Single-dose antibiotic prophylaxis for patients undergoing extended pelvic surgery for gynecologic malignancy
The comparative efficacy of single-dose antibiotic prophylaxis was retrospectively evaluated in 116 patients undergoing extended pelvic surgical procedures with curative intent. During the 24-month period, other important variables such as surgeon's experience, duration of preoperative hospital...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1990-03, Vol.162 (3), p.718-721 |
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| container_title | American journal of obstetrics and gynecology |
| container_volume | 162 |
| creator | Orr, James W. Sisson, Pamela F. Patsner, Bruce Barrett, Jeffrey M. Ellington, John R. Jennings, Ralph Henry Paredes, Keith B. Taylor, Dale L. Soong, Seng Jaw Roe, Cathy |
| description | The comparative efficacy of single-dose antibiotic prophylaxis was retrospectively evaluated in 116 patients undergoing extended pelvic surgical procedures with curative intent. During the 24-month period, other important variables such as surgeon's experience, duration of preoperative hospitalization, preoperative preparation, method of hair removal, suture type, suture size, use of drains, use of cautery, and abdominal closure were controlled. The overall surgical site infection rate was 4.3% after radical hysterectomy with lymphadenectomy and 4.5% after total hysterectomy with lymphadenectomy. In this clinical situation the use of a single dose of antibiotic prophylaxis theoretically decreases cost and patient exposure and appears to be as efficacious as a multiple-dose regimen. |
| doi_str_mv | 10.1016/0002-9378(90)90993-H |
| format | Article |
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During the 24-month period, other important variables such as surgeon's experience, duration of preoperative hospitalization, preoperative preparation, method of hair removal, suture type, suture size, use of drains, use of cautery, and abdominal closure were controlled. The overall surgical site infection rate was 4.3% after radical hysterectomy with lymphadenectomy and 4.5% after total hysterectomy with lymphadenectomy. In this clinical situation the use of a single dose of antibiotic prophylaxis theoretically decreases cost and patient exposure and appears to be as efficacious as a multiple-dose regimen.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/0002-9378(90)90993-H</identifier><identifier>PMID: 2316576</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Mosby, Inc</publisher><subject>Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - therapeutic use ; Antibiotic prophylaxis ; Biological and medical sciences ; cancer ; Cephalosporins - therapeutic use ; Drug Administration Schedule ; Female ; Genital Neoplasms, Female - surgery ; Humans ; Hysterectomy ; Lymph Nodes - surgery ; Medical sciences ; Metronidazole - therapeutic use ; Pelvis - surgery ; surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the genital tract and mammary gland ; Surgical Wound Infection - prevention & control</subject><ispartof>American journal of obstetrics and gynecology, 1990-03, Vol.162 (3), p.718-721</ispartof><rights>1990 Mosby</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-23dd2b970b3c5163d365515630db135f6e2dfd7b0d2ef3ab3640ff6092a3b8aa3</citedby><cites>FETCH-LOGICAL-c386t-23dd2b970b3c5163d365515630db135f6e2dfd7b0d2ef3ab3640ff6092a3b8aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9378(90)90993-H$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6951536$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2316576$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Orr, James W.</creatorcontrib><creatorcontrib>Sisson, Pamela F.</creatorcontrib><creatorcontrib>Patsner, Bruce</creatorcontrib><creatorcontrib>Barrett, Jeffrey M.</creatorcontrib><creatorcontrib>Ellington, John R.</creatorcontrib><creatorcontrib>Jennings, Ralph Henry</creatorcontrib><creatorcontrib>Paredes, Keith B.</creatorcontrib><creatorcontrib>Taylor, Dale L.</creatorcontrib><creatorcontrib>Soong, Seng Jaw</creatorcontrib><creatorcontrib>Roe, Cathy</creatorcontrib><title>Single-dose antibiotic prophylaxis for patients undergoing extended pelvic surgery for gynecologic malignancy</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>The comparative efficacy of single-dose antibiotic prophylaxis was retrospectively evaluated in 116 patients undergoing extended pelvic surgical procedures with curative intent. During the 24-month period, other important variables such as surgeon's experience, duration of preoperative hospitalization, preoperative preparation, method of hair removal, suture type, suture size, use of drains, use of cautery, and abdominal closure were controlled. The overall surgical site infection rate was 4.3% after radical hysterectomy with lymphadenectomy and 4.5% after total hysterectomy with lymphadenectomy. In this clinical situation the use of a single dose of antibiotic prophylaxis theoretically decreases cost and patient exposure and appears to be as efficacious as a multiple-dose regimen.