The Effect of Dietary Soy Supplementation on Hot Flushes
OBJECTIVETo assess the effect of daily dietary supplementation of soy protein isolate powder on hot flushes in post-menopausal women. METHODSWe carried out a double-blind, parallel, multi-center, randomized placebo-controlled trial of 104 post-menopausal women. Fifty-one patients (age range 48–61 ye...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 1998-01, Vol.91 (1), p.6-11 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
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| creator | ALBERTAZZI, PAOLA PANSINI, FRANCESCO BONACCORSI, GLORIA ZANOTTI, LAURA FORINI, ELENA ALOYSIO, DOMENICO DE |
| description | OBJECTIVETo assess the effect of daily dietary supplementation of soy protein isolate powder on hot flushes in post-menopausal women.
METHODSWe carried out a double-blind, parallel, multi-center, randomized placebo-controlled trial of 104 post-menopausal women. Fifty-one patients (age range 48–61 years) took 60 g of isolated soy protein daily and 53 patients (age range 45–62 years) took 60 g of placebo (casein) daily. The study lasted 12 weeks. Using analysis of covariance, we analyzed changes from baseline in mean number of moderate to severe hot flushes (including night sweats) during treatment.
RESULTSSoy was significantly superior to placebo (P < .01 in reducing the mean number of hot flushes per 24 hours after 4, 8, and 12 weeks of treatment. In particular, women taking soy had a 26% reduction in the mean number of hot flushes by week 3 and a 33% reduction by week 4 (P < .001 by the Wilcoxon exact test). By the end of the 12th week, patients taking soy had a 45% reduction in their daily hot flushes versus a 30% reduction obtained with the placebo (P < .01). The overall rates of adverse effects were similar for soy and casein-placebo. Twenty-five patients dropped out of the study11 in the soy group and 14 in the placebo group. Gastrointestinal side effects were the most common cause of premature withdrawal from the study (seven patients in each group).
CONCLUSIONSoy protein isolate added daily to the diet substantially reduced the frequency of hot flushes in climacteric women. |
| doi_str_mv | 10.1016/s0029-7844(97)00597-8 |
| format | Article |
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METHODSWe carried out a double-blind, parallel, multi-center, randomized placebo-controlled trial of 104 post-menopausal women. Fifty-one patients (age range 48–61 years) took 60 g of isolated soy protein daily and 53 patients (age range 45–62 years) took 60 g of placebo (casein) daily. The study lasted 12 weeks. Using analysis of covariance, we analyzed changes from baseline in mean number of moderate to severe hot flushes (including night sweats) during treatment.
RESULTSSoy was significantly superior to placebo (P < .01 in reducing the mean number of hot flushes per 24 hours after 4, 8, and 12 weeks of treatment. In particular, women taking soy had a 26% reduction in the mean number of hot flushes by week 3 and a 33% reduction by week 4 (P < .001 by the Wilcoxon exact test). By the end of the 12th week, patients taking soy had a 45% reduction in their daily hot flushes versus a 30% reduction obtained with the placebo (P < .01). The overall rates of adverse effects were similar for soy and casein-placebo. Twenty-five patients dropped out of the study11 in the soy group and 14 in the placebo group. Gastrointestinal side effects were the most common cause of premature withdrawal from the study (seven patients in each group).
