shibire, a neurogenic mutant of Drosophila
Embryos of the temperature-sensitive mutant shibire ts1 were given short exposures to the restrictive temperature during the stage when neuroblasts segregate from the presumptive epidermis. The resulting lethal phenotype, expansion of the nervous system at the expense of the epidermis, is characteri...
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| Veröffentlicht in: | Developmental biology 1990-04, Vol.138 (2), p.464-472 |
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| container_title | Developmental biology |
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| creator | Poodry, Clifton A. |
| description | Embryos of the temperature-sensitive mutant
shibire
ts1
were given short exposures to the restrictive temperature during the stage when neuroblasts segregate from the presumptive epidermis. The resulting lethal phenotype, expansion of the nervous system at the expense of the epidermis, is characteristic of a group of mutants called neurogenic mutants. Exposures as short as 20 min were sufficient to promote the neurogenic phenotype. Cell masses from heat-pulsed embryos could be cultured
in vivo as tumorous masses which retained some characteristics of neural tissue. An examination of the neurogenic region from heat-pulsed embryos revealed numerous packets of extracellular vesicles and coated pits blocked in endocytosis. |
| doi_str_mv | 10.1016/0012-1606(90)90212-2 |
| format | Article |
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shibire
ts1
were given short exposures to the restrictive temperature during the stage when neuroblasts segregate from the presumptive epidermis. The resulting lethal phenotype, expansion of the nervous system at the expense of the epidermis, is characteristic of a group of mutants called neurogenic mutants. Exposures as short as 20 min were sufficient to promote the neurogenic phenotype. Cell masses from heat-pulsed embryos could be cultured
in vivo as tumorous masses which retained some characteristics of neural tissue. An examination of the neurogenic region from heat-pulsed embryos revealed numerous packets of extracellular vesicles and coated pits blocked in endocytosis.</description><identifier>ISSN: 0012-1606</identifier><identifier>EISSN: 1095-564X</identifier><identifier>DOI: 10.1016/0012-1606(90)90212-2</identifier><identifier>PMID: 2108067</identifier><identifier>CODEN: DEBIAO</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>ABSORCION ; ABSORPTION ; Alleles ; ANIMAL EMBRYOS ; Animals ; Biological and medical sciences ; Classical genetics, quantitative genetics, hybrids ; DROSOPHILA ; DROSOPHILA MELANOGASTER ; Drosophila melanogaster - embryology ; Drosophila melanogaster - genetics ; Drosophila melanogaster - physiology ; EMBRIONES ANIMALES ; Embryo, Nonmammalian - cytology ; Embryo, Nonmammalian - physiology ; EMBRYON ANIMAL ; ENDOCYTOSIS ; FENOTIPOS ; Fundamental and applied biological sciences. Psychology ; Gastrula - physiology ; Gastrula - ultrastructure ; Genetics of eukaryotes. Biological and molecular evolution ; Hot Temperature ; Invertebrata ; Microscopy, Electron, Scanning ; MUTANT ; MUTANTES ; MUTANTS ; Mutation ; Nervous System - embryology ; Nervous System - ultrastructure ; Nervous System Physiological Phenomena ; PHENOTYPE ; PHENOTYPES ; TEMPERATURA ; TEMPERATURE ; VESICLES</subject><ispartof>Developmental biology, 1990-04, Vol.138 (2), p.464-472</ispartof><rights>1990</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-fe36210800c4f6c595e6fc45c68ee7e68ab3f67bf854987d6aa7717527a8ff7a3</citedby><cites>FETCH-LOGICAL-c405t-fe36210800c4f6c595e6fc45c68ee7e68ab3f67bf854987d6aa7717527a8ff7a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0012-1606(90)90212-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6947161$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2108067$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Poodry, Clifton A.</creatorcontrib><title>shibire, a neurogenic mutant of Drosophila</title><title>Developmental biology</title><addtitle>Dev Biol</addtitle><description>Embryos of the temperature-sensitive mutant
shibire
ts1
were given short exposures to the restrictive temperature during the stage when neuroblasts segregate from the presumptive epidermis. The resulting lethal phenotype, expansion of the nervous system at the expense of the epidermis, is characteristic of a group of mutants called neurogenic mutants. Exposures as short as 20 min were sufficient to promote the neurogenic phenotype. Cell masses from heat-pulsed embryos could be cultured
