The Opsonic Antibody Response of Female Rats to Type III Group B Streptococcal Immunization: a Model for Maternal Immunity
Group B streptococcus (GBS) remains a major cause of neonatal infection. Maternal immunization-induced GBS antibody may protect neonates from GBS disease. Since the opsonophagocytosis assay correlates well with survival in GBS infected suckling rats, we sought to determine an immunization schedule w...
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| Veröffentlicht in: | Veterinary immunology and immunopathology 1990, Vol.24 (1), p.79-89 |
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| creator | Heiman, Howard S. Weisman, Leonard E. |
| description | Group B streptococcus (GBS) remains a major cause of neonatal infection. Maternal immunization-induced GBS antibody may protect neonates from GBS disease. Since the opsonophagocytosis assay correlates well with survival in GBS infected suckling rats, we sought to determine an immunization schedule which would induce type III GBS opsonic antibody in rat dams above a predetermined level of 10 dilution
−1 (dil
−1). This schedule could then be used for future studies of maternal-fetal immunity. Wistar rat dams (
n=12) were given killed GBS type III using three immunization schedules (primary injection, initial booster at 7, 14 or 22 days and then weekly boosters). Opsonic GBS type III antibody and total immunoglobulin (IgG) were measured. Only the schedule with a 7-day initial booster resulted in GBS type-specific opsonic antibody consistently above 10 dil
−1. The IgG (467±83 mg/100 ml) remained constant while the opsonic antibody increased significantly to 50 and 63 dil
−1 (
P |
| doi_str_mv | 10.1016/0165-2427(90)90079-8 |
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−1 (dil
−1). This schedule could then be used for future studies of maternal-fetal immunity. Wistar rat dams (
n=12) were given killed GBS type III using three immunization schedules (primary injection, initial booster at 7, 14 or 22 days and then weekly boosters). Opsonic GBS type III antibody and total immunoglobulin (IgG) were measured. Only the schedule with a 7-day initial booster resulted in GBS type-specific opsonic antibody consistently above 10 dil
−1. The IgG (467±83 mg/100 ml) remained constant while the opsonic antibody increased significantly to 50 and 63 dil
−1 (
P<0.01 compared to day 0) after boosters on day 7 and 14 respectively. Eight pregnant dams, who received a primary immunization and boosters at 7 and 14 days, developed GBS type III opsonic antibody titers (72 dil
−1) similar to non-pregnant dams and potentially adequate to protect suckling rats from GBS disease. This model may now be used to study other adjuvants, immunogens, and maternal-fetal immunity using established suckling rat models of GBS disease.</description><identifier>ISSN: 0165-2427</identifier><identifier>EISSN: 1873-2534</identifier><identifier>DOI: 10.1016/0165-2427(90)90079-8</identifier><identifier>PMID: 2180204</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Analysis of Variance ; Animals ; Antibodies, Bacterial - biosynthesis ; Antibodies, Bacterial - immunology ; Bacterial Vaccines - administration & dosage ; Bacterial Vaccines - immunology ; Female ; Immunity, Maternally-Acquired - immunology ; Immunization ; Immunization Schedule ; Immunization, Passive ; Immunization, Secondary ; Immunoglobulin G - biosynthesis ; Immunoglobulin G - immunology ; Models, Biological ; Opsonin Proteins - immunology ; Pregnancy ; Pregnancy Complications, Infectious - immunology ; Pregnancy Complications, Infectious - prevention & control ; Rats ; Rats, Inbred Strains ; Streptococcal Infections - prevention & control ; Streptococcus agalactiae - immunology ; Vaccines, Inactivated - administration & dosage ; Vaccines, Inactivated - immunology</subject><ispartof>Veterinary immunology and immunopathology, 1990, Vol.24 (1), p.79-89</ispartof><rights>1990</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-7338e756dc80371e43beef9e2a1fc58ef836d69f7dee5ba8f9e03915c922b1a43</citedby><cites>FETCH-LOGICAL-c388t-7338e756dc80371e43beef9e2a1fc58ef836d69f7dee5ba8f9e03915c922b1a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0165-2427(90)90079-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2180204$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heiman, Howard S.