Differential effects of Staphylococcus aureus alpha-hemolysin on the synthesis of hyaluronan and chondroitin sulfate by rat chondrosarcoma chondrocytes

The plasma membranes of rat chondrosarcoma chondrocytes were permeabilized by treatment with alpha-hemolysin, the major toxin produced by Staphylococcus aureus, which forms small, stable, heptameric, transmembrane pores (1-2 nm in diameter) permitting influx/efflux of low-molecular-mass molecules (&...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1998-02, Vol.350 (1), p.26-35
Hauptverfasser:	Goodstone, N J, Hascall, V C, Calabro, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - deficiency Animals Bacterial Toxins - pharmacology Cartilage - cytology Cartilage - drug effects Cell Membrane Permeability Chondrocytes - cytology Chondrocytes - drug effects Chondroitin Sulfates - biosynthesis Chondrosarcoma Culture Media, Serum-Free Glucosamine - metabolism Hemolysin Proteins - pharmacology Hyaluronic Acid - biosynthesis Molecular Weight Rats Tumor Cells, Cultured
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