</description><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotic prophylaxis</subject><subject>Biological and medical sciences</subject><subject>cancer</subject><subject>Cephalosporins - therapeutic use</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Genital Neoplasms, Female - surgery</subject><subject>Humans</subject><subject>Hysterectomy</subject><subject>Lymph Nodes - surgery</subject><subject>Medical sciences</subject><subject>Metronidazole - therapeutic use</subject><subject>Pelvis - surgery</subject><subject>surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the genital tract and mammary gland</subject><subject>Surgical Wound Infection - prevention & control</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVJSbZp_0ECPoTSHtzoYy1bl0IJbbcQ6KHpWcjSyFGQLUeyl_jfV84ue-xJjOZ5h5kHoSuCvxBM-C3GmJaC1c0ngT8LLAQrd2_QhmBRl7zhzRnanJAL9C6lp7Wkgp6jc8oIr2q-Qf0fN3QeShMSFGqYXOvC5HQxxjA-Ll69uFTYEItRTQ6GKRXzYCB2IacKeJkgV6YYwe9zJs2xg7i88t0ygA4-dPm_V951gxr08h69tcon-HB8L9HfH98f7nbl_e-fv-6-3ZeaNXwqKTOGtqLGLdMV4cwwXlWk4gyblrDKcqDGmrrFhoJlqmV8i63lWFDF2kYpdok-HubmM55nSJPsXdLgvRogzEnWgjfbhtYZ3B5AHUNKEawco-tVXCTBcrUsV2dyVSgFlq-W5S7Hro_z57YHcwodteb-zbGvklbexny8SyeMi3wNW7GvBwyyi72DKJPOljUYF0FP0gT3_z3-AbdHm4E</recordid><startdate>19900301</startdate><enddate>19900301</enddate><creator>Orr, James W.</creator><creator>Sisson, Pamela F.</creator><creator>Patsner, Bruce</creator><creator>Barrett, Jeffrey M.</creator><creator>Ellington, John R.</creator><creator>Jennings, Ralph Henry</creator><creator>Paredes, Keith B.</creator><creator>Taylor, Dale L.</creator><creator>Soong, Seng Jaw</creator><creator>Roe, Cathy</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900301</creationdate><title>Single-dose antibiotic prophylaxis for patients undergoing extended pelvic surgery for gynecologic malignancy</title><author>Orr, James W. ; Sisson, Pamela F. ; Patsner, Bruce ; Barrett, Jeffrey M. ; Ellington, John R. ; Jennings, Ralph Henry ; Paredes, Keith B. ; Taylor, Dale L. ; Soong, Seng Jaw ; Roe, Cathy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-23dd2b970b3c5163d365515630db135f6e2dfd7b0d2ef3ab3640ff6092a3b8aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotic prophylaxis</topic><topic>Biological and medical sciences</topic><topic>cancer</topic><topic>Cephalosporins - therapeutic use</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Genital Neoplasms, Female - surgery</topic><topic>Humans</topic><topic>Hysterectomy</topic><topic>Lymph Nodes - surgery</topic><topic>Medical sciences</topic><topic>Metronidazole - therapeutic use</topic><topic>Pelvis - surgery</topic><topic>surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the genital tract and mammary gland</topic><topic>Surgical Wound Infection - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Orr, James W.</creatorcontrib><creatorcontrib>Sisson, Pamela F.</creatorcontrib><creatorcontrib>Patsner, Bruce</creatorcontrib><creatorcontrib>Barrett, Jeffrey M.</creatorcontrib><creatorcontrib>Ellington, John R.</creatorcontrib><creatorcontrib>Jennings, Ralph Henry</creatorcontrib><creatorcontrib>Paredes, Keith B.</creatorcontrib><creatorcontrib>Taylor, Dale L.</creatorcontrib><creatorcontrib>Soong, Seng Jaw</creatorcontrib><creatorcontrib>Roe, Cathy</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Orr, James W.</au><au>Sisson, Pamela F.</au><au>Patsner, Bruce</au><au>Barrett, Jeffrey M.</au><au>Ellington, John R.</au><au>Jennings, Ralph Henry</au><au>Paredes, Keith B.</au><au>Taylor, Dale L.</au><au>Soong, Seng Jaw</au><au>Roe, Cathy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single-dose antibiotic prophylaxis for patients undergoing extended pelvic surgery for gynecologic malignancy</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1990-03-01</date><risdate>1990</risdate><volume>162</volume><issue>3</issue><spage>718</spage><epage>721</epage><pages>718-721</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>The comparative efficacy of single-dose antibiotic prophylaxis was retrospectively evaluated in 116 patients undergoing extended pelvic surgical procedures with curative intent. During the 24-month period, other important variables such as surgeon's experience, duration of preoperative hospitalization, preoperative preparation, method of hair removal, suture type, suture size, use of drains, use of cautery, and abdominal closure were controlled. The overall surgical site infection rate was 4.3% after radical hysterectomy with lymphadenectomy and 4.5% after total hysterectomy with lymphadenectomy. In this clinical situation the use of a single dose of antibiotic prophylaxis theoretically decreases cost and patient exposure and appears to be as efficacious as a multiple-dose regimen.</abstract><cop>Philadelphia, PA</cop><pub>Mosby, Inc</pub><pmid>2316576</pmid><doi>10.1016/0002-9378(90)90993-H</doi><tpages>4</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 1990-03, Vol.162 (3), p.718-721 |
| issn | 0002-9378 1097-6868 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Antibiotic prophylaxis Biological and medical sciences cancer Cephalosporins - therapeutic use Drug Administration Schedule Female Genital Neoplasms, Female - surgery Humans Hysterectomy Lymph Nodes - surgery Medical sciences Metronidazole - therapeutic use Pelvis - surgery surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the genital tract and mammary gland Surgical Wound Infection - prevention & control |
| title | Single-dose antibiotic prophylaxis for patients undergoing extended pelvic surgery for gynecologic malignancy |
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