</creatorcontrib><creatorcontrib>Weisman, Leonard E.</creatorcontrib><title>The Opsonic Antibody Response of Female Rats to Type III Group B Streptococcal Immunization: a Model for Maternal Immunity</title><title>Veterinary immunology and immunopathology</title><addtitle>Vet Immunol Immunopathol</addtitle><description>Group B streptococcus (GBS) remains a major cause of neonatal infection. Maternal immunization-induced GBS antibody may protect neonates from GBS disease. Since the opsonophagocytosis assay correlates well with survival in GBS infected suckling rats, we sought to determine an immunization schedule which would induce type III GBS opsonic antibody in rat dams above a predetermined level of 10 dilution
−1 (dil
−1). This schedule could then be used for future studies of maternal-fetal immunity. Wistar rat dams (
n=12) were given killed GBS type III using three immunization schedules (primary injection, initial booster at 7, 14 or 22 days and then weekly boosters). Opsonic GBS type III antibody and total immunoglobulin (IgG) were measured. Only the schedule with a 7-day initial booster resulted in GBS type-specific opsonic antibody consistently above 10 dil
−1. The IgG (467±83 mg/100 ml) remained constant while the opsonic antibody increased significantly to 50 and 63 dil
−1 (
P<0.01 compared to day 0) after boosters on day 7 and 14 respectively. Eight pregnant dams, who received a primary immunization and boosters at 7 and 14 days, developed GBS type III opsonic antibody titers (72 dil
−1) similar to non-pregnant dams and potentially adequate to protect suckling rats from GBS disease. This model may now be used to study other adjuvants, immunogens, and maternal-fetal immunity using established suckling rat models of GBS disease.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Antibodies, Bacterial - biosynthesis</subject><subject>Antibodies, Bacterial - immunology</subject><subject>Bacterial Vaccines - administration & dosage</subject><subject>Bacterial Vaccines - immunology</subject><subject>Female</subject><subject>Immunity, Maternally-Acquired - immunology</subject><subject>Immunization</subject><subject>Immunization Schedule</subject><subject>Immunization, Passive</subject><subject>Immunization, Secondary</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Immunoglobulin G - immunology</subject><subject>Models, Biological</subject><subject>Opsonin Proteins - immunology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - immunology</subject><subject>Pregnancy Complications, Infectious - prevention & control</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Streptococcal Infections - prevention & control</subject><subject>Streptococcus agalactiae - immunology</subject><subject>Vaccines, Inactivated - administration & dosage</subject><subject>Vaccines, Inactivated - immunology</subject><issn>0165-2427</issn><issn>1873-2534</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EKkvhH4A0JwSHgB07sc2hUqloidSqUlnOluNMhFESB9tB2v56suxqj3AYzeF9b0Z6j5DXjH5glNUf16mKUpTynabvNaVSF-oJ2TAleVFWXDwlmxPynLxI6SeltNJKnZGzkilaUrEhj9sfCPdzCpN3cDll34ZuBw-Y5jAlhNDDNY52QHiwOUEOsN3NCE3TwE0Mywyf4VuOOOfggnN2gGYcl8k_2uzD9Aks3IUOB-hDhDubMU4nJO9ekme9HRK-Ou5z8v36y_bqa3F7f9NcXd4WjiuVC8m5QlnVnVOUS4aCt4i9xtKy3lUKe8Xrrta97BCr1qpVolyzyumybJkV_Jy8PdydY_i1YMpm9MnhMNgJw5KM1LUSVMr_gqwSimlRr6A4gC6GlCL2Zo5-tHFnGDX7bsw-eLMP3mhq_nZj1Gp7c7y_tCN2J9OxjFW_OOi4pvHbYzTJeZwcdj6iy6YL_t8P_gD-T54N</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Heiman, Howard S.</creator><creator>Weisman, Leonard E.