CONCLUSIONSoy protein isolate added daily to the diet substantially reduced the frequency of hot flushes in climacteric women.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>DOI: 10.1016/s0029-7844(97)00597-8</identifier><identifier>PMID: 9464712</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>New York, NY: The American College of Obstetricians and Gynecologists</publisher><subject>Biological and medical sciences ; Cohort Studies ; Dietary Supplements - adverse effects ; Double-Blind Method ; Female ; Gynecology. Andrology. Obstetrics ; Hot Flashes - diet therapy ; Hot Flashes - metabolism ; Hot Flashes - physiopathology ; Humans ; Medical sciences ; Middle Aged ; Postmenopause - drug effects ; Postmenopause - physiology ; Puberal and climacteric disorders (male and female) ; Soybean Proteins - administration & dosage ; Soybean Proteins - adverse effects ; Soybean Proteins - therapeutic use ; Time Factors</subject><ispartof>Obstetrics and gynecology (New York. 1953), 1998-01, Vol.91 (1), p.6-11</ispartof><rights>1998 The American College of Obstetricians and Gynecologists</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4442-f3248f7fad9b52e126568d0b2c1fce260b6db01f9257c768de6b80bd11ebac373</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,4012,27910,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2097643$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9464712$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ALBERTAZZI, PAOLA</creatorcontrib><creatorcontrib>PANSINI, FRANCESCO</creatorcontrib><creatorcontrib>BONACCORSI, GLORIA</creatorcontrib><creatorcontrib>ZANOTTI, LAURA</creatorcontrib><creatorcontrib>FORINI, ELENA</creatorcontrib><creatorcontrib>ALOYSIO, DOMENICO DE</creatorcontrib><title>The Effect of Dietary Soy Supplementation on Hot Flushes</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>OBJECTIVETo assess the effect of daily dietary supplementation of soy protein isolate powder on hot flushes in post-menopausal women.
METHODSWe carried out a double-blind, parallel, multi-center, randomized placebo-controlled trial of 104 post-menopausal women. Fifty-one patients (age range 48–61 years) took 60 g of isolated soy protein daily and 53 patients (age range 45–62 years) took 60 g of placebo (casein) daily. The study lasted 12 weeks. Using analysis of covariance, we analyzed changes from baseline in mean number of moderate to severe hot flushes (including night sweats) during treatment.
RESULTSSoy was significantly superior to placebo (P < .01 in reducing the mean number of hot flushes per 24 hours after 4, 8, and 12 weeks of treatment. In particular, women taking soy had a 26% reduction in the mean number of hot flushes by week 3 and a 33% reduction by week 4 (P < .001 by the Wilcoxon exact test). By the end of the 12th week, patients taking soy had a 45% reduction in their daily hot flushes versus a 30% reduction obtained with the placebo (P < .01). The overall rates of adverse effects were similar for soy and casein-placebo. Twenty-five patients dropped out of the study11 in the soy group and 14 in the placebo group. Gastrointestinal side effects were the most common cause of premature withdrawal from the study (seven patients in each group).
CONCLUSIONSoy protein isolate added daily to the diet substantially reduced the frequency of hot flushes in climacteric women.</description><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Dietary Supplements - adverse effects</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hot Flashes - diet therapy</subject><subject>Hot Flashes - metabolism</subject><subject>Hot Flashes - physiopathology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Postmenopause - drug effects</subject><subject>Postmenopause - physiology</subject><subject>Puberal and climacteric disorders (male and female)</subject><subject>Soybean Proteins - administration & dosage</subject><subject>Soybean Proteins - adverse effects</subject><subject>Soybean Proteins - therapeutic use</subject><subject>Time Factors</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kFtLxDAQhYMoul5-gtAHEX2oTi7N5VHWKwg-qOBbSNMJW81u16ZF_Pdm3WVhwpCc78yQQ8gphSsKVF4nAGZKpYW4MOoSoDKq1DtkQrXiJeP8Y5dMtsgBOUzpEyAbDd8n-0ZIoSibEP02w-IuBPRD0YXitsXB9b_Fa5fPuFxGnONicEPbLYpcj91Q3McxzTAdk73gYsKTTT8i7_d3b9PH8vnl4Wl681x6IQQrA2dCBxVcY-qKIWWykrqBmnkaPDIJtWxqoMGwSnmVJZS1hrqhFGvnueJH5Hw9d9l33yOmwc7b5DFGt8BuTFYZqbkWMoPVGvR9l1KPwS77dp4_YynYVWL2dRWHXcVhjbL_iVmdfaebBWM9x2br2kSU9bON7pJ3MfRu4du0xRgYJQXPmFhjP10csE9fcfzB3s7QxWGWlwFIVkFJjdFA861cPTH-B2Y3gis</recordid><startdate>199801</startdate><enddate>199801</enddate><creator>ALBERTAZZI, PAOLA</creator><creator>PANSINI, FRANCESCO</creator><creator>BONACCORSI, GLORIA</creator><creator>ZANOTTI, LAURA</creator><creator>FORINI, ELENA</creator><creator>ALOYSIO, DOMENICO