Human and Mouse Chromosomal Mapping of Stac, a Neuron-Specific Protein with an SH3 Domain

Stac is a novel neuron-specific protein consisting of a cysteine-rich domain and an SH3 domain. We determined the chromosomal location of both the mouse and the human Stac genes (StacandSTAC). By linkage analysis using a mouse recombinant inbred (RI) strain panel (BXD), it was determined thatStacis located betweenD9mit15andD9mit20at the distal region of chromosome 9, around which two neurological disease genes,duandtip, have been found. This result was also supported by analysis using an interspecific backcross panel BSS. The mouse chromosomal location aroundStacwas syntenic with the human chromosome around 3p21–p23, where the gene for cerebellar ataxia (ADCA type II) was recently mapped. By radiation hybrid mapping,STACwas assigned to human chromosome 3p22–p24, and it was found to be distinct from the ADCA type II locus.