Visualization of NMDA Receptor-Induced Mitochondrial Calcium Accumulation in Striatal Neurons

Ca2+influx through NMDA receptor-gated channels and the subsequent rise in intracellular Ca2+concentration ([Ca2+]i) have been implicated in cytotoxic processes that lead to irreversible neuronal injury. While many studies have focused on cytosolic Ca2+homeostasis, much less is known about Ca2+fluxe...

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Veröffentlicht in:	Experimental neurology 1998-01, Vol.149 (1), p.1-12
Hauptverfasser:	Peng, Tsung-I, Jou, Mei-Jie, Sheu, Shey-Shing, Greenamyre, J.Timothy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry and metabolism Biological and medical sciences Calcium - metabolism Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology Central nervous system Corpus Striatum - cytology Corpus Striatum - drug effects Corpus Striatum - metabolism Fluorescent Dyes Fundamental and applied biological sciences. Psychology Heterocyclic Compounds, 3-Ring Ionophores - pharmacology Microscopy, Confocal Mitochondria - metabolism N-Methylaspartate - pharmacology Neurons - metabolism Osmolar Concentration Rats - embryology Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - physiology Ruthenium Red - pharmacology Vertebrates: nervous system and sense organs
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