Effects of caerulein and cholecystokinin-octapeptide on acetylcholine and choline contents in the brains of intact and vagotomized mice
The effects of caerulein (CLN; 0.5, 5, and 50 μg/kg, IP) and cholecystokinin-octapeptide (CCK-8; 5, 50, and 400 μg/kg, IP) on the acetylcholine and choline contents in the discrete brain regions were examined, 30, 60, and 120 min after injection into intact and vagotomized mice. In all of the discre...
Gespeichert in:
| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1990, Vol.35 (1), p.143-149 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 149 |
|---|---|
| container_issue | 1 |
| container_start_page | 143 |
| container_title | Pharmacology, biochemistry and behavior |
| container_volume | 35 |
| creator | Miyate, Hiroki |
| description | The effects of caerulein (CLN; 0.5, 5, and 50 μg/kg, IP) and cholecystokinin-octapeptide (CCK-8; 5, 50, and 400 μg/kg, IP) on the acetylcholine and choline contents in the discrete brain regions were examined, 30, 60, and 120 min after injection into intact and vagotomized mice. In all of the discrete brain regions of the intact mice, CLN and CCK-8 was found to have a complex effect on the acetylcholine and choline contents depending on the brain region, dosage and treatment time. On the other hand, the effect of CLN was abolished completely in the vagotomized mice. Thus, the present study indicates that peripherally administered CLN and CCK-8 have an effect on the central cholinergic system, mainly mediated via the vagus. |
| doi_str_mv | 10.1016/0091-3057(90)90219-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79683775</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0091305790902198</els_id><sourcerecordid>79683775</sourcerecordid><originalsourceid>FETCH-LOGICAL-c281t-67dc95576676beeda95dcf3a53c44c6fb8751aa720f8231960ac1f4a9c9a3f933</originalsourceid><addsrcrecordid>eNqFkcGOFCEQholxs46rb6BJH4zRQys0DTSXTcxm1U028aJnwlQXLtoNIzCbzL6Ary09M5mje4KkvvoL6iPkFaMfGGXyI6WatZwK9U7T95p2TLfDE7Jig-KtYEo9JasT8ow8z_kXpbTvpDon5x1ngotuRf5eO4dQchNdAxbTdkIfGhvGBu7ihLDLJf72wYc2QrEb3BQ_YhMrAlh20wL5gKeG5Q4xFAw1sgaVO2zWyfqwH-BDsVD28L39GUuc_QOOzewBX5AzZ6eML4_nBfnx-fr71df29tuXm6tPty10AyutVCNoIZSUSq4RR6vFCI5bwaHvQbr1oASzVnXUDfWPWlILzPVWg7bcac4vyNtD7ibFP1vMxcw-A06TDRi32SgtB66UeBRkQgx1mbSC_QGEFHNO6Mwm-dmmnWHULKLMYsEsFoymZi_KDLXt9TF_u55xPDUdzdT6m2PdZrCTSzaAzydMKs11t0y_PGBYl3bvMZkMHgPg6FP1asbo__-OfwRasUQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15584260</pqid></control><display><type>article</type><title>Effects of caerulein and cholecystokinin-octapeptide on acetylcholine and choline contents in the brains of intact and vagotomized mice</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Miyate, Hiroki</creator><creatorcontrib>Miyate, Hiroki</creatorcontrib><description>The effects of caerulein (CLN; 0.5, 5, and 50 μg/kg, IP) and cholecystokinin-octapeptide (CCK-8; 5, 50, and 400 μg/kg, IP) on the acetylcholine and choline contents in the discrete brain regions were examined, 30, 60, and 120 min after injection into intact and vagotomized mice. In all of the discrete brain regions of the intact mice, CLN and CCK-8 was found to have a complex effect on the acetylcholine and choline contents depending on the brain region, dosage and treatment time. On the other hand, the effect of CLN was abolished completely in the vagotomized mice. Thus, the present study indicates that peripherally administered CLN and CCK-8 have an effect on the central cholinergic system, mainly mediated via the vagus.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/0091-3057(90)90219-8</identifier><identifier>PMID: 2315352</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acetylcholine ; Acetylcholine - metabolism ; Animals ; Biological and medical sciences ; Brain Chemistry - drug effects ; Caerulein (CLN) ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Ceruletide - pharmacology ; Cholecystokinin-octapeptide ; Choline ; Choline - metabolism ; Corpus Striatum - drug effects ; Discrete brain ; Frontal Lobe - drug effects ; Fundamental and applied biological sciences. Psychology ; Hippocampus - drug effects ; Hypothalamus - drug effects ; Male ; Mice ; Mice, Inbred Strains ; Mouse ; Nucleus Accumbens - drug effects ; Sincalide - pharmacology ; Vagotomy ; Vertebrates: nervous system and sense organs</subject><ispartof>Pharmacology, biochemistry and behavior, 1990, Vol.35 (1), p.143-149</ispartof><rights>1990</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c281t-67dc95576676beeda95dcf3a53c44c6fb8751aa720f8231960ac1f4a9c9a3f933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0091-3057(90)90219-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6793920$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2315352$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyate, Hiroki</creatorcontrib><title>Effects of caerulein and cholecystokinin-octapeptide on acetylcholine and choline contents in the brains of intact and vagotomized mice</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>The effects of caerulein (CLN; 0.5, 5, and 50 μg/kg, IP) and cholecystokinin-octapeptide (CCK-8; 5, 50, and 400 μg/kg, IP) on the acetylcholine and choline contents in the discrete brain regions were examined, 30, 60, and 120 min after injection into intact and vagotomized mice. In all of the discrete brain regions of the intact mice, CLN and CCK-8 was found to have a complex effect on the acetylcholine and choline contents depending on the brain region, dosage and treatment time. On the other hand, the effect of CLN was abolished completely in the vagotomized mice. Thus, the present study indicates that peripherally administered CLN and CCK-8 have an effect on the central cholinergic system, mainly mediated via the vagus.