Human and Mouse Chromosomal Mapping of Stac, a Neuron-Specific Protein with an SH3 Domain
Stac is a novel neuron-specific protein consisting of a cysteine-rich domain and an SH3 domain. We determined the chromosomal location of both the mouse and the human Stac genes (StacandSTAC). By linkage analysis using a mouse recombinant inbred (RI) strain panel (BXD), it was determined thatStacis...
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| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 1998-01, Vol.47 (1), p.140-142 |
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| container_title | Genomics (San Diego, Calif.) |
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| creator | Kawai, Jun Suzuki, Harukazu Hara, Ayako Hirose, Kenji Watanabe, Sachihiko |
| description | Stac is a novel neuron-specific protein consisting of a cysteine-rich domain and an SH3 domain. We determined the chromosomal location of both the mouse and the human Stac genes (StacandSTAC). By linkage analysis using a mouse recombinant inbred (RI) strain panel (BXD), it was determined thatStacis located betweenD9mit15andD9mit20at the distal region of chromosome 9, around which two neurological disease genes,duandtip, have been found. This result was also supported by analysis using an interspecific backcross panel BSS. The mouse chromosomal location aroundStacwas syntenic with the human chromosome around 3p21–p23, where the gene for cerebellar ataxia (ADCA type II) was recently mapped. By radiation hybrid mapping,STACwas assigned to human chromosome 3p22–p24, and it was found to be distinct from the ADCA type II locus. |
| doi_str_mv | 10.1006/geno.1997.5107 |
| format | Article |
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We determined the chromosomal location of both the mouse and the human Stac genes (StacandSTAC). By linkage analysis using a mouse recombinant inbred (RI) strain panel (BXD), it was determined thatStacis located betweenD9mit15andD9mit20at the distal region of chromosome 9, around which two neurological disease genes,duandtip, have been found. This result was also supported by analysis using an interspecific backcross panel BSS. The mouse chromosomal location aroundStacwas syntenic with the human chromosome around 3p21–p23, where the gene for cerebellar ataxia (ADCA type II) was recently mapped. By radiation hybrid mapping,STACwas assigned to human chromosome 3p22–p24, and it was found to be distinct from the ADCA type II locus.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1006/geno.1997.5107</identifier><identifier>PMID: 9465308</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Blotting, Northern ; Blotting, Western ; Brain - metabolism ; Chromosome Mapping ; Chromosomes, Human, Pair 3 ; Classical genetics, quantitative genetics, hybrids ; Fundamental and applied biological sciences. Psychology ; Genetic Markers ; Genetics of eukaryotes. Biological and molecular evolution ; Human ; Humans ; Hybrid Cells - radiation effects ; Mice ; Mice, Inbred DBA ; Mice, Inbred Strains ; Mice, Neurologic Mutants ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - metabolism ; src Homology Domains</subject><ispartof>Genomics (San Diego, Calif.), 1998-01, Vol.47 (1), p.140-142</ispartof><rights>1998 Academic Press</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-3f1d97f8fcaa33cd08de957ed67dd0fd54cad722effc29f66ec8db0cdc35461e3</citedby><cites>FETCH-LOGICAL-c399t-3f1d97f8fcaa33cd08de957ed67dd0fd54cad722effc29f66ec8db0cdc35461e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/geno.1997.5107$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2142001$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9465308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawai, Jun</creatorcontrib><creatorcontrib>Suzuki, Harukazu</creatorcontrib><creatorcontrib>Hara, Ayako</creatorcontrib><creatorcontrib>Hirose, Kenji</creatorcontrib><creatorcontrib>Watanabe, Sachihiko</creatorcontrib><title>Human and Mouse Chromosomal Mapping of Stac, a Neuron-Specific Protein with an SH3 Domain</title><title>Genomics (San Diego, Calif.)</title><addtitle>Genomics</addtitle><description>Stac is a novel neuron-specific protein consisting of a cysteine-rich domain and an SH3 domain. We determined the chromosomal location of both the mouse and the human Stac genes (StacandSTAC). By linkage analysis using a mouse recombinant inbred (RI) strain panel (BXD), it was determined thatStacis located betweenD9mit15andD9mit20at the distal region of chromosome 9, around which two neurological disease genes,duandtip, have been found. This result was also supported by analysis using an interspecific backcross panel BSS. The mouse chromosomal location aroundStacwas syntenic with the human chromosome around 3p21–p23, where the gene for cerebellar ataxia (ADCA type II) was recently mapped. By radiation hybrid mapping,STACwas assigned to human chromosome 3p22–p24, and it was found to be distinct from the ADCA type II locus.