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>The Opsonic Antibody Response of Female Rats to Type III Group B Streptococcal Immunization: a Model for Maternal Immunity</title><author>Heiman, Howard S. ; Weisman, Leonard E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-7338e756dc80371e43beef9e2a1fc58ef836d69f7dee5ba8f9e03915c922b1a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Antibodies, Bacterial - biosynthesis</topic><topic>Antibodies, Bacterial - immunology</topic><topic>Bacterial Vaccines - administration & dosage</topic><topic>Bacterial Vaccines - immunology</topic><topic>Female</topic><topic>Immunity, Maternally-Acquired - immunology</topic><topic>Immunization</topic><topic>Immunization Schedule</topic><topic>Immunization, Passive</topic><topic>Immunization, Secondary</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Immunoglobulin G - immunology</topic><topic>Models, Biological</topic><topic>Opsonin Proteins - immunology</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - immunology</topic><topic>Pregnancy Complications, Infectious - prevention & control</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Streptococcal Infections - prevention & control</topic><topic>Streptococcus agalactiae - immunology</topic><topic>Vaccines, Inactivated - administration & dosage</topic><topic>Vaccines, Inactivated - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heiman, Howard S.</creatorcontrib><creatorcontrib>Weisman, Leonard E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heiman, Howard S.</au><au>Weisman, Leonard E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Opsonic Antibody Response of Female Rats to Type III Group B Streptococcal Immunization: a Model for Maternal Immunity</atitle><jtitle>Veterinary immunology and immunopathology</jtitle><addtitle>Vet Immunol Immunopathol</addtitle><date>1990</date><risdate>1990</risdate><volume>24</volume><issue>1</issue><spage>79</spage><epage>89</epage><pages>79-89</pages><issn>0165-2427</issn><eissn>1873-2534</eissn><abstract>Group B streptococcus (GBS) remains a major cause of neonatal infection. Maternal immunization-induced GBS antibody may protect neonates from GBS disease. Since the opsonophagocytosis assay correlates well with survival in GBS infected suckling rats, we sought to determine an immunization schedule which would induce type III GBS opsonic antibody in rat dams above a predetermined level of 10 dilution
−1 (dil
−1). This schedule could then be used for future studies of maternal-fetal immunity. Wistar rat dams (
n=12) were given killed GBS type III using three immunization schedules (primary injection, initial booster at 7, 14 or 22 days and then weekly boosters). Opsonic GBS type III antibody and total immunoglobulin (IgG) were measured. Only the schedule with a 7-day initial booster resulted in GBS type-specific opsonic antibody consistently above 10 dil
−1. The IgG (467±83 mg/100 ml) remained constant while the opsonic antibody increased significantly to 50 and 63 dil
−1 (
P<0.01 compared to day 0) after boosters on day 7 and 14 respectively. Eight pregnant dams, who received a primary immunization and boosters at 7 and 14 days, developed GBS type III opsonic antibody titers (72 dil
−1) similar to non-pregnant dams and potentially adequate to protect suckling rats from GBS disease. This model may now be used to study other adjuvants, immunogens, and maternal-fetal immunity using established suckling rat models of GBS disease.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>2180204</pmid><doi>10.1016/0165-2427(90)90079-8</doi><tpages>11</tpages></addata></record> |
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| subjects | Analysis of Variance Animals Antibodies, Bacterial - biosynthesis Antibodies, Bacterial - immunology Bacterial Vaccines - administration & dosage Bacterial Vaccines - immunology Female Immunity, Maternally-Acquired - immunology Immunization Immunization Schedule Immunization, Passive Immunization, Secondary Immunoglobulin G - biosynthesis Immunoglobulin G - immunology Models, Biological Opsonin Proteins - immunology Pregnancy Pregnancy Complications, Infectious - immunology Pregnancy Complications, Infectious - prevention & control Rats Rats, Inbred Strains Streptococcal Infections - prevention & control Streptococcus agalactiae - immunology Vaccines, Inactivated - administration & dosage Vaccines, Inactivated - immunology |
| title | The Opsonic Antibody Response of Female Rats to Type III Group B Streptococcal Immunization: a Model for Maternal Immunity |
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