DE</creator><general>The American College of Obstetricians and Gynecologists</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199801</creationdate><title>The Effect of Dietary Soy Supplementation on Hot Flushes</title><author>ALBERTAZZI, PAOLA ; PANSINI, FRANCESCO ; BONACCORSI, GLORIA ; ZANOTTI, LAURA ; FORINI, ELENA ; ALOYSIO, DOMENICO DE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4442-f3248f7fad9b52e126568d0b2c1fce260b6db01f9257c768de6b80bd11ebac373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Dietary Supplements - adverse effects</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hot Flashes - diet therapy</topic><topic>Hot Flashes - metabolism</topic><topic>Hot Flashes - physiopathology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Postmenopause - drug effects</topic><topic>Postmenopause - physiology</topic><topic>Puberal and climacteric disorders (male and female)</topic><topic>Soybean Proteins - administration & dosage</topic><topic>Soybean Proteins - adverse effects</topic><topic>Soybean Proteins - therapeutic use</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ALBERTAZZI, PAOLA</creatorcontrib><creatorcontrib>PANSINI, FRANCESCO</creatorcontrib><creatorcontrib>BONACCORSI, GLORIA</creatorcontrib><creatorcontrib>ZANOTTI, LAURA</creatorcontrib><creatorcontrib>FORINI, ELENA</creatorcontrib><creatorcontrib>ALOYSIO, DOMENICO DE</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ALBERTAZZI, PAOLA</au><au>PANSINI, FRANCESCO</au><au>BONACCORSI, GLORIA</au><au>ZANOTTI, LAURA</au><au>FORINI, ELENA</au><au>ALOYSIO, DOMENICO DE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Dietary Soy Supplementation on Hot Flushes</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>1998-01</date><risdate>1998</risdate><volume>91</volume><issue>1</issue><spage>6</spage><epage>11</epage><pages>6-11</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>OBJECTIVETo assess the effect of daily dietary supplementation of soy protein isolate powder on hot flushes in post-menopausal women.
METHODSWe carried out a double-blind, parallel, multi-center, randomized placebo-controlled trial of 104 post-menopausal women. Fifty-one patients (age range 48–61 years) took 60 g of isolated soy protein daily and 53 patients (age range 45–62 years) took 60 g of placebo (casein) daily. The study lasted 12 weeks. Using analysis of covariance, we analyzed changes from baseline in mean number of moderate to severe hot flushes (including night sweats) during treatment.
RESULTSSoy was significantly superior to placebo (P < .01 in reducing the mean number of hot flushes per 24 hours after 4, 8, and 12 weeks of treatment. In particular, women taking soy had a 26% reduction in the mean number of hot flushes by week 3 and a 33% reduction by week 4 (P < .001 by the Wilcoxon exact test). By the end of the 12th week, patients taking soy had a 45% reduction in their daily hot flushes versus a 30% reduction obtained with the placebo (P < .01). The overall rates of adverse effects were similar for soy and casein-placebo. Twenty-five patients dropped out of the study11 in the soy group and 14 in the placebo group. Gastrointestinal side effects were the most common cause of premature withdrawal from the study (seven patients in each group).
CONCLUSIONSoy protein isolate added daily to the diet substantially reduced the frequency of hot flushes in climacteric women.</abstract><cop>New York, NY</cop><pub>The American College of Obstetricians and Gynecologists</pub><pmid>9464712</pmid><doi>10.1016/s0029-7844(97)00597-8</doi><tpages>6</tpages></addata></record> |
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| subjects | Biological and medical sciences Cohort Studies Dietary Supplements - adverse effects Double-Blind Method Female Gynecology. Andrology. Obstetrics Hot Flashes - diet therapy Hot Flashes - metabolism Hot Flashes - physiopathology Humans Medical sciences Middle Aged Postmenopause - drug effects Postmenopause - physiology Puberal and climacteric disorders (male and female) Soybean Proteins - administration & dosage Soybean Proteins - adverse effects Soybean Proteins - therapeutic use Time Factors |
| title | The Effect of Dietary Soy Supplementation on Hot Flushes |
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