Apoptotic Cell Death of Cultured Cerebral Cortical Neurons Induced by Withdrawal of Astroglial Trophic Support

Peripheral neurons which depend on NGF for their survival undergo apoptosis after NGF deprivation. However, a convenientin vitromethod for assessing the programmed cell death of the central neurons has not been established, because the dependence of particular central neurons on neurotrophic factors...

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Veröffentlicht in:	Experimental neurology 1998-01, Vol.149 (1), p.51-63
Hauptverfasser:	Ohgoh, Makoto, Kimura, Manami, Ogura, Hiroo, Katayama, Kouichi, Nishizawa, Yukio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis Apoptosis - physiology Astrocytes - physiology Biological and medical sciences caspase Caspase 1 Cell Death - drug effects Cell Separation Cells, Cultured Cerebral Cortex - cytology Cerebral Cortex - physiology Coculture Techniques cortical neurons Cysteine Endopeptidases - drug effects Fundamental and applied biological sciences. Psychology in situnick translation Isolated neuron and nerve. Neuroglia Nerve Growth Factors - pharmacology Neurons - drug effects Neurons - physiology neurotrophic factors neurotrophin Rats Rats, Wistar TUNEL method Vertebrates: nervous system and sense organs
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