were comparable. No side‐effects occurred and therapeutic levels were obtained in both groups. While none of the 11 patients managed with magnesium...
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| Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology 1990-02, Vol.97 (2), p.104-109 |
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| container_title | BJOG : an international journal of obstetrics and gynaecology |
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| creator | DOMMISSE, J. |
| description | Twenty‐two patients with eclampsia were randomly allocated to receive either intravenous phenytoin sodium or intravenous magnesium sulphate. The groups were comparable. No side‐effects occurred and therapeutic levels were obtained in both groups. While none of the 11 patients managed with magnesium sulphate had further convulsions, four of the 11 treated with phenytoin sodium did and were subsequently effectively treated with magnesium sulphate. These results suggest that phenytoin sodium is not as effective an anticonvulsant in eclampsia as is magnesium sulphate. |
| doi_str_mv | 10.1111/j.1471-0528.1990.tb01734.x |
| format | Article |
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The groups were comparable. No side‐effects occurred and therapeutic levels were obtained in both groups. While none of the 11 patients managed with magnesium sulphate had further convulsions, four of the 11 treated with phenytoin sodium did and were subsequently effectively treated with magnesium sulphate. These results suggest that phenytoin sodium is not as effective an anticonvulsant in eclampsia as is magnesium sulphate.</description><identifier>ISSN: 1470-0328</identifier><identifier>ISSN: 0306-5456</identifier><identifier>EISSN: 1471-0528</identifier><identifier>DOI: 10.1111/j.1471-0528.1990.tb01734.x</identifier><identifier>PMID: 2317464</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Dose-Response Relationship, Drug ; Drug Evaluation ; Eclampsia - drug therapy ; Female ; Humans ; Hypertension - drug therapy ; Infusions, Intravenous ; Magnesium Sulfate - administration & dosage ; Magnesium Sulfate - therapeutic use ; Phenytoin - administration & dosage ; Phenytoin - therapeutic use ; Pregnancy ; Random Allocation</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 1990-02, Vol.97 (2), p.104-109</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3984-4666a5ae77d37ea7d64b4c5e30cba6e7fa949ae287bfa5a7e150aa5d4e1b3f183</citedby><cites>FETCH-LOGICAL-c3984-4666a5ae77d37ea7d64b4c5e30cba6e7fa949ae287bfa5a7e150aa5d4e1b3f183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-0528.1990.tb01734.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-0528.1990.tb01734.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2317464$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DOMMISSE, J.</creatorcontrib><title>Phenytoin sodium and magnesium sulphate in the management of eclampsia</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>Br J Obstet Gynaecol</addtitle><description>Twenty‐two patients with eclampsia were randomly allocated to receive either intravenous phenytoin sodium or intravenous magnesium sulphate. The groups were comparable. No side‐effects occurred and therapeutic levels were obtained in both groups. While none of the 11 patients managed with magnesium sulphate had further convulsions, four of the 11 treated with phenytoin sodium did and were subsequently effectively treated with magnesium sulphate. These results suggest that phenytoin sodium is not as effective an anticonvulsant in eclampsia as is magnesium sulphate.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Evaluation</subject><subject>Eclampsia - drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - drug therapy</subject><subject>Infusions, Intravenous</subject><subject>Magnesium Sulfate - administration & dosage</subject><subject>Magnesium Sulfate - therapeutic use</subject><subject>Phenytoin - administration & dosage</subject><subject>Phenytoin - therapeutic use</subject><subject>Pregnancy</subject><subject>Random Allocation</subject><issn>1470-0328</issn><issn>0306-5456</issn><issn>1471-0528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE1Lw0AQhhdRaq3-BCF48Ja4m93sJh4ELdYPCvWg52WSTNqUfJlNsP33bmzo3bnMDO8778BDyA2jHrN1t_WYUMylgR96LIqo18WUKS683QmZHqXTv5m6lPvhObkwZkspkz7lEzLxOVNCiilZfGyw2nd1XjmmTvO-dKBKnRLWFZphM33RbKBDxxq6DVqlgjWWWHVOnTmYFFA2JodLcpZBYfBq7DPytXj-nL-6y9XL2_xx6SY8CoUrpJQQACqVcoWgUilikQTIaRKDRJVBJCJAP1RxZn0KWUABglQgi3nGQj4jt4fcpq2_ezSdLnOTYFFAhXVvtIpkqALBrfH-YEza2pgWM920eQntXjOqB4h6qwdSeiClB4h6hKh39vh6_NLHJabH05Ga1R8O-k9e4P4fyfrpfcWo4L-60IKX</recordid><startdate>199002</startdate><enddate>199002</enddate><creator>DOMMISSE, J.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199002</creationdate><title>Phenytoin sodium and magnesium sulphate in the management of eclampsia</title><author>DOMMISSE, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3984-4666a5ae77d37ea7d64b4c5e30cba6e7fa949ae287bfa5a7e150aa5d4e1b3f183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Evaluation</topic><topic>Eclampsia - drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - drug therapy</topic><topic>Infusions, Intravenous</topic><topic>Magnesium Sulfate - administration & dosage</topic><topic>Magnesium Sulfate - therapeutic use</topic><topic>Phenytoin - administration & dosage</topic><topic>Phenytoin - therapeutic use</topic><topic>Pregnancy</topic><topic>Random Allocation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DOMMISSE, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DOMMISSE, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phenytoin sodium and magnesium sulphate in the management of eclampsia</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>Br J Obstet Gynaecol</addtitle><date>1990-02</date><risdate>1990</risdate><volume>97</volume><issue>2</issue><spage>104</spage><epage>109</epage><pages>104-109</pages><issn>1470-0328</issn><issn>0306-5456</issn><eissn>1471-0528</eissn><abstract>Twenty‐two patients with eclampsia were randomly allocated to receive either intravenous phenytoin sodium or intravenous magnesium sulphate. The groups were comparable. No side‐effects occurred and therapeutic levels were obtained in both groups. While none of the 11 patients managed with magnesium sulphate had further convulsions, four of the 11 treated with phenytoin sodium did and were subsequently effectively treated with magnesium sulphate. These results suggest that phenytoin sodium is not as effective an anticonvulsant in eclampsia as is magnesium sulphate.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2317464</pmid><doi>10.1111/j.1471-0528.1990.tb01734.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | BJOG : an international journal of obstetrics and gynaecology, 1990-02, Vol.97 (2), p.104-109 |
| issn | 1470-0328 0306-5456 1471-0528 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library; Alma/SFX Local Collection |
| subjects | Adolescent Adult Dose-Response Relationship, Drug Drug Evaluation Eclampsia - drug therapy Female Humans Hypertension - drug therapy Infusions, Intravenous Magnesium Sulfate - administration & dosage Magnesium Sulfate - therapeutic use Phenytoin - administration & dosage Phenytoin - therapeutic use Pregnancy Random Allocation |
| title | Phenytoin sodium and magnesium sulphate in the management of eclampsia |
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