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Blotting, Western</subject><subject>Brain - metabolism</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 3</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Markers</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Human</subject><subject>Humans</subject><subject>Hybrid Cells - radiation effects</subject><subject>Mice</subject><subject>Mice, Inbred DBA</subject><subject>Mice, Inbred Strains</subject><subject>Mice, Neurologic Mutants</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>src Homology Domains</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1vFDEQhi1EFC6Blg7JBaLKHvZ61x8lOhIOKQGkg4LKcuxxYrRrb-xdIv49Pt0pHaKaYp731cyD0GtK1pQQ_v4OYlpTpcS6p0Q8QytKpGok7_hztCJSykb0HXuBzkr5RQhRTLan6FR1vGdErtDP7TKaiE10-CYtBfDmPqcxlTSaAd-YaQrxDiePd7OxF9jgL7DkFJvdBDb4YPG3nGYIET-G-b624N2W4Y81HOJLdOLNUODVcZ6jH1eX3zfb5vrrp8-bD9eNZUrNDfPUKeGlt8YwZh2RDlQvwHHhHPGu76xxom3Be9sqzzlY6W6JdZb1HafAztG7Q--U08MCZdZjKBaGwUSoH2mhuOy76uB_IBWUUKFYBdcH0OZUSgavpxxGk_9oSvReut5L13vpei-9Bt4cm5fbEdwTfrRc92-Pe1OsGXw20YbyhLW0awmhFZMHDKqu3wGyLjZAtOBCBjtrl8K_LvgLTICdkQ</recordid><startdate>19980101</startdate><enddate>19980101</enddate><creator>Kawai, Jun</creator><creator>Suzuki, Harukazu</creator><creator>Hara, Ayako</creator><creator>Hirose, Kenji</creator><creator>Watanabe, Sachihiko</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19980101</creationdate><title>Human and Mouse Chromosomal Mapping of Stac, a Neuron-Specific Protein with an SH3 Domain</title><author>Kawai, Jun ; Suzuki, Harukazu ; Hara, Ayako ; Hirose, Kenji ; Watanabe, Sachihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-3f1d97f8fcaa33cd08de957ed67dd0fd54cad722effc29f66ec8db0cdc35461e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Blotting, Western</topic><topic>Brain - metabolism</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 3</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Markers</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Human</topic><topic>Humans</topic><topic>Hybrid Cells - radiation effects</topic><topic>Mice</topic><topic>Mice, Inbred DBA</topic><topic>Mice, Inbred Strains</topic><topic>Mice, Neurologic Mutants</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>src Homology Domains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawai, Jun</creatorcontrib><creatorcontrib>Suzuki, Harukazu</creatorcontrib><creatorcontrib>Hara, Ayako</creatorcontrib><creatorcontrib>Hirose, Kenji</creatorcontrib><creatorcontrib>Watanabe, Sachihiko</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genomics (San Diego, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawai, Jun</au><au>Suzuki, Harukazu</au><au>Hara, Ayako</au><au>Hirose, Kenji</au><au>Watanabe, Sachihiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human and Mouse Chromosomal Mapping of Stac, a Neuron-Specific Protein with an SH3 Domain</atitle><jtitle>Genomics (San Diego, Calif.)</jtitle><addtitle>Genomics</addtitle><date>1998-01-01</date><risdate>1998</risdate><volume>47</volume><issue>1</issue><spage>140</spage><epage>142</epage><pages>140-142</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>Stac is a novel neuron-specific protein consisting of a cysteine-rich domain and an SH3 domain. We determined the chromosomal location of both the mouse and the human Stac genes (StacandSTAC). By linkage analysis using a mouse recombinant inbred (RI) strain panel (BXD), it was determined thatStacis located betweenD9mit15andD9mit20at the distal region of chromosome 9, around which two neurological disease genes,duandtip, have been found. This result was also supported by analysis using an interspecific backcross panel BSS. The mouse chromosomal location aroundStacwas syntenic with the human chromosome around 3p21–p23, where the gene for cerebellar ataxia (ADCA type II) was recently mapped. By radiation hybrid mapping,STACwas assigned to human chromosome 3p22–p24, and it was found to be distinct from the ADCA type II locus.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>9465308</pmid><doi>10.1006/geno.1997.5107</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Blotting, Northern Blotting, Western Brain - metabolism Chromosome Mapping Chromosomes, Human, Pair 3 Classical genetics, quantitative genetics, hybrids Fundamental and applied biological sciences. Psychology Genetic Markers Genetics of eukaryotes. Biological and molecular evolution Human Humans Hybrid Cells - radiation effects Mice Mice, Inbred DBA Mice, Inbred Strains Mice, Neurologic Mutants Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism src Homology Domains |
| title | Human and Mouse Chromosomal Mapping of Stac, a Neuron-Specific Protein with an SH3 Domain |
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