Toxoplasma gondii-Infected Cells Are Resistant to Multiple Inducers of Apoptosis
Infection with certain intracellular pathogens, including viruses and bacteria, may induce host cell apoptosis. On the other hand, infection with some viruses inhibits apoptosis. Complex protozoan parasites, including Toxoplasma gondii and members of Plasmodium, Leishmania, and Microsporidia, are al...
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| Veröffentlicht in: | The Journal of immunology (1950) 1998-02, Vol.160 (4), p.1824-1830 |
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| container_title | The Journal of immunology (1950) |
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| creator | Nash, Paul B Purner, Matthew B Leon, Ronald P Clarke, Penelope Duke, Richard C Curiel, Tyler J |
| description | Infection with certain intracellular pathogens, including viruses and bacteria, may induce host cell apoptosis. On the other hand, infection with some viruses inhibits apoptosis. Complex protozoan parasites, including Toxoplasma gondii and members of Plasmodium, Leishmania, and Microsporidia, are also obligate intracellular pathogens, yet relatively little is known regarding their subversion of host cell functions. We now report that cells infected with T. gondii are resistant to multiple inducers of apoptosis, including Fas-dependent and Fas-independent CTL-mediated cytotoxicity, IL-2 deprivation, gamma irradiation, UV irradiation, and the calcium ionophore beauvericin. Inhibition of such a broad array of apoptosis inducers suggests that a mechanism common to many, or perhaps all, apoptotic pathways is involved. The inhibitory activity requires live intracellular parasite and ongoing protein synthesis. Despite T. gondii-mediated inhibition of DNA fragmentation, infected cells can still be lysed by CTL. |
| doi_str_mv | 10.4049/jimmunol.160.4.1824 |
| format | Article |
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On the other hand, infection with some viruses inhibits apoptosis. Complex protozoan parasites, including Toxoplasma gondii and members of Plasmodium, Leishmania, and Microsporidia, are also obligate intracellular pathogens, yet relatively little is known regarding their subversion of host cell functions. We now report that cells infected with T. gondii are resistant to multiple inducers of apoptosis, including Fas-dependent and Fas-independent CTL-mediated cytotoxicity, IL-2 deprivation, gamma irradiation, UV irradiation, and the calcium ionophore beauvericin. Inhibition of such a broad array of apoptosis inducers suggests that a mechanism common to many, or perhaps all, apoptotic pathways is involved. The inhibitory activity requires live intracellular parasite and ongoing protein synthesis. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Anti-Bacterial Agents - antagonists & inhibitors Anti-Bacterial Agents - pharmacology Apoptosis - immunology Apoptosis - radiation effects Cell Line Cycloheximide - pharmacology Cytotoxicity, Immunologic - radiation effects Dactinomycin - pharmacology Depsipeptides Gamma Rays Humans Immunity, Innate - radiation effects Interleukin-2 - pharmacology Interleukin-2 - radiation effects Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Mice, Inbred DBA Peptides T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - parasitology T-Lymphocytes, Cytotoxic - radiation effects Toxoplasma - drug effects Toxoplasma - growth & development Toxoplasma - immunology Toxoplasma - radiation effects Tumor Cells, Cultured Ultraviolet Rays |
| title | Toxoplasma gondii-Infected Cells Are Resistant to Multiple Inducers of Apoptosis |
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