</description><subject>Acetylcholine</subject><subject>Acetylcholine - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain Chemistry - drug effects</subject><subject>Caerulein (CLN)</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Ceruletide - pharmacology</subject><subject>Cholecystokinin-octapeptide</subject><subject>Choline</subject><subject>Choline - metabolism</subject><subject>Corpus Striatum - drug effects</subject><subject>Discrete brain</subject><subject>Frontal Lobe - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus - drug effects</subject><subject>Hypothalamus - drug effects</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Mouse</subject><subject>Nucleus Accumbens - drug effects</subject><subject>Sincalide - pharmacology</subject><subject>Vagotomy</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcGOFCEQholxs46rb6BJH4zRQys0DTSXTcxm1U028aJnwlQXLtoNIzCbzL6Ary09M5mje4KkvvoL6iPkFaMfGGXyI6WatZwK9U7T95p2TLfDE7Jig-KtYEo9JasT8ow8z_kXpbTvpDon5x1ngotuRf5eO4dQchNdAxbTdkIfGhvGBu7ihLDLJf72wYc2QrEb3BQ_YhMrAlh20wL5gKeG5Q4xFAw1sgaVO2zWyfqwH-BDsVD28L39GUuc_QOOzewBX5AzZ6eML4_nBfnx-fr71df29tuXm6tPty10AyutVCNoIZSUSq4RR6vFCI5bwaHvQbr1oASzVnXUDfWPWlILzPVWg7bcac4vyNtD7ibFP1vMxcw-A06TDRi32SgtB66UeBRkQgx1mbSC_QGEFHNO6Mwm-dmmnWHULKLMYsEsFoymZi_KDLXt9TF_u55xPDUdzdT6m2PdZrCTSzaAzydMKs11t0y_PGBYl3bvMZkMHgPg6FP1asbo__-OfwRasUQ</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Miyate, Hiroki</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>Effects of caerulein and cholecystokinin-octapeptide on acetylcholine and choline contents in the brains of intact and vagotomized mice</title><author>Miyate, Hiroki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-67dc95576676beeda95dcf3a53c44c6fb8751aa720f8231960ac1f4a9c9a3f933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Acetylcholine</topic><topic>Acetylcholine - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain Chemistry - drug effects</topic><topic>Caerulein (CLN)</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Ceruletide - pharmacology</topic><topic>Cholecystokinin-octapeptide</topic><topic>Choline</topic><topic>Choline - metabolism</topic><topic>Corpus Striatum - drug effects</topic><topic>Discrete brain</topic><topic>Frontal Lobe - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus - drug effects</topic><topic>Hypothalamus - drug effects</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Mouse</topic><topic>Nucleus Accumbens - drug effects</topic><topic>Sincalide - pharmacology</topic><topic>Vagotomy</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyate, Hiroki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyate, Hiroki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of caerulein and cholecystokinin-octapeptide on acetylcholine and choline contents in the brains of intact and vagotomized mice</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1990</date><risdate>1990</risdate><volume>35</volume><issue>1</issue><spage>143</spage><epage>149</epage><pages>143-149</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>The effects of caerulein (CLN; 0.5, 5, and 50 μg/kg, IP) and cholecystokinin-octapeptide (CCK-8; 5, 50, and 400 μg/kg, IP) on the acetylcholine and choline contents in the discrete brain regions were examined, 30, 60, and 120 min after injection into intact and vagotomized mice. In all of the discrete brain regions of the intact mice, CLN and CCK-8 was found to have a complex effect on the acetylcholine and choline contents depending on the brain region, dosage and treatment time. On the other hand, the effect of CLN was abolished completely in the vagotomized mice. Thus, the present study indicates that peripherally administered CLN and CCK-8 have an effect on the central cholinergic system, mainly mediated via the vagus.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2315352</pmid><doi>10.1016/0091-3057(90)90219-8</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-3057 |
| ispartof | Pharmacology, biochemistry and behavior, 1990, Vol.35 (1), p.143-149 |
| issn | 0091-3057 1873-5177 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79683775 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Acetylcholine Acetylcholine - metabolism Animals Biological and medical sciences Brain Chemistry - drug effects Caerulein (CLN) Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Ceruletide - pharmacology Cholecystokinin-octapeptide Choline Choline - metabolism Corpus Striatum - drug effects Discrete brain Frontal Lobe - drug effects Fundamental and applied biological sciences. Psychology Hippocampus - drug effects Hypothalamus - drug effects Male Mice Mice, Inbred Strains Mouse Nucleus Accumbens - drug effects Sincalide - pharmacology Vagotomy Vertebrates: nervous system and sense organs |
| title | Effects of caerulein and cholecystokinin-octapeptide on acetylcholine and choline contents in the brains of intact and vagotomized mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T13%3A57%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20caerulein%20and%20cholecystokinin-octapeptide%20on%20acetylcholine%20and%20choline%20contents%20in%20the%20brains%20of%20intact%20and%20vagotomized%20mice&rft.jtitle=Pharmacology,%20biochemistry%20and%20behavior&rft.au=Miyate,%20Hiroki&rft.date=1990&rft.volume=35&rft.issue=1&rft.spage=143&rft.epage=149&rft.pages=143-149&rft.issn=0091-3057&rft.eissn=1873-5177&rft.coden=PBBHAU&rft_id=info:doi/10.1016/0091-3057(90)90219-8&rft_dat=%3Cproquest_cross%3E79683775%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15584260&rft_id=info:pmid/2315352&rft_els_id=0091305790902198&rfr_iscdi=true |