in vivo as tumorous masses which retained some characteristics of neural tissue. An examination of the neurogenic region from heat-pulsed embryos revealed numerous packets of extracellular vesicles and coated pits blocked in endocytosis.</description><subject>ABSORCION</subject><subject>ABSORPTION</subject><subject>Alleles</subject><subject>ANIMAL EMBRYOS</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>DROSOPHILA</subject><subject>DROSOPHILA MELANOGASTER</subject><subject>Drosophila melanogaster - embryology</subject><subject>Drosophila melanogaster - genetics</subject><subject>Drosophila melanogaster - physiology</subject><subject>EMBRIONES ANIMALES</subject><subject>Embryo, Nonmammalian - cytology</subject><subject>Embryo, Nonmammalian - physiology</subject><subject>EMBRYON ANIMAL</subject><subject>ENDOCYTOSIS</subject><subject>FENOTIPOS</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastrula - physiology</subject><subject>Gastrula - ultrastructure</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Hot Temperature</subject><subject>Invertebrata</subject><subject>Microscopy, Electron, Scanning</subject><subject>MUTANT</subject><subject>MUTANTES</subject><subject>MUTANTS</subject><subject>Mutation</subject><subject>Nervous System - embryology</subject><subject>Nervous System - ultrastructure</subject><subject>Nervous System Physiological Phenomena</subject><subject>PHENOTYPE</subject><subject>PHENOTYPES</subject><subject>TEMPERATURA</subject><subject>TEMPERATURE</subject><subject>VESICLES</subject><issn>0012-1606</issn><issn>1095-564X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMoWqt_QBT2IKLi6mR383URpH6C4EEFbyFNJxrZ7tZkV_Dfm9rSo5cZhveZl5mXkH0K5xQovwCgRU458GMFJwqKNBVrZEBBsZzx6m2dDFbIFtmO8RMASinLTbJZUJDAxYCcxg8_9gHPMpM12If2HRtvs2nfmabLWpddhza2sw9fmx2y4UwdcXfZh-T19uZldJ8_Pt09jK4ec1sB63KHJf-zB1s5bpliyJ2tmOUSUSCXZlw6LsZOskpJMeHGCEEFK4SRzglTDsnRwncW2q8eY6enPlqsa9Ng20ctFJeMlWUCqwVo040xoNOz4Kcm_GgKeh6Rnv-v5_9rBfovIl2ktYOlfz-e4mS1tMwk6YdL3URrahdMY31cYVxVgnKasL0F5kyrzXtIyOuzgpJWqQzJ5ULEFNS3x6Cj9dhYnKSsbacnrf__yF-dmohB</recordid><startdate>19900401</startdate><enddate>19900401</enddate><creator>Poodry, Clifton A.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900401</creationdate><title>shibire, a neurogenic mutant of Drosophila</title><author>Poodry, Clifton A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-fe36210800c4f6c595e6fc45c68ee7e68ab3f67bf854987d6aa7717527a8ff7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>ABSORCION</topic><topic>ABSORPTION</topic><topic>Alleles</topic><topic>ANIMAL EMBRYOS</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>DROSOPHILA</topic><topic>DROSOPHILA MELANOGASTER</topic><topic>Drosophila melanogaster - embryology</topic><topic>Drosophila melanogaster - genetics</topic><topic>Drosophila melanogaster - physiology</topic><topic>EMBRIONES ANIMALES</topic><topic>Embryo, Nonmammalian - cytology</topic><topic>Embryo, Nonmammalian - physiology</topic><topic>EMBRYON ANIMAL</topic><topic>ENDOCYTOSIS</topic><topic>FENOTIPOS</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastrula - physiology</topic><topic>Gastrula - ultrastructure</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Hot Temperature</topic><topic>Invertebrata</topic><topic>Microscopy, Electron, Scanning</topic><topic>MUTANT</topic><topic>MUTANTES</topic><topic>MUTANTS</topic><topic>Mutation</topic><topic>Nervous System - embryology</topic><topic>Nervous System - ultrastructure</topic><topic>Nervous System Physiological Phenomena</topic><topic>PHENOTYPE</topic><topic>PHENOTYPES</topic><topic>TEMPERATURA</topic><topic>TEMPERATURE</topic><topic>VESICLES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Poodry, Clifton A.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Poodry, Clifton A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>shibire, a neurogenic mutant of Drosophila</atitle><jtitle>Developmental biology</jtitle><addtitle>Dev Biol</addtitle><date>1990-04-01</date><risdate>1990</risdate><volume>138</volume><issue>2</issue><spage>464</spage><epage>472</epage><pages>464-472</pages><issn>0012-1606</issn><eissn>1095-564X</eissn><coden>DEBIAO</coden><abstract>Embryos of the temperature-sensitive mutant
shibire
ts1
were given short exposures to the restrictive temperature during the stage when neuroblasts segregate from the presumptive epidermis. The resulting lethal phenotype, expansion of the nervous system at the expense of the epidermis, is characteristic of a group of mutants called neurogenic mutants. Exposures as short as 20 min were sufficient to promote the neurogenic phenotype. Cell masses from heat-pulsed embryos could be cultured
in vivo as tumorous masses which retained some characteristics of neural tissue. An examination of the neurogenic region from heat-pulsed embryos revealed numerous packets of extracellular vesicles and coated pits blocked in endocytosis.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>2108067</pmid><doi>10.1016/0012-1606(90)90212-2</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-1606 |
| ispartof | Developmental biology, 1990-04, Vol.138 (2), p.464-472 |
| issn | 0012-1606 1095-564X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79685533 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | ABSORCION ABSORPTION Alleles ANIMAL EMBRYOS Animals Biological and medical sciences Classical genetics, quantitative genetics, hybrids DROSOPHILA DROSOPHILA MELANOGASTER Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila melanogaster - physiology EMBRIONES ANIMALES Embryo, Nonmammalian - cytology Embryo, Nonmammalian - physiology EMBRYON ANIMAL ENDOCYTOSIS FENOTIPOS Fundamental and applied biological sciences. Psychology Gastrula - physiology Gastrula - ultrastructure Genetics of eukaryotes. Biological and molecular evolution Hot Temperature Invertebrata Microscopy, Electron, Scanning MUTANT MUTANTES MUTANTS Mutation Nervous System - embryology Nervous System - ultrastructure Nervous System Physiological Phenomena PHENOTYPE PHENOTYPES TEMPERATURA TEMPERATURE VESICLES |
| title | shibire, a neurogenic mutant of Drosophila |
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